# PERCEPTIVE ADVISORS LLC: Form 13F holdings

An institutional investment manager in NEW YORK, NY. SEC CIK 1224962.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $6.66bn
- Positions: 109 (109 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1224962/000101297526000777/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [PRAXIS PRECISION MEDICINES I (PRAX)](/companies/prax.md) | COM NEW | $681.6m | 10.2% | 2,035,986 |  | Unchanged |
| [SPYRE THERAPEUTICS INC (SYRE)](/companies/syre.md) | COM NEW | $383.5m | 5.8% | 4,319,496 |  | Added +536,271 |
| [CELCUITY INC (CELC)](/companies/celc.md) | COM | $334.5m | 5.0% | 3,197,200 |  | Added +70,000 |
| ASCENDIS PHARMA A/S | ORD SHS | $310.4m | 4.7% | 1,163,721 |  | New +1,163,721 |
| [RHYTHM PHARMACEUTICALS INC (RYTM)](/companies/rytm.md) | COM | $287.2m | 4.3% | 2,586,295 |  | Added +212,500 |
| ROIVANT SCIENCES LTD | SHS | $286.1m | 4.3% | 8,085,461 |  | Reduced −200,000 |
| [RELAY THERAPEUTICS INC (RLAY)](/companies/rlay.md) | COM | $263.9m | 4.0% | 14,106,187 |  | Added +4,355,046 |
| [TRAVERE THERAPEUTICS INC (TVTX)](/companies/tvtx.md) | COM | $213.2m | 3.2% | 3,752,574 |  | Reduced −389,977 |
| [KARDIGAN INC (KARD)](/companies/kard.md) | COM | $195.6m | 2.9% | 8,200,662 |  | New +8,200,662 |
| NUVALENT INC | COM | $195.2m | 2.9% | 1,580,505 |  | Unchanged |
| [EDGEWISE THERAPEUTICS INC (EWTX)](/companies/ewtx.md) | COM | $177.7m | 2.7% | 4,373,974 |  | Reduced −50,000 |
| APOGEE THERAPEUTICS INC | COM | $173.6m | 2.6% | 1,308,113 |  | Reduced −232,271 |
| [AMYLYX PHARMACEUTICALS INC (AMLX)](/companies/amlx.md) | COM | $149.7m | 2.2% | 8,334,882 |  | Added +50,000 |
| MEIRAGTX HLDGS PLC | COM | $145.7m | 2.2% | 10,786,658 |  | Added +460,555 |
| [ORUKA THERAPEUTICS INC (ORKA)](/companies/orka.md) | COM | $128.0m | 1.9% | 1,345,063 |  | Reduced −50,438 |
| [INHIBRX BIOSCIENCES INC (INBX)](/companies/inbx.md) | COM | $123.0m | 1.8% | 1,297,763 |  | Reduced −144,944 |
| [PROTAGONIST THERAPEUTICS INC (PTGX)](/companies/ptgx.md) | COM | $120.4m | 1.8% | 981,879 |  | Reduced −249,000 |
| [SOLID BIOSCIENCES INC (SLDB)](/companies/sldb.md) | COM NEW | $118.9m | 1.8% | 11,906,646 |  | Unchanged |
| [ZYMEWORKS INC (ZYME)](/companies/zyme.md) | COM | $109.3m | 1.6% | 4,182,953 |  | Added +672,875 |
| [TANGO THERAPEUTICS INC (TNGX)](/companies/tngx.md) | COM | $105.6m | 1.6% | 3,377,000 |  | Added +2,568,847 |
| IMMATICS N.V | SHS | $105.2m | 1.6% | 10,383,456 |  | Unchanged |
| [NURIX THERAPEUTICS INC (NRIX)](/companies/nrix.md) | COM | $104.8m | 1.6% | 4,320,422 |  | Added +609,545 |
| [BIOCRYST PHARMACEUTICALS INC (BCRX)](/companies/bcrx.md) | COM | $103.1m | 1.5% | 10,308,888 |  | Added +2,874,855 |
| [REVOLUTION MEDICINES INC (RVMD)](/companies/rvmd.md) | COM | $98.8m | 1.5% | 527,600 |  | Added +269,000 |
| [AVALYN PHARMACEUTICALS INC (AVLN)](/companies/avln.md) | COM SHS | $88.1m | 1.3% | 2,675,296 |  | New +2,675,296 |
| [MODERNA INC (MRNA)](/companies/mrna.md) | COM | $70.0m | 1.1% | 1,000,000 | Put | Unchanged |
| [DYNE THERAPEUTICS INC (DYN)](/companies/dyn.md) | COM | $59.7m | 0.9% | 2,689,235 |  | Reduced −1,979,604 |
| [BIOGEN INC (BIIB)](/companies/biib.md) | COM | $59.7m | 0.9% | 276,173 |  | New +276,173 |
| [IMMUNOVANT INC (IMVT)](/companies/imvt.md) | COM | $52.3m | 0.8% | 1,357,383 |  | Reduced −240,000 |
| [UNITEDHEALTH GROUP INC (UNH)](/companies/unh.md) | COM | $48.5m | 0.7% | 116,806 |  | New +116,806 |
| SPDR SERIES TRUST | ST STR SP BIOT | $47.5m | 0.7% | 300,000 | Put | New +300,000 |
| [IONIS PHARMACEUTICALS INC (IONS)](/companies/ions.md) | COM | $44.9m | 0.7% | 566,000 |  | Added +62,000 |
| [SUTRO BIOPHARMA INC (STRO)](/companies/stro.md) | COM SHS | $43.3m | 0.7% | 1,304,846 |  | Added +589,539 |
| [ALTO NEUROSCIENCE INC (ANRO)](/companies/anro.md) | COM SHS | $42.5m | 0.6% | 1,609,893 |  | Reduced −400,000 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | $41.0m | 0.6% | 170,000 |  | Unchanged |
| [CORVUS PHARMACEUTICALS INC (CRVS)](/companies/crvs.md) | COM | $39.9m | 0.6% | 2,667,441 |  | Added +375,000 |
| [SIONNA THERAPEUTICS INC (SION)](/companies/sion.md) | COM | $39.8m | 0.6% | 905,000 |  | Added +246,561 |
| [CYTOMX THERAPEUTICS INC. (CTMX)](/companies/ctmx.md) | COM | $39.1m | 0.6% | 10,439,185 |  | Added +340,361 |
| [ARTIVION INC (AORT)](/companies/aort.md) | COM | $39.0m | 0.6% | 1,737,290 |  | Added +100,000 |
| [X4 PHARMACEUTICALS INC (XFOR)](/companies/xfor.md) | COM NEW | $37.0m | 0.6% | 7,933,491 |  | Added +1,195,843 |
| [CORCEPT THERAPEUTICS INC (CORT)](/companies/cort.md) | COM | $34.6m | 0.5% | 398,385 |  | Added +348,385 |
| [REPLIGEN CORP (RGEN)](/companies/rgen.md) | COM | $33.9m | 0.5% | 248,212 |  | Reduced −32,329 |
| [ANTERIS TECHNOLOGIES GLOBAL (AVR)](/companies/avr.md) | COM | $33.7m | 0.5% | 3,425,476 |  | Unchanged |
| [RAPPORT THERAPEUTICS INC (RAPP)](/companies/rapp.md) | COM | $32.2m | 0.5% | 773,342 |  | Added +99,419 |
| DAMORA THERAPEUTICS INC | COM NEW | $31.8m | 0.5% | 1,223,000 |  | Unchanged |
| [CHARLES RIV LABS INTL INC (CRL)](/companies/crl.md) | COM | $31.8m | 0.5% | 140,000 |  | New +140,000 |
| [AXSOME THERAPEUTICS INC. (AXSM)](/companies/axsm.md) | COM | $29.0m | 0.4% | 118,450 |  | Reduced −31,500 |
| [EYEPOINT INC (EYPT)](/companies/eypt.md) | COM NEW | $28.6m | 0.4% | 2,000,000 | Put | New +2,000,000 |
| [DBV TECHNOLOGIES S A (DBVT)](/companies/dbvt.md) | SPONSORED ADS | $27.1m | 0.4% | 1,653,350 |  | Added +688,959 |
| [IRHYTHM HOLDINGS INC (IRTC)](/companies/irtc.md) | COM | $26.6m | 0.4% | 223,766 |  | Added +118,740 |
| [ADAPTIVE BIOTECHNOLOGIES COR (ADPT)](/companies/adpt.md) | COM | $26.1m | 0.4% | 1,217,325 |  | Added +1,064,825 |
| [SAB BIOTHERAPEUTICS INC (SABS)](/companies/sabs.md) | COM NEW | $25.8m | 0.4% | 6,627,501 |  | Added +195,758 |
| [DANAHER CORP DEL (DHR)](/companies/dhr.md) | COM | $24.8m | 0.4% | 130,000 |  | New +130,000 |
| [TENAX THERAPEUTICS INC (TENX)](/companies/tenx.md) | COM NEW | $24.7m | 0.4% | 1,700,000 |  | Added +252,218 |
| [CAPRICOR THERAPEUTICS INC (CAPR)](/companies/capr.md) | COM NEW | $24.1m | 0.4% | 1,000,000 | Call | New +1,000,000 |
| [SELLAS LIFE SCIENCES GROUP I (SLS)](/companies/sls.md) | COM NEW | $22.1m | 0.3% | 1,500,000 | Put | New +1,500,000 |
| [NAUTILUS BIOTECHNOLOGY INC (NAUT)](/companies/naut.md) | COM | $21.8m | 0.3% | 11,634,211 |  | Reduced −960,000 |
| [ORCHESTRA BIOMED HLDGS INC (OBIO)](/companies/obio.md) | COM | $21.7m | 0.3% | 5,037,906 |  | Unchanged |
| [INTUITIVE SURGICAL INC (ISRG)](/companies/isrg.md) | COM NEW | $20.6m | 0.3% | 51,884 |  | Reduced −33,535 |
| [ADLAI NORTYE LTD (ANL)](/companies/anl.md) | SPONSORED ADS | $20.6m | 0.3% | 1,793,190 |  | New +1,793,190 |
| [CONTINEUM THERAPEUTICS INC (CTNM)](/companies/ctnm.md) | CL A | $20.6m | 0.3% | 1,255,592 |  | Unchanged |
| [NUVECTIS PHARMA INC (NVCT)](/companies/nvct.md) | COM | $18.4m | 0.3% | 1,000,000 |  | New +1,000,000 |
| [PALISADE BIO INC (PALI)](/companies/pali.md) | COM | $17.6m | 0.3% | 8,425,065 |  | Reduced −503,084 |
| [OMADA HEALTH INC (OMDA)](/companies/omda.md) | COM | $17.3m | 0.3% | 786,330 |  | Unchanged |
| [LEONABIO INC (LONA)](/companies/lona.md) | COM | $17.1m | 0.3% | 1,859,322 |  | Unchanged |
| [EVOLUS INC (EOLS)](/companies/eols.md) | COM | $17.1m | 0.3% | 2,459,285 |  | Added +1,172,423 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | $16.9m | 0.3% | 500,000 | Put | New +500,000 |
| [INVIVYD INC (IVVD)](/companies/ivvd.md) | COM | $16.1m | 0.2% | 18,490,636 |  | Reduced −2,368,667 |
| CELCUITY INC | NOTE  2.750% 8/0 | $14.6m | 0.2% | $6,500,000 principal |  | Unchanged |
| [MIRUM PHARMACEUTICALS INC (MIRM)](/companies/mirm.md) | COM | $13.5m | 0.2% | 115,391 |  | New +115,391 |
| [SURROZEN INC (SRZN)](/companies/srzn.md) | COM NEW | $13.1m | 0.2% | 503,985 |  | Added +274,592 |
| [BETA BIONICS INC (BBNX)](/companies/bbnx.md) | COM | $13.1m | 0.2% | 832,944 |  | Reduced −10,000 |
| [CAPRICOR THERAPEUTICS INC (CAPR)](/companies/capr.md) | COM NEW | $12.0m | 0.2% | 500,000 | Put | New +500,000 |
| [AXOGEN INC (AXGN)](/companies/axgn.md) | COM | $11.4m | 0.2% | 247,312 |  | Reduced −450,000 |
| [OSCAR HEALTH INC (OSCR)](/companies/oscr.md) | CL A | $11.4m | 0.2% | 400,000 |  | New +400,000 |
| OCULIS HOLDING AG | ORDINARY SHARES | $11.2m | 0.2% | 808,827 |  | Added +315,000 |
| [SEAPORT THERAPEUTICS INC (SPTX)](/companies/sptx.md) | COMMON STOCK | $10.9m | 0.2% | 500,000 |  | New +500,000 |
| [VIRIDIAN THERAPEUTICS INC (VRDN)](/companies/vrdn.md) | COM | $10.7m | 0.2% | 581,980 |  | Reduced −588,849 |
| [BOSTON SCIENTIFIC CORP (BSX)](/companies/bsx.md) | COM | $10.7m | 0.2% | 250,000 |  | New +250,000 |
| [BILLIONTOONE INC (BLLN)](/companies/blln.md) | CL A | $10.4m | 0.2% | 86,812 |  | Reduced −5,000 |
| [ABIVAX SA (ABVX)](/companies/abvx.md) | SPONSORED ADS | $9.9m | 0.1% | 74,000 |  | Reduced −254,884 |
| [NATERA INC (NTRA)](/companies/ntra.md) | COM | $9.4m | 0.1% | 34,689 |  | New +34,689 |
| [ENGENE THERAPEUTICS INC (ENGN)](/companies/engn.md) | COM | $8.3m | 0.1% | 4,822,169 |  | New +4,822,169 |
| RESEARCH ALLIANCE CORP III | ORD SHS CL A | $8.0m | 0.1% | 750,000 |  | New +750,000 |
| [AGOMAB THERAPEUTICS NV (AGMB)](/companies/agmb.md) | SPONSORED ADS | $7.8m | 0.1% | 600,000 |  | Unchanged |
| [CULLINAN THERAPEUTICS INC (CGEM)](/companies/cgem.md) | COM | $7.8m | 0.1% | 426,478 |  | New +426,478 |
| UNIQURE NV | SHS | $7.7m | 0.1% | 168,000 |  | New +168,000 |
| [MOBIA MED INC (MOBI)](/companies/mobi.md) | COMMON STOCK | $7.0m | 0.1% | 523,654 |  | New +523,654 |
| [ADAGIO MED HLDGS INC (ADGM)](/companies/adgm.md) | COM | $6.4m | <0.1% | 9,876,586 |  | Added +10 |
| [GUARDANT HEALTH INC (GH)](/companies/gh.md) | COM | $6.2m | <0.1% | 41,327 |  | Reduced −258,673 |
| [PHATHOM PHARMACEUTICALS INC (PHAT)](/companies/phat.md) | COM | $5.8m | <0.1% | 532,000 |  | Reduced −393,000 |
| [OUTLOOK THERAPEUTICS INC (OTLK)](/companies/otlk.md) | COM | $5.0m | <0.1% | 3,139,216 |  | New +3,139,216 |
| [COGENT BIOSCIENCES INC (COGT)](/companies/cogt.md) | COM | $4.7m | <0.1% | 121,082 |  | Unchanged |
| [EDESA BIOTECH INC (EDSA)](/companies/edsa.md) | COM NEW | $4.6m | <0.1% | 563,239 |  | Unchanged |
| [AVALO THERAPEUTICS INC (AVTX)](/companies/avtx.md) | COM NEW | $4.1m | <0.1% | 219,813 |  | Added +80,146 |
| [TWIST BIOSCIENCE CORP (TWST)](/companies/twst.md) | COM | $3.8m | <0.1% | 36,812 |  | Reduced −113,188 |
| CRESCENT BIOPHARMA INC. | COM | $3.7m | <0.1% | 206,942 |  | Unchanged |
| [XERIS BIOPHARMA HOLDINGS INC (XERS)](/companies/xers.md) | COM | $3.7m | <0.1% | 467,013 |  | New +467,013 |
| [OUTSET MED INC (OM)](/companies/om.md) | COM NEW | $3.6m | <0.1% | 833,333 |  | Unchanged |
| [BIODESIX INC (BDSX)](/companies/bdsx.md) | COM | $2.5m | <0.1% | 108,694 |  | New +108,694 |
| [REVOLUTION MEDICINES INC (RVMD)](/companies/rvmd.md) | \*W EXP 12/17/202 | $2.3m | <0.1% | 250,000 |  | Unchanged |
| CONNECT BIOPHARMA HLDGS LTD | SHS | $1.9m | <0.1% | 792,696 |  | Unchanged |
| [KIORA PHARMACEUTICALS INC (KPRX)](/companies/kprx.md) | COM | $1.2m | <0.1% | 438,471 |  | New +438,471 |
| [MEDLINE INC (MDLN)](/companies/mdln.md) | COM CL A | $1.1m | <0.1% | 28,000 |  | Unchanged |
| [ADMA BIOLOGICS INC (ADMA)](/companies/adma.md) | COM | $952.2k | <0.1% | 113,765 |  | Reduced −353,468 |
| [CUMBERLAND PHARMACEUTICALS I (CPIX)](/companies/cpix.md) | COM | $628.4k | <0.1% | 96,982 |  | Reduced −99,996 |
| [EXAGEN INC (XGN)](/companies/xgn.md) | COM | $534.3k | <0.1% | 114,893 |  | Unchanged |
| [ENSYSCE BIOSCIENCES INC (ENSC)](/companies/ensc.md) | COM NEW | $25.1k | <0.1% | 86,666 |  | Unchanged |
| SURROZEN INC | \*W EXP 08/01/203 | $2.8k | <0.1% | 166,666 |  | Unchanged |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| APELLIS PHARMACEUTICALS INC | COM | $0 | 0.0% | 0 |  | Sold out −80,956 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | $0 | 0.0% | 0 |  | Sold out −1,531,421 |
| [BELITE BIO INC (BLTE)](/companies/blte.md) | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −151,979 |
| [BRIGHT MINDS BIOSCIENCES INC (DRUG)](/companies/drug.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −377,544 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −5,258,903 |
| DAY ONE BIOPHARMACEUTICALS I | COM | $0 | 0.0% | 0 |  | Sold out −1,755,799 |
| ENGENE HOLDINGS INC | COM | $0 | 0.0% | 0 |  | Sold out −5,827,506 |
| [EVOMMUNE INC (EVMN)](/companies/evmn.md) | COM SHS | $0 | 0.0% | 0 |  | Sold out −448,350 |
| [INHIBIKASE THERAPEUTICS INC (IKT)](/companies/ikt.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −2,315,000 |
| [NEUMORA THERAPEUTICS INC. (NMRA)](/companies/nmra.md) | COM | $0 | 0.0% | 0 |  | Sold out −5,104,097 |
| [NEUROCRINE BIOSCIENCES INC (NBIX)](/companies/nbix.md) | COM | $0 | 0.0% | 0 |  | Sold out −65,050 |
| [OCULAR THERAPEUTIX INC (OCUL)](/companies/ocul.md) | COM | $0 | 0.0% | 0 | Call | Sold out −500,000 |
| [OPUS GENETICS INC (IRD)](/companies/ird.md) | COM | $0 | 0.0% | 0 |  | Sold out −1,835,842 |
| [PALATIN TECHNOLOGIES INC (PTN)](/companies/ptn.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −61,945 |

Source: SEC EDGAR, Form 13F-HR, accession 0001012975-26-000777. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.