# GREAT POINT PARTNERS LLC: Form 13F holdings

An institutional investment manager in Greenwich, CT. SEC CIK 1281446.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $529.1m
- Positions: 42 (42 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1281446/000117266126003750/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [ABIVAX SA (ABVX)](/companies/abvx.md) | SPONSORED ADS | $53.3m | 10.1% | 400,000 | Call | New +400,000 |
| [VOR BIOPHARMA INC (VOR)](/companies/vor.md) | COM NEW | $31.3m | 5.9% | 1,700,000 |  | Reduced −50,000 |
| [ABIVAX SA (ABVX)](/companies/abvx.md) | SPONSORED ADS | $27.2m | 5.1% | 204,314 |  | New +204,314 |
| [IMMUNITYBIO INC (IBRX)](/companies/ibrx.md) | COM | $26.3m | 5.0% | 3,000,800 | Put | Unchanged |
| [VERA THERAPEUTICS INC (VERA)](/companies/vera.md) | CL A | $25.8m | 4.9% | 600,836 |  | Added +401,488 |
| ZURA BIO LTD | CLASS A ORD SHS | $24.9m | 4.7% | 4,215,930 |  | Unchanged |
| [ALUMIS INC (ALMS)](/companies/alms.md) | COM | $24.1m | 4.6% | 856,061 |  | Unchanged |
| SOL-GEL TECHNOLOGIES LTD | SHS NEW | $20.3m | 3.8% | 274,363 |  | Unchanged |
| [ULTRAGENYX PHARMACEUTICAL IN (RARE)](/companies/rare.md) | COM | $20.0m | 3.8% | 600,000 | Put | New +600,000 |
| [DEFINIUM THERAPEUTICS INC (DFTX)](/companies/dftx.md) | COM SHS | $20.0m | 3.8% | 425,000 |  | New +425,000 |
| [ANNEXON INC (ANNX)](/companies/annx.md) | COM | $20.0m | 3.8% | 3,500,000 |  | Added +1,000,000 |
| [ORUKA THERAPEUTICS INC (ORKA)](/companies/orka.md) | COM | $17.4m | 3.3% | 183,330 |  | Unchanged |
| [MOONLAKE IMMUNOTHERAPEUTICS (MLTX)](/companies/mltx.md) | CLASS A ORD | $16.7m | 3.1% | 855,813 |  | Added +355,813 |
| [SAGIMET BIOSCIENCES INC (SGMT)](/companies/sgmt.md) | COM SER A | $15.7m | 3.0% | 2,029,933 |  | New +2,029,933 |
| [CONTINEUM THERAPEUTICS INC (CTNM)](/companies/ctnm.md) | CL A | $15.1m | 2.9% | 921,481 |  | Added +121,283 |
| [IMMIX BIOPHARMA INC (IMMX)](/companies/immx.md) | COM | $13.2m | 2.5% | 1,277,642 |  | Added +927,642 |
| [CLIMB BIO INC (CLYM)](/companies/clym.md) | COM | $13.0m | 2.5% | 1,000,000 |  | Reduced −334,130 |
| [AMYLYX PHARMACEUTICALS INC (AMLX)](/companies/amlx.md) | COM | $12.6m | 2.4% | 700,000 |  | Reduced −1,050,000 |
| [NEKTAR THERAPEUTICS (NKTR)](/companies/nktr.md) | COM NEW | $12.2m | 2.3% | 175,000 |  | Reduced −141,453 |
| [NEUROGENE INC (NGNE)](/companies/ngne.md) | COM | $11.1m | 2.1% | 352,180 |  | Reduced −147,820 |
| [LB PHARMACEUTICALS INC (LBRX)](/companies/lbrx.md) | COM SHS | $10.3m | 1.9% | 317,221 |  | Added +17,221 |
| [OPUS GENETICS INC (IRD)](/companies/ird.md) | COM | $8.1m | 1.5% | 1,970,187 |  | Added +1,645,847 |
| [EUPRAXIA PHARMACEUTICALS INC (EPRX)](/companies/eprx.md) | COM | $7.9m | 1.5% | 1,200,000 |  | Unchanged |
| [BRIGHT MINDS BIOSCIENCES INC (DRUG)](/companies/drug.md) | COM NEW | $7.7m | 1.5% | 109,603 |  | Reduced −110,397 |
| INFLARX NV | COM | $6.8m | 1.3% | 3,046,557 |  | New +3,046,557 |
| [RELMADA THERAPEUTICS INC (RLMD)](/companies/rlmd.md) | COM | $5.8m | 1.1% | 842,106 |  | Unchanged |
| JATT II ACQUISITION CORP | ORD SHS | $5.7m | 1.1% | 500,000 |  | New +500,000 |
| [CULLINAN THERAPEUTICS INC (CGEM)](/companies/cgem.md) | COM | $5.5m | 1.0% | 300,000 |  | Unchanged |
| [ALTIMMUNE INC (ALT)](/companies/alt.md) | COM NEW | $5.3m | 1.0% | 1,741,232 |  | New +1,741,232 |
| AMANAT ACQUISITION CORP | CL A ORD | $5.1m | 1.0% | 500,000 |  | New +500,000 |
| [REZOLUTE INC (RZLT)](/companies/rzlt.md) | COM NEW | $4.9m | 0.9% | 951,809 |  | Unchanged |
| [SILENCE THERAPEUTICS PLC (SLN)](/companies/sln.md) | ADS | $4.9m | 0.9% | 450,000 |  | Reduced −570,489 |
| [PALISADE BIO INC (PALI)](/companies/pali.md) | COM | $4.8m | 0.9% | 2,284,819 |  | Reduced −1,120,938 |
| [EVOMMUNE INC (EVMN)](/companies/evmn.md) | COM SHS | $4.3m | 0.8% | 325,000 |  | Unchanged |
| [SCYNEXIS INC (SCYX)](/companies/scyx.md) | COM | $3.8m | 0.7% | 944,292 |  | New +944,292 |
| [GALECTIN THERAPEUTICS INC (GALT)](/companies/galt.md) | COM NEW | $3.7m | 0.7% | 800,000 | Call | Unchanged |
| [ENLIVEN THERAPEUTICS INC (ELVN)](/companies/elvn.md) | COM | $3.6m | 0.7% | 70,000 |  | New +70,000 |
| [HUMACYTE INC (HUMA)](/companies/huma.md) | COM | $2.9m | 0.6% | 3,750,000 |  | Unchanged |
| [REIN THERAPEUTICS INC (RNTX)](/companies/rntx.md) | COM NEW | $2.7m | 0.5% | 2,575,000 |  | New +2,575,000 |
| [DBV TECHNOLOGIES S A (DBVT)](/companies/dbvt.md) | SPONSORED ADS | $2.6m | 0.5% | 156,906 |  | New +156,906 |
| [ANAVEX LIFE SCIENCES CORP (AVXL)](/companies/avxl.md) | COM NEW | $1.4m | 0.3% | 521,300 | Call | Unchanged |
| [PROMIS NEUROSCIENCES INC (PMN)](/companies/pmn.md) | COM SHS | $1.1m | 0.2% | 86,150 |  | Reduced −285,252 |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| ALKERMES PLC | SHS | $0 | 0.0% | 0 |  | Sold out −50,000 |
| APOGEE THERAPEUTICS INC | COM | $0 | 0.0% | 0 |  | Sold out −374,000 |
| [AVALO THERAPEUTICS INC (AVTX)](/companies/avtx.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −124,666 |
| [COMPASS THERAPEUTICS INC (CMPX)](/companies/cmpx.md) | COM | $0 | 0.0% | 0 |  | Sold out −1,350,000 |
| [CONTEXT THERAPEUTICS INC (CNTX)](/companies/cntx.md) | COM | $0 | 0.0% | 0 |  | Sold out −2,238,496 |
| [IMMUNOVANT INC (IMVT)](/companies/imvt.md) | COM | $0 | 0.0% | 0 |  | Sold out −545,625 |
| [JADE BIOSCIENCES INC (JBIO)](/companies/jbio.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −964,462 |
| KALVISTA PHARMACEUTICALS INC | COM | $0 | 0.0% | 0 |  | Sold out −675,000 |
| PHARVARIS N V | COM | $0 | 0.0% | 0 |  | Sold out −82,800 |
| SCYNEXIS INC | COM NEW | $0 | 0.0% | 0 |  | Sold out −7,554,347 |
| [TENAX THERAPEUTICS INC (TENX)](/companies/tenx.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −327,307 |
| [UNICYCIVE THERAPEUTICS INC (UNCY)](/companies/uncy.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −796,558 |
| [ZENAS BIOPHARMA INC (ZBIO)](/companies/zbio.md) | COM | $0 | 0.0% | 0 |  | Sold out −524,066 |

Source: SEC EDGAR, Form 13F-HR, accession 0001172661-26-003750. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.