# RA CAPITAL MANAGEMENT, L.P.: Form 13F holdings

An institutional investment manager in BOSTON, MA. SEC CIK 1346824.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $11.51bn
- Positions: 84 (85 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1346824/000110465926097251/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| ASCENDIS PHARMA A/S | Common Stock | $2.74bn | 23.8% | 10,281,496 |  | New +10,281,496 |
| [PARABILIS MEDICINES INC (PBLS)](/companies/pbls.md) | Common Stock | $791.9m | 6.9% | 28,933,371 |  | New +28,933,371 |
| [RHYTHM PHARMACEUTICALS INC (RYTM)](/companies/rytm.md) | Common Stock | $740.2m | 6.4% | 6,666,837 |  | Unchanged |
| [VAXCYTE INC (PCVX)](/companies/pcvx.md) | Common Stock | $667.0m | 5.8% | 11,474,599 |  | Unchanged |
| [SIONNA THERAPEUTICS INC (SION)](/companies/sion.md) | Common Stock | $435.7m | 3.8% | 9,905,045 |  | Unchanged |
| [TYRA BIOSCIENCES INC (TYRA)](/companies/tyra.md) | Common Stock | $389.6m | 3.4% | 12,198,625 |  | Unchanged |
| [EDGEWISE THERAPEUTICS INC (EWTX)](/companies/ewtx.md) | Common Stock | $341.0m | 3.0% | 8,392,730 |  | Reduced −2,035,707 |
| NEWAMSTERDAM PHARMA CO NV | Common Stock | $323.7m | 2.8% | 9,550,191 |  | Unchanged |
| [HEMAB THERAPEUTICS HOLDINGS (COAG)](/companies/coag.md) | Common Stock | $286.8m | 2.5% | 7,808,627 |  | New +7,808,627 |
| [SEPTERNA INC (SEPN)](/companies/sepn.md) | Common Stock | $234.3m | 2.0% | 6,995,858 |  | Unchanged |
| [BICARA THERAPEUTICS INC (BCAX)](/companies/bcax.md) | Common Stock | $215.4m | 1.9% | 7,255,993 |  | Unchanged |
| [MINERALYS THERAPEUTICS INC (MLYS)](/companies/mlys.md) | Common Stock | $207.6m | 1.8% | 7,692,750 |  | Unchanged |
| GH RESEARCH PLC | Common Stock | $205.3m | 1.8% | 7,636,813 |  | Reduced −39,884 |
| [DISC MEDICINE INC (IRON)](/companies/iron.md) | Common Stock | $179.2m | 1.6% | 2,450,221 |  | Unchanged |
| [SPYGLASS PHARMA INC (SGP)](/companies/sgp.md) | Common Stock | $178.6m | 1.6% | 8,021,117 |  | Unchanged |
| [ARTIVA BIOTHERAPEUTICS INC (ARTV)](/companies/artv.md) | Common Stock | $174.2m | 1.5% | 17,955,642 |  | Added +8,102,340 |
| [JANUX THERAPEUTICS INC (JANX)](/companies/janx.md) | Common Stock | $171.9m | 1.5% | 11,189,693 |  | Unchanged |
| [TAYSHA GENE THERAPIES INC (TSHA)](/companies/tsha.md) | Common Stock | $160.4m | 1.4% | 23,555,648 |  | Unchanged |
| [BIOCRYST PHARMACEUTICALS INC (BCRX)](/companies/bcrx.md) | Common Stock | $158.3m | 1.4% | 15,827,186 |  | Unchanged |
| WAVE LIFE SCIENCES LTD | Common Stock | $156.7m | 1.4% | 26,975,505 |  | Unchanged |
| NUVALENT INC-A | Common Stock | $153.9m | 1.3% | 1,246,456 |  | Reduced −1,287,689 |
| [ABIVAX SA-ADR (ABVX)](/companies/abvx.md) | ADR | $150.9m | 1.3% | 1,132,557 |  | New +1,132,557 |
| [ORUKA THERAPEUTICS INC (ORKA)](/companies/orka.md) | Common Stock | $148.0m | 1.3% | 1,554,597 |  | New +1,554,597 |
| [CLIMB BIO INC (CLYM)](/companies/clym.md) | Common Stock | $147.4m | 1.3% | 11,300,939 |  | Unchanged |
| [SOLID BIOSCIENCES INC (SLDB)](/companies/sldb.md) | Common Stock | $120.2m | 1.0% | 12,036,126 |  | Added +2,696,148 |
| [ZAI LAB LTD-ADR (ZLAB)](/companies/zlab.md) | ADR | $109.1m | 0.9% | 5,743,533 |  | Added +36,271 |
| [ARS PHARMACEUTICALS INC (SPRY)](/companies/spry.md) | Common Stock | $87.0m | 0.8% | 10,860,977 |  | Unchanged |
| [XENCOR INC (XNCR)](/companies/xncr.md) | Common Stock | $84.9m | 0.7% | 5,274,274 |  | Added +377,037 |
| [JADE BIOSCIENCES INC (JBIO)](/companies/jbio.md) | Common Stock | $81.6m | 0.7% | 3,671,083 |  | Unchanged |
| [INTELLIA THERAPEUTICS INC (NTLA)](/companies/ntla.md) | Common Stock | $76.6m | 0.7% | 4,526,926 |  | New +4,526,926 |
| [LB PHARMACEUTICALS INC (LBRX)](/companies/lbrx.md) | Common Stock | $71.7m | 0.6% | 2,208,604 |  | Unchanged |
| [DEFINIUM THERAPEUTICS INC (DFTX)](/companies/dftx.md) | Common Stock | $70.6m | 0.6% | 1,500,000 |  | New +1,500,000 |
| [ACLARIS THERAPEUTICS INC (ACRS)](/companies/acrs.md) | Common Stock | $67.3m | 0.6% | 12,723,026 |  | Added +5,918,954 |
| [4D MOLECULAR THERAPEUTICS IN (FDMT)](/companies/fdmt.md) | Common Stock | $67.2m | 0.6% | 5,049,779 |  | Unchanged |
| [SANA BIOTECHNOLOGY INC (SANA)](/companies/sana.md) | Common Stock | $65.4m | 0.6% | 18,750,000 |  | New +18,750,000 |
| DAMORA THERAPEUTICS INC | Common Stock | $62.4m | 0.5% | 2,399,702 |  | Added +392 |
| [MONOPAR THERAPEUTICS INC (MNPR)](/companies/mnpr.md) | Common Stock | $61.8m | 0.5% | 667,207 |  | Unchanged |
| [ACUMEN PHARMACEUTICALS INC (ABOS)](/companies/abos.md) | Common Stock | $56.1m | 0.5% | 20,992,669 |  | Unchanged |
| [GERON CORP (GERN)](/companies/gern.md) | Common Stock | $54.8m | 0.5% | 42,809,751 |  | Reduced −20,961,615 |
| [REZOLUTE INC (RZLT)](/companies/rzlt.md) | Common Stock | $49.1m | 0.4% | 9,445,039 |  | Added +265,039 |
| [EVOMMUNE INC (EVMN)](/companies/evmn.md) | Common Stock | $46.4m | 0.4% | 3,494,638 |  | Unchanged |
| [VOR BIOPHARMA INC (VOR)](/companies/vor.md) | Common Stock | $44.2m | 0.4% | 2,402,095 |  | Reduced −3,002,903 |
| [CENTURY THERAPEUTICS INC (IPSC)](/companies/ipsc.md) | Common Stock | $43.5m | 0.4% | 17,754,430 |  | Unchanged |
| [AKTIS ONCOLOGY INC (AKTS)](/companies/akts.md) | Common Stock | $42.4m | 0.4% | 1,314,405 |  | Reduced −188,679 |
| [BIOAGE LABS INC (BIOA)](/companies/bioa.md) | Common Stock | $41.0m | 0.4% | 1,671,648 |  | Added +21,000 |
| [C4 THERAPEUTICS INC (CCCC)](/companies/cccc.md) | Common Stock | $37.4m | 0.3% | 8,000,000 |  | Unchanged |
| [MIRUM PHARMACEUTICALS INC (MIRM)](/companies/mirm.md) | Common Stock | $37.3m | 0.3% | 318,554 |  | Unchanged |
| [CAPRICOR THERAPEUTICS INC (CAPR)](/companies/capr.md) | Common Stock | $36.3m | 0.3% | 1,507,844 |  | Unchanged |
| [PEPGEN INC (PEPG)](/companies/pepg.md) | Common Stock | $36.1m | 0.3% | 20,064,545 |  | Unchanged |
| [PRELUDE THERAPEUTICS INC (PRLD)](/companies/prld.md) | Common Stock | $34.5m | 0.3% | 6,475,882 |  | New +6,475,882 |
| [NKARTA INC (NKTX)](/companies/nktx.md) | Common Stock | $30.6m | 0.3% | 10,805,129 |  | Unchanged |
| [Q32 BIO INC (QTTB)](/companies/qttb.md) | Common Stock | $29.7m | 0.3% | 2,332,457 |  | New +2,332,457 |
| [ANTERIS TECHNOLOGIES GLOBAL (AVR)](/companies/avr.md) | Common Stock | $29.6m | 0.3% | 3,000,000 |  | Unchanged |
| [EDITAS MEDICINE INC (EDIT)](/companies/edit.md) | Common Stock | $28.8m | 0.3% | 8,889,000 |  | New +8,889,000 |
| [OVID THERAPEUTICS INC (OVID)](/companies/ovid.md) | Common Stock | $28.2m | 0.2% | 10,500,968 |  | Reduced −213,032 |
| [ASSEMBLY BIOSCIENCES INC (ASMB)](/companies/asmb.md) | Common Stock | $28.0m | 0.2% | 1,020,410 |  | Unchanged |
| [ALX ONCOLOGY HOLDINGS INC (ALXO)](/companies/alxo.md) | Common Stock | $26.9m | 0.2% | 13,011,849 |  | Unchanged |
| [BENITEC BIOPHARMA INC (BNTC)](/companies/bntc.md) | Common Stock | $24.8m | 0.2% | 1,850,000 |  | Unchanged |
| [LENZ THERAPEUTICS INC (LENZ)](/companies/lenz.md) | Common Stock | $23.7m | 0.2% | 4,178,823 |  | Unchanged |
| [LEXEO THERAPEUTICS INC (LXEO)](/companies/lxeo.md) | Common Stock | $23.3m | 0.2% | 5,000,000 |  | Unchanged |
| [ACRIVON THERAPEUTICS INC (ACRV)](/companies/acrv.md) | Common Stock | $21.8m | 0.2% | 12,229,396 |  | Added +3,888,888 |
| [ALTIMMUNE INC (ALT)](/companies/alt.md) | Common Stock | $19.8m | 0.2% | 6,500,000 |  | New +6,500,000 |
| [KARYOPHARM THERAPEUTICS INC (KPTI)](/companies/kpti.md) | Common Stock | $18.7m | 0.2% | 1,917,354 |  | Unchanged |
| [BRIGHT MINDS BIOSCIENCES INC (DRUG)](/companies/drug.md) | Common Stock | $18.6m | 0.2% | 265,000 |  | Unchanged |
| [AVALO THERAPEUTICS INC (AVTX)](/companies/avtx.md) | Common Stock | $18.5m | 0.2% | 1,000,000 |  | Added +337,032 |
| [ONKURE THERAPEUTICS INC-A (OKUR)](/companies/okur.md) | Common Stock | $18.2m | 0.2% | 3,998,333 |  | Unchanged |
| [FAETH THERAPEUTICS INC (FTH)](/companies/fth.md) | Common Stock | $18.1m | 0.2% | 722,020 |  | New +722,020 |
| [AURA BIOSCIENCES INC (AURA)](/companies/aura.md) | Common Stock | $17.8m | 0.2% | 2,500,000 |  | New +2,500,000 |
| [SAB BIOTHERAPEUTICS INC (SABS)](/companies/sabs.md) | Common Stock | $17.2m | 0.1% | 4,401,500 |  | Unchanged |
| [SEAPORT THERAPEUTICS INC (SPTX)](/companies/sptx.md) | Common Stock | $15.2m | 0.1% | 700,000 |  | New +700,000 |
| [PALISADE BIO INC (PALI)](/companies/pali.md) | Common Stock | $14.9m | 0.1% | 7,124,116 |  | Unchanged |
| HELIX ACQUISITION CORP-CL A | Common Stock | $13.3m | 0.1% | 1,250,000 |  | Unchanged |
| [WAYSTAR HOLDING CORP (WAY)](/companies/way.md) | Common Stock | $10.9m | <0.1% | 529,400 |  | Unchanged |
| [EQUILLIUM INC (EQ)](/companies/eq.md) | Common Stock | $9.9m | <0.1% | 3,096,336 |  | Unchanged |
| [MACROGENICS INC (MGNX)](/companies/mgnx.md) | Common Stock | $8.6m | <0.1% | 1,864,176 |  | Unchanged |
| PERCEPTIVE CAPITAL SOLUTIONS | Common Stock | $8.2m | <0.1% | 750,000 |  | Unchanged |
| [ADICET BIO INC (ACET)](/companies/acet.md) | Common Stock | $8.1m | <0.1% | 932,624 |  | Reduced −250,000 |
| NEWAMSTERDAM PHARMA CO NV-27 | WTS | $7.1m | <0.1% | 333,333 |  | Unchanged |
| [CORVUS PHARMACEUTICALS INC (CRVS)](/companies/crvs.md) | Common Stock | $6.7m | <0.1% | 450,000 |  | Unchanged |
| [RANI THERAPEUTICS HOLDINGS-A (RANI)](/companies/rani.md) | Common Stock | $6.5m | <0.1% | 8,500,000 |  | Unchanged |
| JATT II ACQUISITION CORP | Common Stock | $5.7m | <0.1% | 500,000 |  | New +500,000 |
| AMANAT ACQUISITION CORP CL A | Common Stock | $3.8m | <0.1% | 375,000 |  | New +375,000 |
| [WEREWOLF THERAPEUTICS INC (HOWL)](/companies/howl.md) | Common Stock | $859.3k | <0.1% | 2,387,744 |  | Reduced −4,293,563 |
| [PALATIN TECHNOLOGIES INC (PTN)](/companies/ptn.md) | Common Stock | $670.3k | <0.1% | 62,124 |  | Reduced −7,876 |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| ASCENDIS PHARMA A/S - ADR | SPONSORED ADR | $0 | 0.0% | 0 |  | Sold out −10,281,496 |
| [ATRIUM THERAPEUTICS INC (RNA)](/companies/rna.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −864,102 |
| [CONTINEUM THERAPEUTICS INC-A (CTNM)](/companies/ctnm.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −1,296,012 |
| [DESIGN THERAPEUTICS INC (DSGN)](/companies/dsgn.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −2,972,973 |
| [DIANTHUS THERAPEUTICS INC (DNTH)](/companies/dnth.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −2,611,733 |
| [FULCRUM THERAPEUTICS INC (FULC)](/companies/fulc.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −6,053,960 |
| [GENEDX HOLDINGS CORP (WGS)](/companies/wgs.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −209,887 |
| [GRAIL INC (GRAL)](/companies/gral.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −428,266 |
| [HINGE HEALTH INC-A (HNGE)](/companies/hnge.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −364,613 |
| [INSPIRE MEDICAL SYSTEMS INC (INSP)](/companies/insp.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −325,663 |
| [MAPLIGHT THERAPEUTICS INC (MPLT)](/companies/mplt.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −248,294 |
| [OLEMA PHARMACEUTICALS INC (OLMA)](/companies/olma.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −2,600,000 |
| [PRAXIS PRECISION MEDICINES I (PRAX)](/companies/prax.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −373,787 |
| [RELMADA THERAPEUTICS INC (RLMD)](/companies/rlmd.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −2,947,369 |
| [SAREPTA THERAPEUTICS INC (SRPT)](/companies/srpt.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −3,902,596 |
| [SPYRE THERAPEUTICS INC (SYRE)](/companies/syre.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −1,621,620 |
| [SUTRO BIOPHARMA INC (STRO)](/companies/stro.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −715,307 |
| [TRAVERE THERAPEUTICS INC (TVTX)](/companies/tvtx.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −746,841 |

Source: SEC EDGAR, Form 13F-HR, accession 0001104659-26-097251. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.