# DAFNA Capital Management LLC: Form 13F holdings

An institutional investment manager in LOS ANGELES, CA. SEC CIK 1389933.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $524.4m
- Positions: 88 (88 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1389933/000138993326000006/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [REVOLUTION MEDICINES INC (RVMD)](/companies/rvmd.md) | COM | $105.4m | 20.1% | 562,630 |  | Reduced −18,048 |
| SPDR S&P BIOTECH ETF | ETF | $31.1m | 5.9% | 196,505 |  | Reduced −122,000 |
| [COMPASS PATHWAYS PLC (CMPS)](/companies/cmps.md) | SPONSORED ADS | $28.5m | 5.4% | 2,011,952 |  | Reduced −406,930 |
| [STEREOTAXIS INC (STXS)](/companies/stxs.md) | COM NEW | $23.5m | 4.5% | 13,680,554 |  | Unchanged |
| [NEKTAR THERAPEUTICS (NKTR)](/companies/nktr.md) | COM NEW | $22.2m | 4.2% | 318,380 |  | Added +153,202 |
| [DENALI THERAPEUTICS INC (DNLI)](/companies/dnli.md) | COM | $19.0m | 3.6% | 739,014 |  | Added +420,514 |
| [IDEAYA BIOSCIENCES INC (IDYA)](/companies/idya.md) | COM | $18.5m | 3.5% | 497,240 |  | Added +20,500 |
| [ATRICURE INC (ATRC)](/companies/atrc.md) | COM | $16.7m | 3.2% | 597,431 |  | Unchanged |
| [XENON PHARMACEUTICALS INC (XENE)](/companies/xene.md) | COM | $15.1m | 2.9% | 250,772 |  | Unchanged |
| [CYTOKINETICS INC (CYTK)](/companies/cytk.md) | COM NEW | $14.7m | 2.8% | 171,998 |  | Reduced −45,499 |
| [ARCUS BIOSCIENCES INC (RCUS)](/companies/rcus.md) | COM | $13.6m | 2.6% | 441,829 |  | Reduced −2,000 |
| ASCENDIS PHARMA A/S | ORD SHS | $12.9m | 2.5% | 48,469 |  | New +48,469 |
| [NEUROCRINE BIOSCIENCES INC (NBIX)](/companies/nbix.md) | COM | $9.7m | 1.9% | 57,769 |  | Reduced −12,846 |
| [AXOGEN INC (AXGN)](/companies/axgn.md) | COM | $9.7m | 1.8% | 208,960 |  | Reduced −41,000 |
| [INSULET CORP (PODD)](/companies/podd.md) | COM | $9.4m | 1.8% | 61,870 |  | Added +51,000 |
| [EDGEWISE THERAPEUTICS INC (EWTX)](/companies/ewtx.md) | COM | $9.2m | 1.8% | 226,819 |  | Added +114,583 |
| [BICARA THERAPEUTICS INC (BCAX)](/companies/bcax.md) | COM | $8.5m | 1.6% | 284,955 |  | Reduced −136,778 |
| ISHARES NASDAQ BIOTECH INDX | ETF | $8.1m | 1.5% | 42,595 |  | Reduced −19,500 |
| [SYNDAX PHARMACEUTICALS INC (SNDX)](/companies/sndx.md) | COM | $7.3m | 1.4% | 335,255 |  | Added +117,900 |
| [MAPLIGHT THERAPEUTICS INC (MPLT)](/companies/mplt.md) | COM | $6.1m | 1.2% | 171,006 |  | Unchanged |
| [LARIMAR THERAPEUTICS INC (LRMR)](/companies/lrmr.md) | COM | $6.1m | 1.2% | 2,008,164 |  | Reduced −21,000 |
| [CENTURY THERAPEUTICS INC (IPSC)](/companies/ipsc.md) | COM | $5.9m | 1.1% | 2,400,458 |  | Reduced −33,895 |
| [DEXCOM INC (DXCM)](/companies/dxcm.md) | COM | $5.8m | 1.1% | 86,279 |  | Unchanged |
| [IMMUNOVANT INC (IMVT)](/companies/imvt.md) | COM | $5.8m | 1.1% | 149,524 |  | Reduced −1,000 |
| [INOGEN INC (INGN)](/companies/ingn.md) | COM | $5.5m | 1.0% | 845,179 |  | Unchanged |
| [TANDEM DIABETES CARE INC (TNDM)](/companies/tndm.md) | COM | $5.4m | 1.0% | 355,208 |  | Unchanged |
| ALKERMES PLC | SHS | $5.3m | 1.0% | 101,266 |  | Reduced −38,216 |
| [STOKE THERAPEUTICS INC (STOK)](/companies/stok.md) | COM | $4.3m | 0.8% | 130,875 |  | Unchanged |
| [ALLOGENE THERAPEUTICS INC (ALLO)](/companies/allo.md) | COM | $4.2m | 0.8% | 2,000,000 |  | Added +629,882 |
| [BIOCRYST PHARMACEUTICALS INC (BCRX)](/companies/bcrx.md) | COM | $4.0m | 0.8% | 400,248 |  | Reduced −30,000 |
| [LAKEFRONT BIOTHERAPEUTICS NV (LKFT)](/companies/lkft.md) | SPON ADR | $3.9m | 0.7% | 130,175 |  | Unchanged |
| [ORTHOPEDIATRICS CORP (KIDS)](/companies/kids.md) | COM | $3.6m | 0.7% | 189,130 |  | Added +93,471 |
| CYBIN INC | COM NEW | $3.4m | 0.6% | 514,061 |  | Added +15,700 |
| [RAPPORT THERAPEUTICS INC (RAPP)](/companies/rapp.md) | COM | $3.1m | 0.6% | 75,000 |  | Unchanged |
| [KYMERA THERAPEUTICS INC (KYMR)](/companies/kymr.md) | COM | $3.1m | 0.6% | 27,000 |  | New +27,000 |
| PROQR THERAPEUTICS NV | SHS EURO | $2.8m | 0.5% | 1,530,361 |  | Reduced −37,200 |
| [NEUROGENE INC (NGNE)](/companies/ngne.md) | COM | $2.8m | 0.5% | 89,032 |  | Added +32,397 |
| [ADLAI NORTYE LTD (ANL)](/companies/anl.md) | SPONSORED ADS | $2.8m | 0.5% | 239,553 |  | New +239,553 |
| [PROCEPT BIOROBOTICS CORP (PRCT)](/companies/prct.md) | COM | $2.7m | 0.5% | 120,000 |  | Unchanged |
| [AQUESTIVE THERAPEUTICS INC (AQST)](/companies/aqst.md) | COM | $2.7m | 0.5% | 645,915 |  | Added +277,500 |
| [CELLDEX THERAPEUTICS INC (CLDX)](/companies/cldx.md) | COM NEW | $2.5m | 0.5% | 68,518 |  | Unchanged |
| [STRUCTURE THERAPEUTICS INC (GPCR)](/companies/gpcr.md) | SPONSORED ADS | $2.5m | 0.5% | 46,500 |  | Unchanged |
| [ALIGN TECHNOLOGY INC (ALGN)](/companies/algn.md) | COM | $2.4m | 0.5% | 14,000 |  | Reduced −1,000 |
| [VIKING THERAPEUTICS INC (VKTX)](/companies/vktx.md) | COM | $2.3m | 0.4% | 59,516 |  | Unchanged |
| [NERVGEN PHARMA CORP (NGEN)](/companies/ngen.md) | COM | $2.2m | 0.4% | 1,050,000 |  | New +1,050,000 |
| BIOHAVEN LTD | COM | $2.0m | 0.4% | 137,593 |  | Reduced −708,142 |
| [MAZE THERAPEUTICS INC (MAZE)](/companies/maze.md) | COM | $1.9m | 0.4% | 65,000 |  | Added +30,000 |
| [ALECTOR INC (ALEC)](/companies/alec.md) | COM | $1.8m | 0.3% | 908,351 |  | Unchanged |
| [LEXEO THERAPEUTICS INC (LXEO)](/companies/lxeo.md) | COM | $1.8m | 0.3% | 377,059 |  | Unchanged |
| [PROFOUND MEDICAL CORP (PROF)](/companies/prof.md) | COM NEW | $1.7m | 0.3% | 260,360 |  | Reduced −2,645 |
| [ATRIUM THERAPEUTICS INC (RNA)](/companies/rna.md) | COM | $1.7m | 0.3% | 128,000 |  | New +128,000 |
| [ANNEXON INC (ANNX)](/companies/annx.md) | COM | $1.7m | 0.3% | 297,812 |  | Added +180,000 |
| [CYTOMX THERAPEUTICS INC (CTMX)](/companies/ctmx.md) | COM | $1.6m | 0.3% | 438,407 |  | Added +208,407 |
| [ULTRAGENYX PHARMACEUTICAL INC (RARE)](/companies/rare.md) | COM | $1.6m | 0.3% | 47,100 |  | Reduced −14,000 |
| [EUPRAXIA PHARMACEUTICALS INC (EPRX)](/companies/eprx.md) | COM | $1.5m | 0.3% | 225,600 |  | New +225,600 |
| [DESIGN THERAPEUTICS INC (DSGN)](/companies/dsgn.md) | COM | $1.5m | 0.3% | 102,600 |  | New +102,600 |
| [FATE THERAPEUTICS INC (FATE)](/companies/fate.md) | COM | $1.4m | 0.3% | 525,000 |  | Reduced −25,000 |
| MEDIWOUND LTD | SHS NEW | $1.4m | 0.3% | 94,405 |  | Unchanged |
| [KURA ONCOLOGY INC (KURA)](/companies/kura.md) | COM | $1.3m | 0.3% | 120,568 |  | Reduced −115,300 |
| [ARS PHARMACEUTICALS INC (SPRY)](/companies/spry.md) | COM | $1.3m | 0.3% | 164,285 |  | Added +25,000 |
| [MINERALYS THERAPEUTICS INC (MLYS)](/companies/mlys.md) | COM | $1.2m | 0.2% | 44,490 |  | Added +6,000 |
| IMMATICS NV | SHS | $1.2m | 0.2% | 116,960 |  | Reduced −108,900 |
| [TELA BIO INC (TELA)](/companies/tela.md) | COM | $1.1m | 0.2% | 1,441,029 |  | Unchanged |
| POLYPID LTD | COM | $1.1m | 0.2% | 207,900 |  | Unchanged |
| [CORBUS PHARMACEUTICALS HLDGS (CRBP)](/companies/crbp.md) | COM NEW | $1.0m | 0.2% | 107,773 |  | New +107,773 |
| [INSPIRE MEDICAL SYSTEMS INC (INSP)](/companies/insp.md) | COM | $811.9k | 0.2% | 18,200 |  | Unchanged |
| [ADICET BIO INC (ACET)](/companies/acet.md) | COM NEW | $810.5k | 0.2% | 93,812 |  | Unchanged |
| [SEAPORT THERAPEUTICS INC (SPTX)](/companies/sptx.md) | COMMON STOCK | $703.7k | 0.1% | 32,400 |  | New +32,400 |
| [MBX BIOSCIENCES INC (MBX)](/companies/mbx.md) | COM | $651.9k | 0.1% | 11,809 |  | Reduced −163,656 |
| [BIONTECH SE (BNTX)](/companies/bntx.md) | SPONSORED ADS | $651.4k | 0.1% | 7,000 |  | Unchanged |
| [ARTIVA BIOTHERAPEUTICS INC (ARTV)](/companies/artv.md) | COM | $650.9k | 0.1% | 67,101 |  | New +67,101 |
| [PLIANT THERAPEUTICS INC (PLRX)](/companies/plrx.md) | COM | $555.2k | 0.1% | 487,000 |  | Unchanged |
| [SCYNEXIS INC (SCYX)](/companies/scyx.md) | COM | $553.0k | 0.1% | 135,868 |  | New +135,868 |
| [EDITAS MEDICINE INC (EDIT)](/companies/edit.md) | COM | $552.3k | 0.1% | 170,470 |  | New +170,470 |
| [ORCHESTRA BIOMED HOLDINGS INC (OBIO)](/companies/obio.md) | COM | $547.3k | 0.1% | 126,841 |  | Unchanged |
| [FOGHORN THERAPEUTICS INC (FHTX)](/companies/fhtx.md) | COM | $545.9k | 0.1% | 111,859 |  | Unchanged |
| [ACCURAY INC (ARAY)](/companies/aray.md) | COM | $433.2k | <0.1% | 1,680,508 |  | Unchanged |
| [Q32 BIO INC (QTTB)](/companies/qttb.md) | COM | $419.1k | <0.1% | 32,896 |  | New +32,896 |
| [NUVECTIS PHARMA INC (NVCT)](/companies/nvct.md) | COM | $367.8k | <0.1% | 20,000 |  | New +20,000 |
| COMPUGEN LTD | ORD | $360.0k | <0.1% | 168,232 |  | Reduced −89,551 |
| [IBIO INC (IBIO)](/companies/ibio.md) | COM NEW | $297.6k | <0.1% | 170,053 |  | Reduced −23,585 |
| [AUTOLUS THERAPEUTICS LTD (AUTL)](/companies/autl.md) | SPON ADS | $286.9k | <0.1% | 179,316 |  | Unchanged |
| [BICYCLE THERAPEUTICS PLC (BCYC)](/companies/bcyc.md) | SPONSORED ADS | $273.4k | <0.1% | 64,492 |  | Unchanged |
| [TENAYA THERAPEUTICS INC (TNYA)](/companies/tnya.md) | COM | $221.7k | <0.1% | 300,000 |  | New +300,000 |
| [VERRICA PHARMACEUTICALS INC (VRCA)](/companies/vrca.md) | COM SHS | $145.3k | <0.1% | 23,750 |  | Reduced −129,962 |
| [ENGENE THERAPEUTICS INC (ENGN)](/companies/engn.md) | COM | $129.1k | <0.1% | 74,650 |  | New +74,650 |
| [KARDIGAN INC (KARD)](/companies/kard.md) | COM | $119.3k | <0.1% | 5,000 |  | New +5,000 |
| ADC THERAPEUTICS SA | SHS | $82.5k | <0.1% | 77,081 |  | Added +5,000 |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| ASCENDIS PHARMA A/S | SPONSORED ADR | $0 | 0.0% | 0 |  | Sold out −23,177 |
| ASCENDIS PHARMA A/S | NOTE 2.250% 4/0 | $0 | 0.0% | $0 principal |  | Sold out −4,000,000 |
| DAY ONE BIOPHARMACEUTICALS I | COM | $0 | 0.0% | 0 |  | Sold out −978,463 |
| ENGENE HOLDINGS INC | COM | $0 | 0.0% | 0 |  | Sold out −187,353 |
| [FULCRUM THERAPEUTICS INC (FULC)](/companies/fulc.md) | COM | $0 | 0.0% | 0 |  | Sold out −205,000 |
| KALVISTA PHARMACEUTICALS INC | COM | $0 | 0.0% | 0 |  | Sold out −267,402 |
| [KARYOPHARM THERAPEUTICS INC (KPTI)](/companies/kpti.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −45,800 |
| [NEUMORA THERAPEUTICS INC (NMRA)](/companies/nmra.md) | COM | $0 | 0.0% | 0 |  | Sold out −70,000 |
| NEWAMSTERDAM PHARMA CO | ORDINARY SHARES | $0 | 0.0% | 0 |  | Sold out −20,000 |
| [ORIC PHARMACEUTICALS INC (ORIC)](/companies/oric.md) | COM | $0 | 0.0% | 0 |  | Sold out −98,724 |
| SCYNEXIS INC | COM NEW | $0 | 0.0% | 0 |  | Sold out −1,086,956 |
| [ZENAS BIOPHARMA INC (ZBIO)](/companies/zbio.md) | COM | $0 | 0.0% | 0 |  | Sold out −42,500 |

Source: SEC EDGAR, Form 13F-HR, accession 0001389933-26-000006. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.