# PFM Health Sciences, LP: Form 13F holdings

An institutional investment manager in SAN FRANCISCO, CA. SEC CIK 1442756.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $1.17bn
- Positions: 98 (98 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1442756/000144275626000006/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| ASCENDIS PHARMA A/S | ORD SHS | $62.2m | 5.3% | 233,171 |  | New +233,171 |
| [AXSOME THERAPEUTICS INC. (AXSM)](/companies/axsm.md) | COM | $53.8m | 4.6% | 219,596 |  | Reduced −44,708 |
| [ELI LILLY & CO (LLY)](/companies/lly.md) | COM | $47.1m | 4.0% | 39,258 |  | Reduced −26,504 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | $38.7m | 3.3% | 160,768 |  | Reduced −17,376 |
| [HUMANA INC (HUM)](/companies/hum.md) | COM | $37.5m | 3.2% | 94,375 |  | New +94,375 |
| [UNITEDHEALTH GROUP INC (UNH)](/companies/unh.md) | COM | $36.7m | 3.1% | 88,276 |  | Added +30,238 |
| [NEUROCRINE BIOSCIENCES INC (NBIX)](/companies/nbix.md) | COM | $36.0m | 3.1% | 213,407 |  | Reduced −2,271 |
| [INHIBRX BIOSCIENCES INC (INBX)](/companies/inbx.md) | COM | $29.2m | 2.5% | 308,385 |  | Added +2,954 |
| [UNITED THERAPEUTICS CORP DEL (UTHR)](/companies/uthr.md) | COM | $27.1m | 2.3% | 49,991 |  | Added +10,186 |
| [REVOLUTION MEDICINES INC (RVMD)](/companies/rvmd.md) | COM | $26.8m | 2.3% | 143,222 |  | Added +2,452 |
| ICON PUB LTD CO | SHS | $23.7m | 2.0% | 136,482 |  | Added +78,982 |
| [TENET HEALTHCARE CORP (THC)](/companies/thc.md) | COM NEW | $23.7m | 2.0% | 126,572 |  | Reduced −271,995 |
| [EDWARDS LIFESCIENCES CORP (EW)](/companies/ew.md) | COM | $22.7m | 1.9% | 250,453 |  | Reduced −4,057 |
| [WATERS CORP (WAT)](/companies/wat.md) | COM | $22.4m | 1.9% | 59,825 |  | Added +20,062 |
| [PENUMBRA INC (PEN)](/companies/pen.md) | COM | $19.0m | 1.6% | 60,221 |  | Reduced −79,558 |
| [BRIDGEBIO PHARMA INC (BBIO)](/companies/bbio.md) | COM | $18.9m | 1.6% | 253,358 |  | Reduced −4,389 |
| [STRYKER CORPORATION (SYK)](/companies/syk.md) | COM | $17.8m | 1.5% | 56,637 |  | Added +34,680 |
| [METTLER TOLEDO INTERNATIONAL (MTD)](/companies/mtd.md) | COM | $17.0m | 1.5% | 13,344 |  | New +13,344 |
| [INDIVIOR PHARMACEUTICALS INC (INDV)](/companies/indv.md) | COM | $16.5m | 1.4% | 401,208 |  | Reduced −173,458 |
| [MERCK & CO INC (MRK)](/companies/mrk.md) | COM | $16.3m | 1.4% | 127,118 |  | New +127,118 |
| [CYTOKINETICS INC (CYTK)](/companies/cytk.md) | COM NEW | $16.3m | 1.4% | 191,686 |  | New +191,686 |
| [LANTHEUS HLDGS INC (LNTH)](/companies/lnth.md) | COM | $16.2m | 1.4% | 146,403 |  | New +146,403 |
| [CENTENE CORP DEL (CNC)](/companies/cnc.md) | COM | $16.0m | 1.4% | 248,867 |  | Reduced −14,619 |
| [COOPER COS INC (COO)](/companies/coo.md) | COM | $15.8m | 1.4% | 220,890 |  | Added +51,061 |
| [MADRIGAL PHARMACEUTICALS INC (MDGL)](/companies/mdgl.md) | COM | $15.7m | 1.4% | 29,313 |  | Reduced −4,833 |
| [ACADIA HEALTHCARE COMPANY IN (ACHC)](/companies/achc.md) | COM | $15.5m | 1.3% | 524,934 |  | Reduced −57,811 |
| [ORUKA THERAPEUTICS INC (ORKA)](/companies/orka.md) | COM | $15.1m | 1.3% | 158,825 |  | Reduced −15,227 |
| [OSCAR HEALTH INC (OSCR)](/companies/oscr.md) | CL A | $14.8m | 1.3% | 519,016 |  | Added +19,179 |
| [THERMO FISHER SCIENTIFIC INC (TMO)](/companies/tmo.md) | COM | $14.3m | 1.2% | 28,496 |  | Added +13,664 |
| [CVS HEALTH CORP (CVS)](/companies/cvs.md) | COM | $14.2m | 1.2% | 137,457 |  | New +137,457 |
| [MERIT MED SYS INC (MMSI)](/companies/mmsi.md) | COM | $13.7m | 1.2% | 197,038 |  | Added +34,569 |
| [PRAXIS PRECISION MEDICINES I (PRAX)](/companies/prax.md) | COM NEW | $12.9m | 1.1% | 38,575 |  | Added +3,137 |
| [CELLDEX THERAPEUTICS INC NEW (CLDX)](/companies/cldx.md) | COM NEW | $12.8m | 1.1% | 342,751 |  | Added +17,794 |
| [NOVO-NORDISK A S (NVO)](/companies/nvo.md) | ADR | $12.7m | 1.1% | 265,016 |  | Added +67,835 |
| [INTEGER HLDGS CORP (ITGR)](/companies/itgr.md) | COM | $11.8m | 1.0% | 126,669 |  | Reduced −8,412 |
| [DIANTHUS THERAPEUTICS INC (DNTH)](/companies/dnth.md) | COM | $11.8m | 1.0% | 121,222 |  | Reduced −50,915 |
| [DEFINIUM THERAPEUTICS INC (DFTX)](/companies/dftx.md) | COM SHS | $11.7m | 1.0% | 249,020 |  | Added +43,703 |
| [GILEAD SCIENCES INC (GILD)](/companies/gild.md) | COM | $11.5m | 1.0% | 90,858 |  | New +90,858 |
| [RHYTHM PHARMACEUTICALS INC (RYTM)](/companies/rytm.md) | COM | $11.3m | 1.0% | 101,550 |  | Reduced −35,071 |
| [SCHEIN HENRY INC (HSIC)](/companies/hsic.md) | COM | $11.2m | 1.0% | 134,423 |  | Reduced −18,691 |
| [ARROWHEAD PHARMACEUTICALS IN (ARWR)](/companies/arwr.md) | COM | $10.7m | 0.9% | 131,667 |  | Added +67,388 |
| [TANGO THERAPEUTICS INC (TNGX)](/companies/tngx.md) | COM | $10.2m | 0.9% | 326,047 |  | Reduced −80,198 |
| [TELEFLEX INCORPORATED (TFX)](/companies/tfx.md) | COM | $10.1m | 0.9% | 79,708 |  | New +79,708 |
| [VIKING THERAPEUTICS INC (VKTX)](/companies/vktx.md) | COM | $10.0m | 0.9% | 255,330 |  | Reduced −7,776 |
| [BRIGHTSPRING HEALTH SVCS INC (BTSG)](/companies/btsg.md) | COM | $9.9m | 0.8% | 141,914 |  | Reduced −45,421 |
| [VERA THERAPEUTICS INC (VERA)](/companies/vera.md) | CL A | $9.6m | 0.8% | 224,289 |  | Added +49,422 |
| ROIVANT SCIENCES LTD | SHS | $9.5m | 0.8% | 268,008 |  | Added +60,562 |
| [CG ONCOLOGY INC (CGON)](/companies/cgon.md) | COM | $9.1m | 0.8% | 128,286 |  | Reduced −37,639 |
| [AMNEAL PHARMACEUTICALS INC (AMRX)](/companies/amrx.md) | COM STK CL A | $8.3m | 0.7% | 480,715 |  | Reduced −449,381 |
| [EUPRAXIA PHARMACEUTICALS INC (EPRX)](/companies/eprx.md) | COM | $8.0m | 0.7% | 1,210,661 |  | Added +669,790 |
| [CENCORA INC (COR)](/companies/cor.md) | COM | $8.0m | 0.7% | 28,100 | Call | New +28,100 |
| [IRHYTHM HOLDINGS INC (IRTC)](/companies/irtc.md) | COM | $7.8m | 0.7% | 65,196 |  | New +65,196 |
| [KODIAK SCIENCES INC (KOD)](/companies/kod.md) | COM | $7.5m | 0.6% | 193,315 |  | Added +78,596 |
| [ABBOTT LABORATORIES (ABT)](/companies/abt.md) | COM | $7.5m | 0.6% | 82,230 |  | Reduced −58,202 |
| [WEST PHARMACEUTICAL SVSC INC (WST)](/companies/wst.md) | COM | $7.4m | 0.6% | 20,733 |  | New +20,733 |
| [TAKEDA PHARMACEUTICAL CO LTD (TAK)](/companies/tak.md) | SPONSORED ADS | $7.1m | 0.6% | 444,173 |  | New +444,173 |
| [HINGE HEALTH INC (HNGE)](/companies/hnge.md) | CL A | $6.9m | 0.6% | 82,860 |  | New +82,860 |
| [ARCUTIS BIOTHERAPEUTICS INC (ARQT)](/companies/arqt.md) | COM | $6.3m | 0.5% | 242,069 |  | New +242,069 |
| [INTEGRA LIFESCIENCES HLDGS C (IART)](/companies/iart.md) | COM NEW | $6.3m | 0.5% | 348,746 |  | New +348,746 |
| [ILLUMINA INC (ILMN)](/companies/ilmn.md) | COM | $6.2m | 0.5% | 35,040 |  | Added +6,171 |
| MEIRAGTX HLDGS PLC | COM | $6.2m | 0.5% | 455,286 |  | New +455,286 |
| OCULIS HOLDING AG | ORDINARY SHARES | $6.0m | 0.5% | 436,042 |  | New +436,042 |
| [NATERA INC (NTRA)](/companies/ntra.md) | COM | $6.0m | 0.5% | 22,077 |  | Reduced −37,927 |
| [ABIVAX SA (ABVX)](/companies/abvx.md) | SPONSORED ADS | $5.8m | 0.5% | 43,264 |  | Added +16,600 |
| [CENTENE CORP DEL (CNC)](/companies/cnc.md) | COM | $5.7m | 0.5% | 88,200 | Put | New +88,200 |
| [GUARDANT HEALTH INC (GH)](/companies/gh.md) | COM | $5.5m | 0.5% | 36,701 |  | New +36,701 |
| [CELCUITY INC (CELC)](/companies/celc.md) | COM | $5.5m | 0.5% | 52,155 |  | New +52,155 |
| [BELITE BIO INC (BLTE)](/companies/blte.md) | SPONSORED ADS | $5.4m | 0.5% | 34,803 |  | Reduced −24,629 |
| [STRUCTURE THERAPEUTICS INC (GPCR)](/companies/gpcr.md) | SPONSORED ADS | $4.9m | 0.4% | 91,550 |  | Reduced −34,833 |
| [ARCUS BIOSCIENCES INC (RCUS)](/companies/rcus.md) | COM | $4.7m | 0.4% | 152,129 |  | New +152,129 |
| [CHARLES RIV LABS INTL INC (CRL)](/companies/crl.md) | COM | $4.3m | 0.4% | 18,747 |  | New +18,747 |
| [ELANCO ANIMAL HEALTH INC (ELAN)](/companies/elan.md) | COM | $4.2m | 0.4% | 172,489 |  | New +172,489 |
| [ARGENX SE (ARGX)](/companies/argx.md) | SPONSORED ADR | $4.2m | 0.4% | 4,482 |  | Reduced −53 |
| [BIO RAD LABS INC (BIO)](/companies/bio.md) | CL A | $4.1m | 0.4% | 13,995 |  | New +13,995 |
| [SPYRE THERAPEUTICS INC (SYRE)](/companies/syre.md) | COM NEW | $4.1m | 0.4% | 46,217 |  | New +46,217 |
| [MBX BIOSCIENCES INC (MBX)](/companies/mbx.md) | COM | $3.9m | 0.3% | 70,971 |  | Reduced −923 |
| [MIRUM PHARMACEUTICALS INC (MIRM)](/companies/mirm.md) | COM | $3.7m | 0.3% | 31,536 |  | New +31,536 |
| [CULLINAN THERAPEUTICS INC (CGEM)](/companies/cgem.md) | COM | $3.5m | 0.3% | 192,442 |  | Reduced −34,964 |
| [COMPASS PATHWAYS PLC (CMPS)](/companies/cmps.md) | SPONSORED ADS | $3.5m | 0.3% | 247,589 |  | Reduced −1,119,510 |
| [HCA HEALTHCARE INC (HCA)](/companies/hca.md) | COM | $3.2m | 0.3% | 8,295 |  | Reduced −5,056 |
| [CAPRICOR THERAPEUTICS INC (CAPR)](/companies/capr.md) | COM NEW | $2.9m | 0.3% | 122,221 |  | Reduced −1,610 |
| [DENALI THERAPEUTICS INC (DNLI)](/companies/dnli.md) | COM | $2.6m | 0.2% | 100,966 |  | New +100,966 |
| [SYNDAX PHARMACEUTICALS INC (SNDX)](/companies/sndx.md) | COM | $2.6m | 0.2% | 118,422 |  | Reduced −126,599 |
| [AMYLYX PHARMACEUTICALS INC (AMLX)](/companies/amlx.md) | COM | $2.6m | 0.2% | 143,700 |  | Reduced −1,575 |
| [TARSUS PHARMACEUTICALS INC (TARS)](/companies/tars.md) | COM | $2.6m | 0.2% | 40,579 |  | Reduced −39,647 |
| [OUTSET MED INC (OM)](/companies/om.md) | COM NEW | $2.5m | 0.2% | 582,122 |  | Reduced −12,508 |
| [OMADA HEALTH INC (OMDA)](/companies/omda.md) | COM | $2.5m | 0.2% | 114,442 |  | New +114,442 |
| [ERASCA INC (ERAS)](/companies/eras.md) | COM | $2.5m | 0.2% | 134,088 |  | New +134,088 |
| [CENCORA INC (COR)](/companies/cor.md) | COM | $2.1m | 0.2% | 7,385 |  | New +7,385 |
| [BIOCRYST PHARMACEUTICALS INC (BCRX)](/companies/bcrx.md) | COM | $2.1m | 0.2% | 207,357 |  | New +207,357 |
| [OMNICELL COM (OMCL)](/companies/omcl.md) | COM | $2.0m | 0.2% | 49,040 |  | New +49,040 |
| [CVRX INC (CVRX)](/companies/cvrx.md) | COM | $1.9m | 0.2% | 369,572 |  | New +369,572 |
| [HIMS & HERS HEALTH INC (HIMS)](/companies/hims.md) | COM CL A | $1.7m | 0.1% | 49,454 |  | New +49,454 |
| [MINERALYS THERAPEUTICS INC (MLYS)](/companies/mlys.md) | COM | $1.7m | 0.1% | 62,418 |  | Reduced −80,259 |
| [TECTONIC THERAPEUTIC INC (TECX)](/companies/tecx.md) | COM | $1.6m | 0.1% | 45,631 |  | Reduced −498 |
| UNIQURE NV | SHS | $1.2m | 0.1% | 26,396 |  | Reduced −16,239 |
| [REZOLUTE INC (RZLT)](/companies/rzlt.md) | COM NEW | $661.9k | <0.1% | 127,289 |  | Reduced −1,437 |
| [CARIBOU BIOSCIENCES INC (CRBU)](/companies/crbu.md) | COM | $624.2k | <0.1% | 354,687 |  | Reduced −603,100 |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [ALIGNMENT HEALTHCARE INC (ALHC)](/companies/alhc.md) | COM | $0 | 0.0% | 0 |  | Sold out −359,826 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | $0 | 0.0% | 0 | Call | Sold out −22,400 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | $0 | 0.0% | 0 |  | Sold out −152,034 |
| ASCENDIS PHARMA A/S | NOTE 2.250% 4/0 | $0 | 0.0% | $0 principal |  | Sold out −11,505,000 |
| [BILLIONTOONE INC (BLLN)](/companies/blln.md) | CL A | $0 | 0.0% | 0 |  | Sold out −88,069 |
| [CARDINAL HEALTH INC (CAH)](/companies/cah.md) | COM | $0 | 0.0% | 0 |  | Sold out −31,941 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −528,224 |
| [DEXCOM INC (DXCM)](/companies/dxcm.md) | COM | $0 | 0.0% | 0 |  | Sold out −149,734 |
| [GLAUKOS CORP (GKOS)](/companies/gkos.md) | COM | $0 | 0.0% | 0 |  | Sold out −215,685 |
| [GLOBUS MED INC (GMED)](/companies/gmed.md) | CL A | $0 | 0.0% | 0 |  | Sold out −16,923 |
| [HCA HEALTHCARE INC (HCA)](/companies/hca.md) | COM | $0 | 0.0% | 0 | Put | Sold out −4,600 |
| [MEDLINE INC (MDLN)](/companies/mdln.md) | COM CL A | $0 | 0.0% | 0 |  | Sold out −86,777 |
| [NEOGENOMICS INC (NEO)](/companies/neo.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −1,784,552 |
| [PERSONALIS INC (PSNL)](/companies/psnl.md) | COM | $0 | 0.0% | 0 |  | Sold out −870,097 |
| SELECT SECTOR SPDR TR | STATE STREET HEA | $0 | 0.0% | 0 | Call | Sold out −238,900 |
| SOLENO THERAPEUTICS INC | COM | $0 | 0.0% | 0 |  | Sold out −248,180 |
| SPDR SERIES TRUST | STATE STREET SPD | $0 | 0.0% | 0 | Put | Sold out −455,300 |
| TERNS PHARMACEUTICALS INC | COM | $0 | 0.0% | 0 |  | Sold out −172,962 |
| [UNITED THERAPEUTICS CORP DEL (UTHR)](/companies/uthr.md) | COM | $0 | 0.0% | 0 | Put | Sold out −45,900 |
| [UNITED THERAPEUTICS CORP DEL (UTHR)](/companies/uthr.md) | COM | $0 | 0.0% | 0 | Call | Sold out −31,700 |

Source: SEC EDGAR, Form 13F-HR, accession 0001442756-26-000006. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.