# RTW INVESTMENTS, LP: Form 13F holdings

An institutional investment manager in NEW YORK, NY. SEC CIK 1493215.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $11.71bn
- Positions: 84 (84 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1493215/000149321526000164/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [MADRIGAL PHARMACEUTICALS INC (MDGL)](/companies/mdgl.md) | COM | $1.07bn | 9.1% | 1,993,687 |  | Unchanged |
| [ARGENX SE (ARGX)](/companies/argx.md) | SPONSORED ADR | $658.2m | 5.6% | 709,446 |  | Unchanged |
| [PTC THERAPEUTICS INC (PTCT)](/companies/ptct.md) | COM | $631.9m | 5.4% | 7,746,415 |  | Unchanged |
| [PROTAGONIST THERAPEUTICS INC (PTGX)](/companies/ptgx.md) | COM | $620.4m | 5.3% | 5,061,175 |  | Added +2,122 |
| [CG ONCOLOGY INC (CGON)](/companies/cgon.md) | COM | $605.0m | 5.2% | 8,514,590 |  | Added +1,529,782 |
| [INSMED INC (INSM)](/companies/insm.md) | COM PAR $.01 | $516.3m | 4.4% | 4,842,880 |  | Unchanged |
| [TANGO THERAPEUTICS INC (TNGX)](/companies/tngx.md) | COM | $434.5m | 3.7% | 13,900,620 |  | Added +600,000 |
| [SPYRE THERAPEUTICS INC (SYRE)](/companies/syre.md) | COM NEW | $377.5m | 3.2% | 4,251,996 |  | Added +80,000 |
| [CELCUITY INC (CELC)](/companies/celc.md) | COM | $345.8m | 3.0% | 3,304,903 |  | Added +265,282 |
| [ERASCA INC (ERAS)](/companies/eras.md) | COM | $328.8m | 2.8% | 17,946,754 |  | Added +1,789,579 |
| [RADNET INC (RDNT)](/companies/rdnt.md) | COM | $298.9m | 2.6% | 4,846,958 |  | Added +561,958 |
| [ORUKA THERAPEUTICS INC (ORKA)](/companies/orka.md) | COM | $298.7m | 2.6% | 3,139,030 |  | Added +1,080,882 |
| [NATERA INC (NTRA)](/companies/ntra.md) | COM | $271.4m | 2.3% | 1,000,000 |  | Reduced −250,000 |
| [ULTRAGENYX PHARMACEUTICAL IN (RARE)](/companies/rare.md) | COM | $260.3m | 2.2% | 7,796,895 |  | Added +4,148,100 |
| [IRHYTHM HOLDINGS INC (IRTC)](/companies/irtc.md) | COM | $259.6m | 2.2% | 2,182,631 |  | Added +514,131 |
| [CYTOKINETICS INC (CYTK)](/companies/cytk.md) | COM NEW | $243.8m | 2.1% | 2,862,003 |  | Added +140,845 |
| [KAILERA THERAPEUTICS INC (KLRA)](/companies/klra.md) | COMMON STOCK | $237.4m | 2.0% | 10,776,820 |  | New +10,776,820 |
| ESTABLISHMENT LABS HLDGS INC | COM | $227.9m | 1.9% | 2,655,695 |  | Unchanged |
| [GUARDANT HEALTH INC (GH)](/companies/gh.md) | COM | $222.2m | 1.9% | 1,481,033 |  | Unchanged |
| [NEUROCRINE BIOSCIENCES INC (NBIX)](/companies/nbix.md) | COM | $213.7m | 1.8% | 1,267,925 |  | Added +205,853 |
| [TARSUS PHARMACEUTICALS INC (TARS)](/companies/tars.md) | COM | $211.3m | 1.8% | 3,357,059 |  | Added +11,034 |
| [STOKE THERAPEUTICS INC (STOK)](/companies/stok.md) | COM | $184.0m | 1.6% | 5,623,525 |  | Unchanged |
| UNIQURE NV | SHS | $181.5m | 1.5% | 3,941,572 |  | Added +1,355,216 |
| [ACADIA PHARMACEUTICALS INC (ACAD)](/companies/acad.md) | COM | $180.8m | 1.5% | 7,144,524 |  | Unchanged |
| [REPLIGEN CORP (RGEN)](/companies/rgen.md) | COM | $169.3m | 1.4% | 1,240,637 |  | Added +34,637 |
| UROGEN PHARMA LTD | COM | $167.2m | 1.4% | 4,543,895 |  | Unchanged |
| GH RESEARCH PLC | ORDINARY SHARES | $159.5m | 1.4% | 5,933,815 |  | Unchanged |
| [IMMUNOCORE HLDGS PLC (IMCR)](/companies/imcr.md) | ADS | $154.6m | 1.3% | 4,869,798 |  | Unchanged |
| [COMPASS PATHWAYS PLC (CMPS)](/companies/cmps.md) | SPONSORED ADS | $151.4m | 1.3% | 10,700,974 |  | Added +68,584 |
| IMMATICS N.V | SHS | $131.1m | 1.1% | 12,946,176 |  | Added +76,836 |
| [ZAI LAB LTD (ZLAB)](/companies/zlab.md) | ADR | $124.9m | 1.1% | 6,574,032 |  | Unchanged |
| [IMMUNOVANT INC (IMVT)](/companies/imvt.md) | COM | $122.4m | 1.0% | 3,177,849 |  | Unchanged |
| [BELITE BIO INC (BLTE)](/companies/blte.md) | SPONSORED ADS | $110.2m | 0.9% | 715,332 |  | Unchanged |
| [XENCOR INC (XNCR)](/companies/xncr.md) | COM | $109.1m | 0.9% | 6,777,461 |  | Unchanged |
| [TAYSHA GENE THERAPIES INC (TSHA)](/companies/tsha.md) | COM SHS | $92.3m | 0.8% | 13,560,258 |  | Reduced −119,990 |
| [COGENT BIOSCIENCES INC (COGT)](/companies/cogt.md) | COM | $89.4m | 0.8% | 2,309,021 |  | Reduced −3,149,654 |
| ALKERMES PLC | SHS | $87.6m | 0.7% | 1,672,356 |  | Unchanged |
| [STRUCTURE THERAPEUTICS INC (GPCR)](/companies/gpcr.md) | SPONSORED ADS | $86.3m | 0.7% | 1,607,507 |  | New +1,607,507 |
| [REPLIMUNE GROUP INC (REPL)](/companies/repl.md) | COM | $82.0m | 0.7% | 7,411,581 |  | Added +54,665 |
| [CASTLE BIOSCIENCES INC (CSTL)](/companies/cstl.md) | COM | $66.3m | 0.6% | 2,778,335 |  | Added +20,000 |
| [CANDEL THERAPEUTICS INC (CADL)](/companies/cadl.md) | COM | $66.1m | 0.6% | 6,422,018 |  | Unchanged |
| [ROCKET PHARMACEUTICALS INC (RCKT)](/companies/rckt.md) | COM | $60.5m | 0.5% | 17,687,772 |  | Unchanged |
| [KODIAK SCIENCES INC (KOD)](/companies/kod.md) | COM | $58.0m | 0.5% | 1,487,934 |  | Unchanged |
| [AKTIS ONCOLOGY INC (AKTS)](/companies/akts.md) | COM | $51.3m | 0.4% | 1,592,043 |  | Unchanged |
| [AXOGEN INC (AXGN)](/companies/axgn.md) | COM | $46.7m | 0.4% | 1,011,576 |  | New +1,011,576 |
| [DANAHER CORP DEL (DHR)](/companies/dhr.md) | COM | $43.8m | 0.4% | 230,000 |  | New +230,000 |
| [CULLINAN THERAPEUTICS INC (CGEM)](/companies/cgem.md) | COM | $43.1m | 0.4% | 2,364,347 |  | Added +658,387 |
| [NEUROGENE INC (NGNE)](/companies/ngne.md) | COM | $42.8m | 0.4% | 1,362,456 |  | Unchanged |
| [HINGE HEALTH INC (HNGE)](/companies/hnge.md) | CL A | $41.5m | 0.4% | 500,000 |  | Reduced −1,430,000 |
| [ORCHESTRA BIOMED HLDGS INC (OBIO)](/companies/obio.md) | COM | $41.2m | 0.4% | 9,556,063 |  | Added +1,250,000 |
| [SOLID BIOSCIENCES INC (SLDB)](/companies/sldb.md) | COM NEW | $38.9m | 0.3% | 3,892,926 |  | New +3,892,926 |
| [SAVARA INC (SVRA)](/companies/svra.md) | COM | $36.7m | 0.3% | 5,952,380 |  | Unchanged |
| [AQUESTIVE THERAPEUTICS INC (AQST)](/companies/aqst.md) | COM | $30.9m | 0.3% | 7,426,471 |  | Unchanged |
| [KYMERA THERAPEUTICS INC (KYMR)](/companies/kymr.md) | COM | $27.5m | 0.2% | 240,000 |  | Unchanged |
| [VERASTEM INC (VSTM)](/companies/vstm.md) | COM NEW | $25.3m | 0.2% | 6,635,793 |  | Added +59,487 |
| [DIANTHUS THERAPEUTICS INC (DNTH)](/companies/dnth.md) | COM | $24.2m | 0.2% | 248,063 |  | Unchanged |
| [BETA BIONICS INC (BBNX)](/companies/bbnx.md) | COM | $23.5m | 0.2% | 1,500,000 |  | Reduced −500,000 |
| [CENTURY THERAPEUTICS INC (IPSC)](/companies/ipsc.md) | COM | $21.3m | 0.2% | 8,695,652 |  | Unchanged |
| [EVOMMUNE INC (EVMN)](/companies/evmn.md) | COM SHS | $20.0m | 0.2% | 1,502,235 |  | Unchanged |
| [BEAM THERAPEUTICS INC (BEAM)](/companies/beam.md) | COM | $19.6m | 0.2% | 570,394 |  | Unchanged |
| [DEFINIUM THERAPEUTICS INC (DFTX)](/companies/dftx.md) | COM SHS | $18.8m | 0.2% | 400,000 |  | Added +100,000 |
| [IDEAYA BIOSCIENCES INC (IDYA)](/companies/idya.md) | COM | $13.8m | 0.1% | 370,370 |  | New +370,370 |
| ATAIBECKLEY INC | COM SHS | $10.5m | <0.1% | 2,000,000 |  | Unchanged |
| [MILESTONE PHARMACEUTICALS IN (MIST)](/companies/mist.md) | COM | $10.5m | <0.1% | 7,833,336 |  | Added +1,502,335 |
| [OCUGEN INC (OCGN)](/companies/ocgn.md) | COM | $10.2m | <0.1% | 6,666,666 |  | Unchanged |
| [TENAX THERAPEUTICS INC (TENX)](/companies/tenx.md) | COM NEW | $10.1m | <0.1% | 696,570 |  | Added +326,324 |
| [HEARTFLOW INC (HTFL)](/companies/htfl.md) | COM | $8.7m | <0.1% | 295,000 |  | Reduced −200,000 |
| PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | $8.1m | <0.1% | 742,500 |  | Unchanged |
| WAVE LIFE SCIENCES LTD | SHS | $7.8m | <0.1% | 1,350,000 |  | Unchanged |
| [LARIMAR THERAPEUTICS INC (LRMR)](/companies/lrmr.md) | COM | $7.8m | <0.1% | 2,565,999 |  | Added +1,065,999 |
| [LUMEXA IMAGING HOLDINGS INC (LMRI)](/companies/lmri.md) | COM | $7.3m | <0.1% | 650,000 |  | Unchanged |
| [ALLOGENE THERAPEUTICS INC (ALLO)](/companies/allo.md) | COM | $6.8m | <0.1% | 3,250,000 |  | New +3,250,000 |
| CRESCENT BIOPHARMA INC. | COM | $6.7m | <0.1% | 372,856 |  | Unchanged |
| [4D MOLECULAR THERAPEUTICS IN (FDMT)](/companies/fdmt.md) | COM | $6.3m | <0.1% | 475,737 |  | Unchanged |
| [MAZE THERAPEUTICS INC (MAZE)](/companies/maze.md) | COM | $6.3m | <0.1% | 212,000 |  | New +212,000 |
| [CAPRICOR THERAPEUTICS INC (CAPR)](/companies/capr.md) | COM NEW | $6.0m | <0.1% | 250,000 |  | Unchanged |
| [KALARIS THERAPEUTICS INC (KLRS)](/companies/klrs.md) | COM | $5.3m | <0.1% | 1,300,000 |  | Unchanged |
| [ABIVAX SA (ABVX)](/companies/abvx.md) | SPONSORED ADS | $3.5m | <0.1% | 26,400 |  | New +26,400 |
| [AVALO THERAPEUTICS INC (AVTX)](/companies/avtx.md) | COM NEW | $3.2m | <0.1% | 175,000 |  | Reduced −681,962 |
| [MEDLINE INC (MDLN)](/companies/mdln.md) | COM CL A | $2.8m | <0.1% | 70,000 |  | Unchanged |
| [DISC MEDICINE INC (IRON)](/companies/iron.md) | COM | $2.2m | <0.1% | 30,000 |  | Unchanged |
| [IMAGENEBIO INC (IMA)](/companies/ima.md) | COM | $2.0m | <0.1% | 334,445 |  | Unchanged |
| [EXAGEN INC (XGN)](/companies/xgn.md) | COM | $906.8k | <0.1% | 195,000 |  | Reduced −200,231 |
| ROCKET PHARMACEUTICALS INC | \*W EXP 09/02/202 | $1.2k | <0.1% | 350,000 |  | Unchanged |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| APELLIS PHARMACEUTICALS INC | COM | $0 | 0.0% | 0 |  | Sold out −3,685,045 |
| APOGEE THERAPEUTICS INC | COM | $0 | 0.0% | 0 |  | Sold out −2,782,097 |
| [ARROWHEAD PHARMACEUTICALS IN (ARWR)](/companies/arwr.md) | COM | $0 | 0.0% | 0 |  | Sold out −585,682 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −2,054,175 |
| [COMPASS THERAPEUTICS INC (CMPX)](/companies/cmpx.md) | COM | $0 | 0.0% | 0 |  | Sold out −4,186,599 |
| CRINETICS PHARMACEUTICALS IN | COM | $0 | 0.0% | 0 |  | Sold out −1,451,326 |
| [FULGENT GENETICS INC (FLGT)](/companies/flgt.md) | COM | $0 | 0.0% | 0 |  | Sold out −1,289,000 |
| [INTUITIVE SURGICAL INC (ISRG)](/companies/isrg.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −220,000 |
| [INVENTIVA SA (IVA)](/companies/iva.md) | ADS | $0 | 0.0% | 0 |  | Sold out −1,298,702 |
| [JADE BIOSCIENCES INC (JBIO)](/companies/jbio.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −573,205 |
| [OMADA HEALTH INC (OMDA)](/companies/omda.md) | COM | $0 | 0.0% | 0 |  | Sold out −200,000 |
| [STRYKER CORPORATION (SYK)](/companies/syk.md) | COM | $0 | 0.0% | 0 |  | Sold out −100,000 |
| [WAYSTAR HLDG CORP (WAY)](/companies/way.md) | COM | $0 | 0.0% | 0 |  | Sold out −1,630,000 |

Source: SEC EDGAR, Form 13F-HR, accession 0001493215-26-000164. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.