# Opaleye Management Inc.: Form 13F holdings

An institutional investment manager in BOSTON, MA. SEC CIK 1595855.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $1.10bn
- Positions: 58 (58 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1595855/000142050626001803/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [LIQUIDIA CORPORATION (LQDA)](/companies/lqda.md) | COM NEW | $195.1m | 17.7% | 2,447,500 |  | Reduced −97,500 |
| [ETON PHARMACEUTICALS INC (ETON)](/companies/eton.md) | COM | $103.5m | 9.4% | 2,860,000 |  | Unchanged |
| [HARROW INC (HROW)](/companies/hrow.md) | COM | $101.9m | 9.2% | 2,400,000 |  | Reduced −432,230 |
| [DISC MEDICINE INC (IRON)](/companies/iron.md) | COM | $62.5m | 5.7% | 855,000 |  | Added +434,000 |
| UROGEN PHARMA LTD | COM | $53.0m | 4.8% | 1,439,996 |  | Added +9,996 |
| APOGEE THERAPEUTICS INC | COM | $51.8m | 4.7% | 390,000 |  | Unchanged |
| MEIRAGTX HLDGS PLC | COM | $48.0m | 4.3% | 3,550,000 |  | Added +1,426,741 |
| SOL-GEL TECHNOLOGIES LTD | SHS NEW | $37.1m | 3.4% | 500,000 |  | Unchanged |
| [REZOLUTE INC (RZLT)](/companies/rzlt.md) | COM NEW | $32.8m | 3.0% | 6,300,000 |  | Unchanged |
| [TG THERAPEUTICS INC (TGTX)](/companies/tgtx.md) | COM | $29.4m | 2.7% | 535,000 |  | Unchanged |
| [IMMIX BIOPHARMA INC (IMMX)](/companies/immx.md) | COM | $24.2m | 2.2% | 2,345,000 |  | New +2,345,000 |
| CRESCENT BIOPHARMA INC. | COM | $23.7m | 2.2% | 1,319,351 |  | Added +6,736 |
| [STOKE THERAPEUTICS INC (STOK)](/companies/stok.md) | COM | $22.9m | 2.1% | 700,000 |  | Unchanged |
| [ALPHA COGNITION INC (ACOG)](/companies/acog.md) | COM NEW | $20.9m | 1.9% | 2,895,467 |  | Added +333,517 |
| [EDGEWISE THERAPEUTICS INC (EWTX)](/companies/ewtx.md) | COM | $20.3m | 1.8% | 500,000 |  | Unchanged |
| [REVOLUTION MEDICINES INC (RVMD)](/companies/rvmd.md) | COM | $18.7m | 1.7% | 100,000 |  | Unchanged |
| [MONTE ROSA THERAPEUTICS INC (GLUE)](/companies/glue.md) | COM | $18.0m | 1.6% | 745,000 |  | New +745,000 |
| [ALUMIS INC (ALMS)](/companies/alms.md) | COM | $15.5m | 1.4% | 550,000 |  | Unchanged |
| [CODEXIS INC (CDXS)](/companies/cdxs.md) | COM | $15.3m | 1.4% | 6,785,000 |  | Unchanged |
| [REPLIMUNE GROUP INC (REPL)](/companies/repl.md) | COM | $15.3m | 1.4% | 1,384,993 |  | New +1,384,993 |
| XOMA ROYALTY CORPORATION | COM NEW | $14.4m | 1.3% | 338,374 |  | Added +38,374 |
| [MBX BIOSCIENCES INC (MBX)](/companies/mbx.md) | COM | $14.4m | 1.3% | 260,000 |  | Unchanged |
| [RHYTHM PHARMACEUTICALS INC (RYTM)](/companies/rytm.md) | COM | $13.6m | 1.2% | 122,500 |  | Reduced −500 |
| [EDITAS MEDICINE INC (EDIT)](/companies/edit.md) | COM | $12.5m | 1.1% | 3,861,930 |  | Added +1,934,933 |
| [PROTAGONIST THERAPEUTICS INC (PTGX)](/companies/ptgx.md) | COM | $12.3m | 1.1% | 100,000 |  | Unchanged |
| [CABALETTA BIO INC (CABA)](/companies/caba.md) | COM | $12.0m | 1.1% | 3,863,800 |  | Added +2,483,800 |
| [Q32 BIO INC (QTTB)](/companies/qttb.md) | COM | $11.9m | 1.1% | 931,000 |  | Reduced −325,228 |
| [ANNEXON INC (ANNX)](/companies/annx.md) | COM | $9.8m | 0.9% | 1,714,451 |  | Reduced −617,310 |
| [VERASTEM INC (VSTM)](/companies/vstm.md) | COM NEW | $6.9m | 0.6% | 1,800,000 |  | New +1,800,000 |
| [ZENTALIS PHARMACEUTICALS INC (ZNTL)](/companies/zntl.md) | COM | $6.9m | 0.6% | 1,412,656 |  | Unchanged |
| [RELMADA THERAPEUTICS INC (RLMD)](/companies/rlmd.md) | COM | $6.5m | 0.6% | 935,000 |  | Unchanged |
| [OCULAR THERAPEUTIX INC (OCUL)](/companies/ocul.md) | COM | $5.9m | 0.5% | 600,000 |  | Unchanged |
| [TREVI THERAPEUTICS INC (TRVI)](/companies/trvi.md) | COM | $5.8m | 0.5% | 310,000 |  | Reduced −35,100 |
| [BRIDGEBIO ONCOLOGY THERAPEUT (BBOT)](/companies/bbot.md) | COM NEW | $5.3m | 0.5% | 700,000 |  | Added +646,718 |
| [LYELL IMMUNOPHARMA INC (LYEL)](/companies/lyel.md) | COM NEW | $4.8m | 0.4% | 344,025 |  | Added +264,928 |
| [OPUS GENETICS INC (IRD)](/companies/ird.md) | COM | $4.6m | 0.4% | 1,125,000 |  | Added +5,000 |
| [4D MOLECULAR THERAPEUTICS IN (FDMT)](/companies/fdmt.md) | COM | $4.4m | 0.4% | 334,437 |  | Added +222,146 |
| [INTELLIA THERAPEUTICS INC (NTLA)](/companies/ntla.md) | COM | $4.2m | 0.4% | 250,000 |  | Added +5,000 |
| [VOYAGER THERAPEUTICS INC (VYGR)](/companies/vygr.md) | COM | $4.1m | 0.4% | 1,185,000 |  | Added +35,000 |
| [BIODESIX INC (BDSX)](/companies/bdsx.md) | COM | $4.1m | 0.4% | 180,000 |  | Reduced −58,047 |
| [ROCKET PHARMACEUTICALS INC (RCKT)](/companies/rckt.md) | COM | $3.4m | 0.3% | 1,000,000 |  | Added +45,000 |
| [JADE BIOSCIENCES INC (JBIO)](/companies/jbio.md) | COM NEW | $3.2m | 0.3% | 145,000 |  | Reduced −282,608 |
| [SANUWAVE HEALTH INC (SNWV)](/companies/snwv.md) | COM | $3.1m | 0.3% | 306,140 |  | Reduced −675,127 |
| [FORTRESS BIOTECH INC (FBIO)](/companies/fbio.md) | COM NEW | $2.7m | 0.2% | 890,000 |  | Reduced −152,000 |
| [JOURNEY MED CORP (DERM)](/companies/derm.md) | COM | $2.5m | 0.2% | 350,000 |  | Reduced −610,000 |
| [PHATHOM PHARMACEUTICALS INC (PHAT)](/companies/phat.md) | COM | $2.0m | 0.2% | 185,589 |  | New +185,589 |
| [INHIBRX BIOSCIENCES INC (INBX)](/companies/inbx.md) | COM | $1.9m | 0.2% | 20,291 |  | New +20,291 |
| [ENANTA PHARMACEUTICALS INC (ENTA)](/companies/enta.md) | COM | $1.8m | 0.2% | 125,000 |  | Unchanged |
| [HEMAB THERAPEUTICS HLDGS INC (COAG)](/companies/coag.md) | COM SHS | $1.8m | 0.2% | 47,652 |  | New +47,652 |
| [FIRST TRACKS BIOTHERAPEUTICS (TRAX)](/companies/trax.md) | ORD SHS | $1.3m | 0.1% | 65,000 |  | New +65,000 |
| [CG ONCOLOGY INC (CGON)](/companies/cgon.md) | COM | $1.3m | 0.1% | 17,789 |  | Reduced −77,011 |
| BIOHAVEN LTD | COM | $1.2m | 0.1% | 77,915 |  | New +77,915 |
| [ATEA PHARMACEUTICALS INC (AVIR)](/companies/avir.md) | COM | $1.1m | <0.1% | 235,000 |  | Reduced −87,600 |
| [PASITHEA THERAPEUTICS CORP (KTTA)](/companies/ktta.md) | COM NEW | $1.1m | <0.1% | 2,050,000 |  | New +2,050,000 |
| ADC THERAPEUTICS SA | SHS | $749.0k | <0.1% | 700,000 |  | New +700,000 |
| OKYO PHARMA LTD | SHS NEW | $562.8k | <0.1% | 375,204 |  | New +375,204 |
| [PALATIN TECHNOLOGIES INC (PTN)](/companies/ptn.md) | COM NEW | $221.2k | <0.1% | 20,500 |  | New +20,500 |
| [ADAGIO MED HLDGS INC (ADGM)](/companies/adgm.md) | COM | $13.4k | <0.1% | 18,444 |  | Unchanged |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| ASSERTIO HOLDINGS INC | COM NEW | $0 | 0.0% | 0 |  | Sold out −265,707 |
| [LB PHARMACEUTICALS INC (LBRX)](/companies/lbrx.md) | COM SHS | $0 | 0.0% | 0 |  | Sold out −14,506 |
| [NEXTCURE INC (NXTC)](/companies/nxtc.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −141,181 |
| [PERSPECTIVE THERAPEUTICS INC (CATX)](/companies/catx.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −4,675,000 |
| PERSPECTIVE THERAPEUTICS INC | CALL | $0 | 0.0% | 0 |  | Sold out −200,000 |
| [PROTALIX BIOTHERAPEUTICS INC (PLX)](/companies/plx.md) | COM | $0 | 0.0% | 0 |  | Sold out −340,000 |
| [RIGEL PHARMACEUTICALS INC (RIGL)](/companies/rigl.md) | COM | $0 | 0.0% | 0 |  | Sold out −70,000 |
| [SUTRO BIOPHARMA INC (STRO)](/companies/stro.md) | COM SHS | $0 | 0.0% | 0 |  | Sold out −190,671 |
| [TECTONIC THERAPEUTIC INC (TECX)](/companies/tecx.md) | COM | $0 | 0.0% | 0 |  | Sold out −123,000 |

Source: SEC EDGAR, Form 13F-HR, accession 0001420506-26-001803. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.