# 5AM Venture Management, LLC: Form 13F holdings

An institutional investment manager in SAN FRANCISCO, CA. SEC CIK 1799883.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $287.9m
- Positions: 16 (16 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1799883/000179988326000003/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [MAPLIGHT THERAPEUTICS INC (MPLT)](/companies/mplt.md) | COM | $34.0m | 11.8% | 950,011 |  | Unchanged |
| [TYRA BIOSCIENCES INC (TYRA)](/companies/tyra.md) | COM | $32.9m | 11.4% | 1,029,298 |  | Unchanged |
| [ENTRADA THERAPEUTICS INC (TRDA)](/companies/trda.md) | COM | $29.9m | 10.4% | 4,056,379 |  | Unchanged |
| PHARVARIS N V | COM | $27.6m | 9.6% | 797,600 |  | Unchanged |
| [CAMP4 THERAPEUTICS CORP (CAMP)](/companies/camp.md) | COM | $25.6m | 8.9% | 5,869,091 |  | Unchanged |
| [ARTIVA BIOTHERAPEUTICS INC (ARTV)](/companies/artv.md) | COM | $22.8m | 7.9% | 2,353,304 |  | Unchanged |
| [TECTONIC THERAPEUTIC INC (TECX)](/companies/tecx.md) | COM | $20.9m | 7.2% | 606,660 |  | Unchanged |
| [ZENTALIS PHARMACEUTICALS INC (ZNTL)](/companies/zntl.md) | COM | $19.1m | 6.7% | 3,947,913 |  | Unchanged |
| [CELLDEX THERAPEUTICS INC NEW (CLDX)](/companies/cldx.md) | COM NEW | $18.5m | 6.4% | 497,270 |  | Unchanged |
| [EYEPOINT INC (EYPT)](/companies/eypt.md) | COM NEW | $15.0m | 5.2% | 1,050,000 |  | Unchanged |
| BIOHAVEN LTD | COM | $11.0m | 3.8% | 738,972 |  | Unchanged |
| [SURROZEN INC (SRZN)](/companies/srzn.md) | COM NEW | $7.0m | 2.4% | 271,250 |  | Reduced −116,250 |
| SKYE BIOSCIENCE INC | COM NEW | $6.7m | 2.3% | 9,681,763 |  | Unchanged |
| [ALX ONCOLOGY HLDGS INC (ALXO)](/companies/alxo.md) | COM | $6.3m | 2.2% | 3,057,325 |  | Unchanged |
| [PROTARA THERAPEUTICS INC (TARA)](/companies/tara.md) | COM STK | $5.2m | 1.8% | 1,369,782 |  | Unchanged |
| [SILENCE THERAPEUTICS PLC (SLN)](/companies/sln.md) | ADS | $5.2m | 1.8% | 476,200 |  | Unchanged |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −580,945 |
| [ERASCA INC (ERAS)](/companies/eras.md) | COM | $0 | 0.0% | 0 |  | Sold out −3,485,971 |
| GH RESEARCH PLC | ORDINARY SHARES | $0 | 0.0% | 0 |  | Sold out −572,665 |
| [RALLYBIO CORP (RLYB)](/companies/rlyb.md) | COM | $0 | 0.0% | 0 |  | Sold out −291,788 |

Source: SEC EDGAR, Form 13F-HR, accession 0001799883-26-000003. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.