# Paradigm Biocapital Advisors LP: Form 13F holdings

An institutional investment manager in NEW YORK, NY. SEC CIK 1855655.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $5.34bn
- Positions: 28 (28 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1855655/000185565526000014/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [REVOLUTION MEDICINES INC (RVMD)](/companies/rvmd.md) | COM | $1.19bn | 22.3% | 6,361,323 |  | Reduced −294,380 |
| NUVALENT INC | COM | $731.7m | 13.7% | 5,924,433 |  | Added +600,000 |
| [EDGEWISE THERAPEUTICS INC (EWTX)](/companies/ewtx.md) | COM | $415.1m | 7.8% | 10,215,455 |  | Added +2,850,417 |
| [GENMAB A/S (GMAB)](/companies/gmab.md) | SPONSORED ADS | $360.8m | 6.8% | 13,133,131 |  | Added +5,165,295 |
| [SPYRE THERAPEUTICS INC (SYRE)](/companies/syre.md) | COM NEW | $341.0m | 6.4% | 3,840,778 |  | Added +1,883,512 |
| APOGEE THERAPEUTICS INC | COM | $209.2m | 3.9% | 1,576,385 |  | Added +228,142 |
| [ORUKA THERAPEUTICS INC (ORKA)](/companies/orka.md) | COM | $204.1m | 3.8% | 2,144,526 |  | Reduced −175,790 |
| [TANGO THERAPEUTICS INC (TNGX)](/companies/tngx.md) | COM | $198.7m | 3.7% | 6,357,523 |  | Added +2,347,844 |
| [BELITE BIO INC (BLTE)](/companies/blte.md) | SPONSORED ADS | $189.8m | 3.6% | 1,232,877 |  | Added +118,093 |
| [ERASCA INC (ERAS)](/companies/eras.md) | COM | $175.0m | 3.3% | 9,550,000 |  | Reduced −842,702 |
| [TARSUS PHARMACEUTICALS INC (TARS)](/companies/tars.md) | COM | $174.7m | 3.3% | 2,775,649 |  | Added +213,495 |
| [ALNYLAM PHARMACEUTICALS INC (ALNY)](/companies/alny.md) | COM | $144.5m | 2.7% | 480,000 |  | New +480,000 |
| [INSMED INC (INSM)](/companies/insm.md) | COM PAR $.01 | $141.4m | 2.6% | 1,325,977 |  | Added +71,489 |
| [MBX BIOSCIENCES INC (MBX)](/companies/mbx.md) | COM | $138.4m | 2.6% | 2,508,015 |  | New +2,508,015 |
| [VAXCYTE INC (PCVX)](/companies/pcvx.md) | COM | $123.7m | 2.3% | 2,127,852 |  | Reduced −2,665,168 |
| [VIRIDIAN THERAPEUTICS INC (VRDN)](/companies/vrdn.md) | COM | $123.5m | 2.3% | 6,723,788 |  | Added +3,574,895 |
| [OLEMA PHARMACEUTICALS INC (OLMA)](/companies/olma.md) | COM | $108.5m | 2.0% | 8,670,576 |  | Added +650,000 |
| [JADE BIOSCIENCES INC (JBIO)](/companies/jbio.md) | COM NEW | $63.5m | 1.2% | 2,857,405 |  | New +2,857,405 |
| [TYRA BIOSCIENCES INC (TYRA)](/companies/tyra.md) | COM | $58.4m | 1.1% | 1,828,607 |  | Reduced −226,384 |
| [ASSEMBLY BIOSCIENCES INC (ASMB)](/companies/asmb.md) | COM NEW | $42.7m | 0.8% | 1,553,748 |  | Added +888,497 |
| [EYEPOINT INC (EYPT)](/companies/eypt.md) | COM NEW | $41.3m | 0.8% | 2,890,397 |  | Reduced −252,040 |
| [ACHIEVE LIFE SCIENCE INC (ACHV)](/companies/achv.md) | COM | $32.3m | 0.6% | 4,951,856 |  | New +4,951,856 |
| [VOR BIOPHARMA INC (VOR)](/companies/vor.md) | COM NEW | $32.2m | 0.6% | 1,750,000 |  | Unchanged |
| [MAPLIGHT THERAPEUTICS INC (MPLT)](/companies/mplt.md) | COM | $24.6m | 0.5% | 685,852 |  | New +685,852 |
| [KARDIGAN INC (KARD)](/companies/kard.md) | COM | $21.5m | 0.4% | 900,000 |  | New +900,000 |
| [LEXEO THERAPEUTICS INC (LXEO)](/companies/lxeo.md) | COM | $19.4m | 0.4% | 4,175,382 |  | Reduced −2,008,752 |
| [EDITAS MEDICINE INC (EDIT)](/companies/edit.md) | COM | $18.1m | 0.3% | 5,586,625 |  | New +5,586,625 |
| [INVENTIVA SA (IVA)](/companies/iva.md) | ADS | $15.1m | 0.3% | 4,000,000 |  | Unchanged |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [ABIVAX SA (ABVX)](/companies/abvx.md) | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −772,473 |
| ARCELLX INC | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −5,774,016 |
| [BRIDGEBIO ONCOLOGY THERAPEUT (BBOT)](/companies/bbot.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −868,213 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −3,574,048 |
| [CYTOKINETICS INC (CYTK)](/companies/cytk.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −1,480,857 |
| [KALARIS THERAPEUTICS INC (KLRS)](/companies/klrs.md) | COM | $0 | 0.0% | 0 |  | Sold out −700,000 |
| [MAZE THERAPEUTICS INC (MAZE)](/companies/maze.md) | COM | $0 | 0.0% | 0 |  | Sold out −2,744,399 |
| [MIRUM PHARMACEUTICALS INC (MIRM)](/companies/mirm.md) | COM | $0 | 0.0% | 0 |  | Sold out −625,000 |
| [ORIC PHARMACEUTICALS INC (ORIC)](/companies/oric.md) | COM | $0 | 0.0% | 0 |  | Sold out −1,701,217 |
| [SCHOLAR ROCK HLDG CORP (SRRK)](/companies/srrk.md) | COM | $0 | 0.0% | 0 |  | Sold out −1,226,080 |
| [STRUCTURE THERAPEUTICS INC (GPCR)](/companies/gpcr.md) | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −545,287 |
| TERNS PHARMACEUTICALS INC | COM | $0 | 0.0% | 0 |  | Sold out −2,216,499 |
| UROGEN PHARMA LTD | COM | $0 | 0.0% | 0 |  | Sold out −1,703,949 |
| [VERADERMICS INC (MANE)](/companies/mane.md) | COMMON STOCK | $0 | 0.0% | 0 |  | Sold out −525,000 |

Source: SEC EDGAR, Form 13F-HR, accession 0001855655-26-000014. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.