# Frazier Life Sciences Management, L.P.: Form 13F holdings

An institutional investment manager in PALO ALTO, CA. SEC CIK 1892134.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $4.59bn
- Positions: 41 (41 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/1892134/000189213426000003/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [MIRUM PHARMACEUTICALS INC (MIRM)](/companies/mirm.md) | COM | $899.1m | 19.6% | 7,679,684 |  | Unchanged |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | $613.0m | 13.3% | 18,088,902 |  | Added +1,145,128 |
| [ERASCA INC (ERAS)](/companies/eras.md) | COM | $457.5m | 10.0% | 24,975,188 |  | Added +300,000 |
| [MBX BIOSCIENCES INC (MBX)](/companies/mbx.md) | COM | $367.2m | 8.0% | 6,652,013 |  | Unchanged |
| [ARCUTIS BIOTHERAPEUTICS INC (ARQT)](/companies/arqt.md) | COM | $258.9m | 5.6% | 9,874,511 |  | Unchanged |
| [TREVI THERAPEUTICS INC (TRVI)](/companies/trvi.md) | COM | $185.4m | 4.0% | 9,939,447 |  | Reduced −100 |
| [KRYSTAL BIOTECH INC (KRYS)](/companies/krys.md) | COM | $178.9m | 3.9% | 481,307 |  | Unchanged |
| [MAZE THERAPEUTICS INC (MAZE)](/companies/maze.md) | COM | $150.2m | 3.3% | 5,032,915 |  | Added +465,641 |
| [PHATHOM PHARMACEUTICALS INC (PHAT)](/companies/phat.md) | COM | $135.3m | 2.9% | 12,466,489 |  | Unchanged |
| [PALVELLA THERAPEUTICS INC NE (PVLA)](/companies/pvla.md) | COM | $134.8m | 2.9% | 882,400 |  | Unchanged |
| [BRIDGEBIO PHARMA INC (BBIO)](/companies/bbio.md) | COM | $115.3m | 2.5% | 1,548,139 |  | Reduced −1,900,000 |
| [DISC MEDICINE INC (IRON)](/companies/iron.md) | COM | $99.1m | 2.2% | 1,354,852 |  | Unchanged |
| [CYTOKINETICS INC (CYTK)](/companies/cytk.md) | COM NEW | $98.8m | 2.2% | 1,159,879 |  | Unchanged |
| [DYNE THERAPEUTICS INC (DYN)](/companies/dyn.md) | COM | $70.0m | 1.5% | 3,153,082 |  | Unchanged |
| ASCENDIS PHARMA A/S | SPONSORED ADR | $60.1m | 1.3% | 225,155 |  | Added +91,822 |
| [SAVARA INC (SVRA)](/companies/svra.md) | COM | $59.9m | 1.3% | 9,720,852 |  | Unchanged |
| [PARABILIS MEDICINES INC (PBLS)](/companies/pbls.md) | COM | $52.6m | 1.1% | 1,920,805 |  | New +1,920,805 |
| [AURA BIOSCIENCES INC (AURA)](/companies/aura.md) | COM | $50.4m | 1.1% | 7,100,000 |  | Added +2,000,000 |
| [ACHIEVE LIFE SCIENCE INC (ACHV)](/companies/achv.md) | COM | $49.7m | 1.1% | 7,614,836 |  | New +7,614,836 |
| [VOR BIOPHARMA INC (VOR)](/companies/vor.md) | COM NEW | $46.8m | 1.0% | 2,543,939 |  | Unchanged |
| [ALLOGENE THERAPEUTICS INC (ALLO)](/companies/allo.md) | COM | $46.7m | 1.0% | 22,446,668 |  | Added +18,650,000 |
| [TARSUS PHARMACEUTICALS INC (TARS)](/companies/tars.md) | COM | $45.9m | 1.0% | 728,644 |  | Unchanged |
| [BIOCRYST PHARMACEUTICALS INC (BCRX)](/companies/bcrx.md) | COM | $40.1m | 0.9% | 4,009,240 |  | Unchanged |
| ALKERMES PLC | SHS | $36.7m | 0.8% | 700,647 |  | Unchanged |
| [ACADIA PHARMACEUTICALS INC (ACAD)](/companies/acad.md) | COM | $36.4m | 0.8% | 1,438,198 |  | Unchanged |
| [ZAI LAB LTD (ZLAB)](/companies/zlab.md) | ADR | $36.1m | 0.8% | 1,902,320 |  | Unchanged |
| [MANNKIND CORP (MNKD)](/companies/mnkd.md) | COM NEW | $28.1m | 0.6% | 6,600,000 |  | Added +700,000 |
| [DESIGN THERAPEUTICS INC (DSGN)](/companies/dsgn.md) | COM | $26.2m | 0.6% | 1,809,854 |  | New +1,809,854 |
| [ACLARIS THERAPEUTICS INC (ACRS)](/companies/acrs.md) | COM | $26.1m | 0.6% | 4,925,374 |  | Unchanged |
| [SHATTUCK LABS INC (STTK)](/companies/sttk.md) | COM | $26.0m | 0.6% | 3,750,000 |  | New +3,750,000 |
| [KAILERA THERAPEUTICS INC (KLRA)](/companies/klra.md) | COMMON STOCK | $24.2m | 0.5% | 1,100,000 |  | New +1,100,000 |
| [MONTE ROSA THERAPEUTICS INC (GLUE)](/companies/glue.md) | COM | $24.2m | 0.5% | 1,000,000 |  | Unchanged |
| [LEXEO THERAPEUTICS INC (LXEO)](/companies/lxeo.md) | COM | $22.5m | 0.5% | 4,824,725 |  | Added +400,000 |
| [RELAY THERAPEUTICS INC (RLAY)](/companies/rlay.md) | COM | $19.0m | 0.4% | 1,015,693 |  | New +1,015,693 |
| [EVOLUS INC (EOLS)](/companies/eols.md) | COM | $18.3m | 0.4% | 2,630,665 |  | Unchanged |
| [IMMUNOCORE HLDGS PLC (IMCR)](/companies/imcr.md) | ADS | $15.4m | 0.3% | 484,782 |  | Unchanged |
| [VALNEVA SE (VALN)](/companies/valn.md) | SPONSORED ADS | $12.0m | 0.3% | 2,291,666 |  | Unchanged |
| NEWAMSTERDAM PHARMA COMPANY | \*W EXP 99/99/999 | $10.7m | 0.2% | 500,333 |  | Unchanged |
| [AUTOLUS THERAPEUTICS LTD (AUTL)](/companies/autl.md) | SPON ADS | $7.1m | 0.2% | 4,447,910 |  | Unchanged |
| [XILIO THERAPEUTICS INC (XLO)](/companies/xlo.md) | COM | $4.0m | <0.1% | 422,505 |  | Unchanged |
| [IBIO INC (IBIO)](/companies/ibio.md) | COM NEW | $3.4m | <0.1% | 1,953,467 |  | Unchanged |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [AGIOS PHARMACEUTICALS INC (AGIO)](/companies/agio.md) | COM | $0 | 0.0% | 0 |  | Sold out −1,256,080 |
| KALVISTA PHARMACEUTICALS INC | COM | $0 | 0.0% | 0 |  | Sold out −4,961,108 |
| [REVOLUTION MEDICINES INC (RVMD)](/companies/rvmd.md) | COM | $0 | 0.0% | 0 |  | Sold out −675,686 |

Source: SEC EDGAR, Form 13F-HR, accession 0001892134-26-000003. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.