# Siren, L.L.C.: Form 13F holdings

An institutional investment manager in New York, NY. SEC CIK 2005245.

- Quarter ended: 2026-06-30
- Filed: 2026-08-13
- Reported value: $4.94bn
- Positions: 117 (119 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/2005245/000200524526000008/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [Scholar Rock Holding Corp (SRRK)](/companies/srrk.md) | COM | $526.6m | 10.7% | 9,575,013 |  | Reduced −1,250,000 |
| [Kymera Therapeutics Inc (KYMR)](/companies/kymr.md) | COM | $336.7m | 6.8% | 2,935,830 |  | Reduced −251,000 |
| [Erasca Inc (ERAS)](/companies/eras.md) | COM | $208.8m | 4.2% | 11,397,781 |  | Added +153,535 |
| [Veradermics Inc (MANE)](/companies/mane.md) | COMMON STOCK | $203.5m | 4.1% | 1,655,374 |  | Added +150,000 |
| [Tango Therapeutics Inc (TNGX)](/companies/tngx.md) | COM | $193.2m | 3.9% | 6,179,364 |  | Added +522,259 |
| [Revolution Medicines Inc (RVMD)](/companies/rvmd.md) | COM | $168.6m | 3.4% | 900,000 |  | Reduced −210,980 |
| [Bicara Therapeutics Inc (BCAX)](/companies/bcax.md) | COM | $166.4m | 3.4% | 5,602,970 |  | Reduced −200,000 |
| [Arrowhead Pharmaceuticals Inc (ARWR)](/companies/arwr.md) | COM | $139.8m | 2.8% | 1,715,476 |  | Added +100,000 |
| [BeOne Medicines AG (ONC)](/companies/onc.md) | SPONSORED ADS | $132.5m | 2.7% | 465,000 |  | Unchanged |
| [Edgewise Therapeutics Inc (EWTX)](/companies/ewtx.md) | COM | $129.4m | 2.6% | 3,184,629 |  | Reduced −1,245,634 |
| [Rhythm Pharmaceuticals Inc (RYTM)](/companies/rytm.md) | COM | $126.2m | 2.6% | 1,136,275 |  | Added +410,764 |
| [Lexicon Pharmaceuticals Inc (LXRX)](/companies/lxrx.md) | COM NEW | $106.3m | 2.2% | 44,303,518 |  | Unchanged |
| [Enliven Therapeutics Inc (ELVN)](/companies/elvn.md) | COM | $90.1m | 1.8% | 1,774,411 |  | Added +1,028,185 |
| [Spyre Therapeutics Inc (SYRE)](/companies/syre.md) | COM NEW | $86.0m | 1.7% | 968,598 |  | Added +150,000 |
| [Parabilis Medicines Inc (PBLS)](/companies/pbls.md) | COM | $81.9m | 1.7% | 2,992,259 |  | New +2,992,259 |
| [Xenon Pharmaceuticals Inc (XENE)](/companies/xene.md) | COM | $79.6m | 1.6% | 1,318,564 |  | Unchanged |
| [Solid Biosciences Inc (SLDB)](/companies/sldb.md) | COM NEW | $76.8m | 1.6% | 7,690,405 |  | Unchanged |
| [Abivax SA (ABVX)](/companies/abvx.md) | SPONSORED ADS | $76.8m | 1.6% | 576,000 |  | New +576,000 |
| [Hemab Therapeutics Holdings Inc (COAG)](/companies/coag.md) | COM SHS | $76.6m | 1.6% | 2,086,834 |  | New +2,086,834 |
| [Arcus Biosciences Inc (RCUS)](/companies/rcus.md) | COM | $74.6m | 1.5% | 2,420,430 |  | Reduced −586,647 |
| [Cogent Biosciences Inc (COGT)](/companies/cogt.md) | COM | $72.0m | 1.5% | 1,859,279 |  | Added +150,000 |
| [Relay Therapeutics Inc (RLAY)](/companies/rlay.md) | COM | $68.3m | 1.4% | 3,650,000 |  | New +3,650,000 |
| [Taysha Gene Therapies Inc (TSHA)](/companies/tsha.md) | COM SHS | $67.1m | 1.4% | 9,846,579 |  | Added +1,016,666 |
| [Definium Therapeutics Inc (DFTX)](/companies/dftx.md) | COM SHS | $66.8m | 1.4% | 1,419,493 |  | Added +500,000 |
| [Stoke Therapeutics Inc (STOK)](/companies/stok.md) | COM | $65.3m | 1.3% | 1,995,347 |  | Unchanged |
| [Disc Medicine Inc (IRON)](/companies/iron.md) | COM | $65.0m | 1.3% | 888,401 |  | Reduced −100,000 |
| [Cytokinetics Inc (CYTK)](/companies/cytk.md) | COM NEW | $64.7m | 1.3% | 758,952 |  | Added +145,000 |
| [Septerna Inc (SEPN)](/companies/sepn.md) | COM | $63.6m | 1.3% | 1,900,000 |  | Reduced −100,000 |
| [Olema Pharmaceuticals Inc (OLMA)](/companies/olma.md) | COM | $60.8m | 1.2% | 4,856,949 |  | Added +100,000 |
| Crinetics Pharmaceuticals Inc | COM | $53.2m | 1.1% | 1,420,788 |  | Reduced −482,848 |
| [Kailera Therapeutics Inc (KLRA)](/companies/klra.md) | COMMON STOCK | $48.8m | 1.0% | 2,214,286 |  | New +2,214,286 |
| [Dyne Therapeutics, Inc (DYN)](/companies/dyn.md) | COM | $47.3m | 1.0% | 2,129,125 |  | Reduced −100,000 |
| [Structure Therapeutics Inc (GPCR)](/companies/gpcr.md) | SPONSORED ADS | $46.9m | 0.9% | 872,967 |  | Reduced −455,731 |
| Taboola.com Ltd | ORD SHS | $42.1m | 0.9% | 8,423,410 |  | Reduced −1,546,085 |
| [Palvella Therapeutics Inc (PVLA)](/companies/pvla.md) | COM | $39.3m | 0.8% | 257,485 |  | Unchanged |
| [Silence Therapeutics PLC (SLN)](/companies/sln.md) | ADS | $36.4m | 0.7% | 3,311,438 |  | Added +400,000 |
| [Denali Therapeutics Inc (DNLI)](/companies/dnli.md) | COM | $35.9m | 0.7% | 1,396,513 |  | Unchanged |
| [Remitly Global Inc (RELY)](/companies/rely.md) | COM | $34.6m | 0.7% | 1,543,271 |  | Unchanged |
| [Cullinan Therapeutics Inc (CGEM)](/companies/cgem.md) | COM | $34.5m | 0.7% | 1,893,410 |  | Added +700,000 |
| [Capital One Finl Corp (COF)](/companies/cof.md) | COM | $34.4m | 0.7% | 171,615 |  | New +171,615 |
| [Trevi Therapeutics Inc (TRVI)](/companies/trvi.md) | COM | $33.3m | 0.7% | 1,786,867 |  | Unchanged |
| [Oric Pharmaceuticals Inc (ORIC)](/companies/oric.md) | COM | $32.5m | 0.7% | 2,998,192 |  | Unchanged |
| [Alphabet Inc (GOOGL)](/companies/googl.md) | CAP STK CL A | $32.2m | 0.7% | 90,000 |  | Added +24,297 |
| [Dbv Technologies SA (DBVT)](/companies/dbvt.md) | SPONSORED ADS | $30.5m | 0.6% | 1,857,362 |  | Unchanged |
| [Absci Corp (ABSI)](/companies/absi.md) | COM | $28.7m | 0.6% | 2,474,764 |  | Added +674,764 |
| [Sionna Therapeutics Inc (SION)](/companies/sion.md) | COM | $26.9m | 0.5% | 610,515 |  | Added +310,515 |
| [Rapport Therapeutics Inc (RAPP)](/companies/rapp.md) | COM | $26.7m | 0.5% | 641,469 |  | Unchanged |
| [Amylyx Pharmaceuticals Inc (AMLX)](/companies/amlx.md) | COM | $26.6m | 0.5% | 1,480,586 |  | Added +250,586 |
| [Annexon Inc (ANNX)](/companies/annx.md) | COM | $25.5m | 0.5% | 4,458,646 |  | Added +500,000 |
| [Monopar Therapeutics Inc (MNPR)](/companies/mnpr.md) | COM NEW | $25.0m | 0.5% | 270,118 |  | Unchanged |
| [Oruka Therapeutics Inc (ORKA)](/companies/orka.md) | COM | $23.8m | 0.5% | 250,000 |  | New +250,000 |
| [Seaport Therapeutics Inc (SPTX)](/companies/sptx.md) | COMMON STOCK | $23.8m | 0.5% | 1,095,316 |  | New +1,095,316 |
| Damora Therapeutics Inc | COM NEW | $23.4m | 0.5% | 900,000 |  | Unchanged |
| [Tyra Biosciences Inc (TYRA)](/companies/tyra.md) | COM | $23.2m | 0.5% | 725,000 |  | New +725,000 |
| Zura Bio Ltd | CLASS A ORD SHS | $22.0m | 0.4% | 3,734,866 |  | Unchanged |
| [Taiwan Semiconductor Manufacturing Co Ltd (TSM)](/companies/tsm.md) | SPONSORED ADS | $21.3m | 0.4% | 44,700 |  | Added +2,500 |
| [NVIDIA Corp (NVDA)](/companies/nvda.md) | COM | $19.0m | 0.4% | 95,000 |  | Added +5,915 |
| [Rezolute Inc (RZLT)](/companies/rzlt.md) | COM NEW | $17.3m | 0.4% | 3,328,287 |  | Unchanged |
| [MapLight Therapeutics Inc (MPLT)](/companies/mplt.md) | COM | $16.1m | 0.3% | 450,000 |  | Unchanged |
| [Neumora Therapeutics Inc (NMRA)](/companies/nmra.md) | COM | $14.4m | 0.3% | 8,497,822 |  | Unchanged |
| Nebius Group NV | SHS CLASS A | $14.4m | 0.3% | 52,000 |  | Reduced −61,614 |
| [Microsoft Corp (MSFT)](/companies/msft.md) | COM | $14.0m | 0.3% | 37,500 |  | Reduced −3,880 |
| [CytomX Therapeutics Inc (CTMX)](/companies/ctmx.md) | COM | $13.0m | 0.3% | 3,457,711 |  | Unchanged |
| [Generate Biomedicines Inc (GENB)](/companies/genb.md) | COM SHS | $12.4m | 0.3% | 736,104 |  | Unchanged |
| [Inhibikase Therapeutics Inc (IKT)](/companies/ikt.md) | COM NEW | $11.9m | 0.2% | 5,850,000 |  | Unchanged |
| [Adagene Inc (ADAG)](/companies/adag.md) | ADS | $11.2m | 0.2% | 2,666,666 |  | New +2,666,666 |
| [enGene Therapeutics Inc (ENGN)](/companies/engn.md) | COM | $10.8m | 0.2% | 6,256,662 |  | New +6,256,662 |
| [Whitehawk Therapeutics Inc (WHWK)](/companies/whwk.md) | COM | $10.7m | 0.2% | 2,337,102 |  | Added +255,102 |
| [Datadog Inc (DDOG)](/companies/ddog.md) | CL A COM | $10.4m | 0.2% | 40,000 |  | Reduced −14,300 |
| [ServiceNow Inc (NOW)](/companies/now.md) | COM | $9.9m | 0.2% | 100,000 |  | Added +12,910 |
| [Broadcom Inc (AVGO)](/companies/avgo.md) | COM | $9.4m | 0.2% | 25,000 |  | Added +10,000 |
| [IONQ Inc (IONQ)](/companies/ionq.md) | COM | $9.1m | 0.2% | 170,000 |  | Unchanged |
| [Microsoft Corp (MSFT)](/companies/msft.md) | COM | $9.0m | 0.2% | 24,000 | Call | New +24,000 |
| Jfrog Ltd | ORD SHS | $8.7m | 0.2% | 95,500 |  | Reduced −33,316 |
| Oculis Holding AG | ORDINARY SHARES | $8.7m | 0.2% | 625,000 |  | New +625,000 |
| IREN Ltd | ORDINARY SHARES | $8.0m | 0.2% | 175,000 |  | Added +131,900 |
| [Amazon.com Inc (AMZN)](/companies/amzn.md) | COM | $7.7m | 0.2% | 32,500 |  | Reduced −14,141 |
| [CrowdStrike Holdings Inc (CRWD)](/companies/crwd.md) | CL A | $7.6m | 0.2% | 10,000 |  | Reduced −13,070 |
| [Design Therapeutics Inc (DSGN)](/companies/dsgn.md) | COM | $7.6m | 0.2% | 523,212 |  | New +523,212 |
| [PDD Holdings Inc (PDD)](/companies/pdd.md) | SPONSORED ADS | $7.2m | 0.1% | 95,000 |  | Added +11,599 |
| [Satellos Bioscience Inc (MSLE)](/companies/msle.md) | COM | $6.9m | 0.1% | 892,074 |  | Unchanged |
| [Dynatrace, Inc (DT)](/companies/dt.md) | COM NEW | $6.8m | 0.1% | 155,000 |  | Added +5,000 |
| [Apple Inc (AAPL)](/companies/aapl.md) | COM | $6.7m | 0.1% | 23,000 | Call | New +23,000 |
| [Tenax Therapeutics Inc (TENX)](/companies/tenx.md) | COM NEW | $6.2m | 0.1% | 427,141 |  | Unchanged |
| [vTv Therapeutics Inc (VTVT)](/companies/vtvt.md) | CL A NEW | $6.1m | 0.1% | 163,000 |  | Unchanged |
| [Eloxx Pharmaceuticals Inc (ELOX)](/companies/elox.md) | COM NEW | $5.6m | 0.1% | 400,000 |  | New +400,000 |
| [Agomab Therapeutics NV (AGMB)](/companies/agmb.md) | SPONSORED ADS | $5.3m | 0.1% | 411,250 |  | Unchanged |
| [Alibaba Group Holding Ltd (BABA)](/companies/baba.md) | SPONSORED ADS | $4.8m | <0.1% | 50,000 |  | New +50,000 |
| [Korro Bio Inc (KRRO)](/companies/krro.md) | COM | $4.6m | <0.1% | 347,718 |  | Unchanged |
| Cellebrite DI Ltd | ORDINARY SHARES | $4.5m | <0.1% | 311,544 |  | Unchanged |
| [Invivyd Inc (IVVD)](/companies/ivvd.md) | COM | $4.4m | <0.1% | 5,000,000 |  | Added +1,000,000 |
| [Ouster Inc (OUST)](/companies/oust.md) | COM NEW | $4.2m | <0.1% | 67,500 |  | New +67,500 |
| [Palisade Bio Inc (PALI)](/companies/pali.md) | COM | $4.2m | <0.1% | 2,000,000 |  | New +2,000,000 |
| [Aeva Technologies Inc (AEVA)](/companies/aeva.md) | COM NEW | $4.2m | <0.1% | 145,459 |  | Added +35,459 |
| [Seer Inc (SEER)](/companies/seer.md) | COM CL A | $4.1m | <0.1% | 2,458,673 |  | Unchanged |
| [NovaBridge Biosciences (NBP)](/companies/nbp.md) | SPONSORED ADS | $3.9m | <0.1% | 2,004,739 |  | Reduced −995,261 |
| [GitLab Inc (GTLB)](/companies/gtlb.md) | CLASS A COM | $3.8m | <0.1% | 125,000 |  | Added +25,000 |
| [Odyssey Therapeutics Inc (ODTX)](/companies/odtx.md) | COMMON STOCK | $3.7m | <0.1% | 200,000 |  | New +200,000 |
| [Foghorn Therapeutics Inc (FHTX)](/companies/fhtx.md) | COM | $3.5m | <0.1% | 720,720 |  | Unchanged |
| [Agenus Inc (AGEN)](/companies/agen.md) | COM NEW | $3.3m | <0.1% | 1,064,250 |  | Unchanged |
| monday.com Ltd | SHS | $3.1m | <0.1% | 42,500 |  | Added +17,500 |
| [Zoetis Inc (ZTS)](/companies/zts.md) | CL A | $2.5m | <0.1% | 35,000 |  | New +35,000 |
| [Workiva Inc (WK)](/companies/wk.md) | COM CL A | $2.2m | <0.1% | 45,000 |  | Reduced −47,500 |
| [Netflix Inc (NFLX)](/companies/nflx.md) | COM | $1.8m | <0.1% | 25,000 |  | New +25,000 |
| [Kalaris Therapeutics Inc (KLRS)](/companies/klrs.md) | COM | $1.8m | <0.1% | 435,798 |  | Unchanged |
| [Quantinuum Inc (QNT)](/companies/qnt.md) | CL A COM | $1.6m | <0.1% | 20,000 |  | New +20,000 |
| [Rani Therapeutics Holdings Inc (RANI)](/companies/rani.md) | COM CL A | $1.5m | <0.1% | 2,000,000 |  | Unchanged |
| [Tesla Inc (TSLA)](/companies/tsla.md) | COM | $1.5m | <0.1% | 3,500 |  | Reduced −18,000 |
| [KE Holdings Inc (BEKE)](/companies/beke.md) | SPONSORED ADS | $1.5m | <0.1% | 100,000 |  | Unchanged |
| Entera Bio Ltd | SHS | $1.3m | <0.1% | 736,457 |  | New +736,457 |
| [Medline Inc (MDLN)](/companies/mdln.md) | COM CL A | $986.0k | <0.1% | 25,000 |  | Unchanged |
| [Lumentum Holdings Inc (LITE)](/companies/lite.md) | COM | $905.3k | <0.1% | 1,055 |  | New +1,055 |
| [Figma Inc (FIG)](/companies/fig.md) | CLASS A COM STK | $904.5k | <0.1% | 50,000 |  | Unchanged |
| Gossamer Bio Inc | COM | $857.4k | <0.1% | 5,208,968 |  | Unchanged |
| [Fox Corp (FOXA)](/companies/foxa.md) | CL A COM | $521.6k | <0.1% | 10,000 |  | New +10,000 |
| [AT&T Inc (T)](/companies/t.md) | COM | $517.5k | <0.1% | 25,000 |  | New +25,000 |
| Nu Holdings Ltd. | ORD SHS CL A | $334.0k | <0.1% | 25,000 |  | Unchanged |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| Amer Sports Inc | COM SHS | $0 | 0.0% | 0 |  | Sold out −50,000 |
| [Bicycle Therapeutics PLC (BCYC)](/companies/bcyc.md) | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −1,560,882 |
| Centessa Pharmaceuticals PLC | SPONSORED ADS | $0 | 0.0% | 0 |  | Sold out −1,053,464 |
| enGene Holdings Inc | COM | $0 | 0.0% | 0 |  | Sold out −5,253,159 |
| [Forgent Power Solutions, Inc (FPS)](/companies/fps.md) | COM SHS CL A | $0 | 0.0% | 0 |  | Sold out −100,000 |
| [Fulcrum Therapeutics Inc (FULC)](/companies/fulc.md) | COM | $0 | 0.0% | 0 |  | Sold out −2,350,000 |
| [Micron Technology Inc (MU)](/companies/mu.md) | COM | $0 | 0.0% | 0 |  | Sold out −6,000 |
| [Primo Brands Corp (PRMB)](/companies/prmb.md) | CLASS A COM SHS | $0 | 0.0% | 0 |  | Sold out −50,000 |
| Uniqure NV | SHS | $0 | 0.0% | 0 |  | Sold out −1,000,000 |
| WAVE Life Sciences Ltd | SHS | $0 | 0.0% | 0 |  | Sold out −2,450,000 |

Source: SEC EDGAR, Form 13F-HR, accession 0002005245-26-000008. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.