# Ishara Investments LP: Form 13F holdings

An institutional investment manager in LOS ANGELES, CA. SEC CIK 2111609.

- Quarter ended: 2026-06-30
- Filed: 2026-08-14
- Reported value: $136.1m
- Positions: 41 (41 lines in the filing's table; lines for the same security and option type are added together here)
- Compared with: the 13F for the quarter ended 2026-03-31
- Filing: https://www.sec.gov/Archives/edgar/data/2111609/000211160926000004/

## Holdings

As filed, largest first. Reported value is what the manager stated at the quarter end (Jun 30, 2026), in US dollars; it is filing data, not a price. Weight is the share of the total reported value.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| [ACADIA PHARMACEUTICALS INC (ACAD)](/companies/acad.md) | COM | $10.4m | 7.6% | 410,000 |  | Added +287,000 |
| [XERIS BIOPHARMA HOLDINGS INC (XERS)](/companies/xers.md) | COM | $9.7m | 7.2% | 1,230,000 |  | Added +205,000 |
| [BIOMARIN PHARMACEUTICAL INC (BMRN)](/companies/bmrn.md) | COM | $8.2m | 6.0% | 143,500 |  | Added +61,500 |
| [PRAXIS PRECISION MEDICINES I (PRAX)](/companies/prax.md) | COM NEW | $7.5m | 5.5% | 22,550 |  | Unchanged |
| [ULTRAGENYX PHARMACEUTICAL IN (RARE)](/companies/rare.md) | COM | $6.8m | 5.0% | 205,000 |  | Added +30,750 |
| [AGIOS PHARMACEUTICALS INC (AGIO)](/companies/agio.md) | COM | $6.1m | 4.5% | 164,000 |  | New +164,000 |
| [INSMED INC (INSM)](/companies/insm.md) | COM PAR $.01 | $5.5m | 4.0% | 51,250 |  | New +51,250 |
| CRINETICS PHARMACEUTICALS IN | COM | $5.4m | 3.9% | 143,500 |  | New +143,500 |
| [ZENTALIS PHARMACEUTICALS INC (ZNTL)](/companies/zntl.md) | COM | $5.0m | 3.7% | 1,025,000 |  | Reduced −205,000 |
| [VAXCYTE INC (PCVX)](/companies/pcvx.md) | COM | $4.8m | 3.5% | 82,000 |  | Added +24,600 |
| [ANNEXON INC (ANNX)](/companies/annx.md) | COM | $4.7m | 3.4% | 820,000 |  | Added +645,750 |
| [TRAVERE THERAPEUTICS INC (TVTX)](/companies/tvtx.md) | COM | $4.7m | 3.4% | 82,000 |  | Reduced −28,700 |
| [TONIX PHARMACEUTICALS HLDG C (TNXP)](/companies/tnxp.md) | COM NEW | $4.3m | 3.2% | 338,250 |  | New +338,250 |
| [BRIDGEBIO PHARMA INC (BBIO)](/companies/bbio.md) | COM | $4.3m | 3.1% | 57,400 |  | New +57,400 |
| [AXSOME THERAPEUTICS INC. (AXSM)](/companies/axsm.md) | COM | $4.0m | 2.9% | 16,400 |  | Reduced −24,600 |
| [CONTINEUM THERAPEUTICS INC (CTNM)](/companies/ctnm.md) | CL A | $3.4m | 2.5% | 205,000 |  | Added +63,000 |
| [LEXICON PHARMACEUTICALS INC (LXRX)](/companies/lxrx.md) | COM NEW | $3.1m | 2.2% | 1,271,000 |  | Added +369,000 |
| [KURA ONCOLOGY INC (KURA)](/companies/kura.md) | COM | $3.0m | 2.2% | 276,750 |  | New +276,750 |
| [DBV TECHNOLOGIES S A (DBVT)](/companies/dbvt.md) | SPONSORED ADS | $3.0m | 2.2% | 184,500 |  | Added +82,000 |
| [GENMAB A/S (GMAB)](/companies/gmab.md) | SPONSORED ADS | $2.8m | 2.1% | 102,500 |  | Added +20,500 |
| [CYTOKINETICS INC (CYTK)](/companies/cytk.md) | COM NEW | $2.8m | 2.1% | 32,800 |  | New +32,800 |
| [MINERALYS THERAPEUTICS INC (MLYS)](/companies/mlys.md) | COM | $2.8m | 2.0% | 102,500 |  | Added +20,500 |
| [SILENCE THERAPEUTICS PLC (SLN)](/companies/sln.md) | ADS | $2.4m | 1.8% | 55,350 |  | Reduced −85,150 |
| [NUVATION BIO INC (NUVB)](/companies/nuvb.md) | COM CL A | $2.1m | 1.5% | 369,000 |  | New +369,000 |
| WAVE LIFE SCIENCES LTD | SHS | $1.9m | 1.4% | 328,000 |  | New +328,000 |
| [NEKTAR THERAPEUTICS (NKTR)](/companies/nktr.md) | COM NEW | $1.9m | 1.4% | 26,650 |  | New +26,650 |
| [SCHOLAR ROCK HLDG CORP (SRRK)](/companies/srrk.md) | COM | $1.7m | 1.2% | 30,750 |  | Reduced −26,650 |
| [ENLIVEN THERAPEUTICS INC (ELVN)](/companies/elvn.md) | COM | $1.7m | 1.2% | 32,800 |  | New +32,800 |
| [ALNYLAM PHARMACEUTICALS INC (ALNY)](/companies/alny.md) | COM | $1.5m | 1.1% | 5,125 |  | Unchanged |
| [BEAM THERAPEUTICS INC (BEAM)](/companies/beam.md) | COM | $1.4m | 1.0% | 41,000 |  | Reduced −16,400 |
| [SIONNA THERAPEUTICS INC (SION)](/companies/sion.md) | COM | $1.4m | 1.0% | 123,000 |  | Added +73,800 |
| [ORIC PHARMACEUTICALS INC (ORIC)](/companies/oric.md) | COM | $1.3m | 1.0% | 123,000 |  | Added +20,500 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | $1.3m | 0.9% | 36,900 |  | Unchanged |
| [VERTEX PHARMACEUTICALS INC (VRTX)](/companies/vrtx.md) | COM | $1.2m | 0.9% | 2,460 |  | New +2,460 |
| [ARS PHARMACEUTICALS INC (SPRY)](/companies/spry.md) | COM | $1.1m | 0.8% | 143,490 |  | New +143,490 |
| [MONOPAR THERAPEUTICS INC (MNPR)](/companies/mnpr.md) | COM NEW | $1.1m | 0.8% | 12,300 |  | New +12,300 |
| [ERASCA INC (ERAS)](/companies/eras.md) | COM | $751.1k | 0.6% | 41,000 |  | New +41,000 |
| [VERA THERAPEUTICS INC (VERA)](/companies/vera.md) | CL A | $439.8k | 0.3% | 10,250 |  | Reduced −71,750 |
| IMMATICS N.V | SHS | $311.5k | 0.2% | 30,750 |  | Reduced −123,000 |
| [MEREO BIOPHARMA GROUP PLC (MREO)](/companies/mreo.md) | SPON ADS | $244.2k | 0.2% | 768,750 |  | New +768,750 |
| GOSSAMER BIO INC | COM | $135.0k | <0.1% | 820,000 |  | Unchanged |

## Sold out

Held at the end of the quarter before and not reported this quarter.

| Issuer | Class | Reported value | Weight | Shares | Put or call | Change on the quarter before |
| --- | --- | ---: | ---: | ---: | --- | --- |
| AMICUS THERAPEUTIC | COM | $0 | 0.0% | 0 |  | Sold out −369,000 |
| [ARDELYX INC (ARDX)](/companies/ardx.md) | COM | $0 | 0.0% | 0 |  | Sold out −451,000 |
| [ARROWHEAD PHARMACEUTICALS IN (ARWR)](/companies/arwr.md) | COM | $0 | 0.0% | 0 |  | Sold out −55,350 |
| CATALYST PHARMACEUTICALS INC | COM | $0 | 0.0% | 0 |  | Sold out −82,000 |
| [EDGEWISE THERAPEUTICS INC (EWTX)](/companies/ewtx.md) | COM | $0 | 0.0% | 0 |  | Sold out −49,200 |
| [IDEAYA BIOSCIENCES INC (IDYA)](/companies/idya.md) | COM | $0 | 0.0% | 0 |  | Sold out −24,600 |
| KALVISTA PHARMACEUTICALS INC | COM | $0 | 0.0% | 0 |  | Sold out −276,750 |
| [LIGAND PHARMACEUTICALS INC (LGND)](/companies/lgnd.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −8,200 |
| [MOONLAKE IMMUNOTHERAPEUTICS (MLTX)](/companies/mltx.md) | CLASS A ORD | $0 | 0.0% | 0 |  | Sold out −174,250 |
| [PRAXIS PRECISION MEDICINES I (PRAX)](/companies/prax.md) | COM NEW | $0 | 0.0% | 0 | Put | Sold out −20,500 |
| [PTC THERAPEUTICS INC (PTCT)](/companies/ptct.md) | COM | $0 | 0.0% | 0 |  | Sold out −10,250 |
| [VERASTEM INC (VSTM)](/companies/vstm.md) | COM NEW | $0 | 0.0% | 0 |  | Sold out −820,000 |

Source: SEC EDGAR, Form 13F-HR, accession 0002111609-26-000004. Last ingested by Listed: Oct 22, 2026, 05:26 ET. No prices; not investment advice.