PERCEPTIVE ADVISORS LLC

Name: PERCEPTIVE ADVISORS LLC: Form 13F holdings for the quarter ended 2026-06-30
Creator: Listed

An institutional investment manager in NEW YORK, NY. Its Form 13F for the quarter ended Jun 30, 2026, filed Aug 14, 2026. SEC CIK 1224962.

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Reported value$6.66bn
Positions109

Holdings: 109 positions

The filing on sec.gov

As filed, largest first. Reported value is what the manager stated for each position at the quarter end, in US dollars; it is filing data, not a price. Weight is the position's share of the total reported value. Changes compare with the 13F for the quarter ended 2026-03-31.

PERCEPTIVE ADVISORS LLC, holdings
Issuer	Class	CUSIP	Reported value$m	Weight	Shares	Put or call	Change on the quarter before
Praxis Precision Medicines IPRAX	COM NEW	74006W207	682	10.2%	2,035,986		Unchanged
Spyre Therapeutics IncSYRE	COM NEW	00773J202	383	5.8%	4,319,496		Added+536,271
Celcuity IncCELC	COM	15102K100	334	5.0%	3,197,200		Added+70,000
Ascendis Pharma A/S	ORD SHS	K08588103	310	4.7%	1,163,721		New+1,163,721
Rhythm Pharmaceuticals IncRYTM	COM	76243J105	287	4.3%	2,586,295		Added+212,500
Roivant Sciences Ltd	SHS	G76279101	286	4.3%	8,085,461		Reduced−200,000
Relay Therapeutics IncRLAY	COM	75943R102	264	4.0%	14,106,187		Added+4,355,046
Travere Therapeutics IncTVTX	COM	89422G107	213	3.2%	3,752,574		Reduced−389,977
Kardigan IncKARD	COM	485925101	196	2.9%	8,200,662		New+8,200,662
Nuvalent Inc	COM	670703107	195	2.9%	1,580,505		Unchanged
Edgewise Therapeutics IncEWTX	COM	28036F105	178	2.7%	4,373,974		Reduced−50,000
Apogee Therapeutics Inc	COM	03770N101	174	2.6%	1,308,113		Reduced−232,271
Amylyx Pharmaceuticals IncAMLX	COM	03237H101	150	2.2%	8,334,882		Added+50,000
Meiragtx Holdings plc	COM	G59665102	146	2.2%	10,786,658		Added+460,555
Oruka Therapeutics IncORKA	COM	687604108	128	1.9%	1,345,063		Reduced−50,438
Inhibrx Biosciences IncINBX	COM	45720N103	123	1.8%	1,297,763		Reduced−144,944
Protagonist Therapeutics IncPTGX	COM	74366E102	120	1.8%	981,879		Reduced−249,000
Solid Biosciences IncSLDB	COM NEW	83422E204	119	1.8%	11,906,646		Unchanged
Zymeworks IncZYME	COM	98985Y108	109	1.6%	4,182,953		Added+672,875
Tango Therapeutics IncTNGX	COM	87583X109	106	1.6%	3,377,000		Added+2,568,847
Immatics N.V	SHS	N44445109	105	1.6%	10,383,456		Unchanged
Nurix Therapeutics IncNRIX	COM	67080M103	105	1.6%	4,320,422		Added+609,545
Biocryst Pharmaceuticals IncBCRX	COM	09058V103	103	1.5%	10,308,888		Added+2,874,855
Revolution Medicines IncRVMD	COM	76155X100	98.8	1.5%	527,600		Added+269,000
Avalyn Pharmaceuticals IncAVLN	COM SHS	05348Y105	88.1	1.3%	2,675,296		New+2,675,296
Moderna IncMRNA	COM	60770K107	70.0	1.1%	1,000,000	Put	Unchanged
Dyne Therapeutics IncDYN	COM	26818M108	59.7	0.9%	2,689,235		Reduced−1,979,604
Biogen IncBIIB	COM	09062X103	59.7	0.9%	276,173		New+276,173
Immunovant IncIMVT	COM	45258J102	52.3	0.8%	1,357,383		Reduced−240,000
Unitedhealth Group IncUNH	COM	91324P102	48.5	0.7%	116,806		New+116,806
SPDR Series Trust	ST STR SP BIOT	78464A870	47.5	0.7%	300,000	Put	New+300,000
Ionis Pharmaceuticals IncIONS	COM	462222100	44.9	0.7%	566,000		Added+62,000
Sutro Biopharma IncSTRO	COM SHS	869367201	43.3	0.7%	1,304,846		Added+589,539
Alto Neuroscience IncANRO	COM SHS	02157Q109	42.5	0.6%	1,609,893		Reduced−400,000
Jazz Pharmaceuticals plc	SHS USD	G50871105	41.0	0.6%	170,000		Unchanged
Corvus Pharmaceuticals IncCRVS	COM	221015100	39.9	0.6%	2,667,441		Added+375,000
Sionna Therapeutics IncSION	COM	829401108	39.8	0.6%	905,000		Added+246,561
Cytomx Therapeutics Inc.CTMX	COM	23284F105	39.1	0.6%	10,439,185		Added+340,361
Artivion IncAORT	COM	228903100	39.0	0.6%	1,737,290		Added+100,000
X4 Pharmaceuticals IncXFOR	COM NEW	98420X202	37.0	0.6%	7,933,491		Added+1,195,843
Corcept Therapeutics IncCORT	COM	218352102	34.6	0.5%	398,385		Added+348,385
Repligen CorpRGEN	COM	759916109	33.9	0.5%	248,212		Reduced−32,329
Anteris Technologies GlobalAVR	COM	03675P102	33.7	0.5%	3,425,476		Unchanged
Rapport Therapeutics IncRAPP	COM	75383L102	32.2	0.5%	773,342		Added+99,419
Damora Therapeutics Inc	COM NEW	36322Q206	31.8	0.5%	1,223,000		Unchanged
Charles Riv Labs International IncCRL	COM	159864107	31.8	0.5%	140,000		New+140,000
Axsome Therapeutics Inc.AXSM	COM	05464T104	29.0	0.4%	118,450		Reduced−31,500
Eyepoint IncEYPT	COM NEW	30233G209	28.6	0.4%	2,000,000	Put	New+2,000,000
DBV Technologies S aDBVT	SPONSORED ADS	23306J309	27.1	0.4%	1,653,350		Added+688,959
Irhythm Holdings IncIRTC	COM	450056106	26.6	0.4%	223,766		Added+118,740
Adaptive Biotechnologies CorADPT	COM	00650F109	26.1	0.4%	1,217,325		Added+1,064,825
SAB Biotherapeutics IncSABS	COM NEW	78397T202	25.8	0.4%	6,627,501		Added+195,758
Danaher Corp DelDHR	COM	235851102	24.8	0.4%	130,000		New+130,000
Tenax Therapeutics IncTENX	COM NEW	88032L605	24.7	0.4%	1,700,000		Added+252,218
Capricor Therapeutics IncCAPR	COM NEW	14070B309	24.1	0.4%	1,000,000	Call	New+1,000,000
Sellas Life Sciences Group ISLS	COM NEW	81642T209	22.1	0.3%	1,500,000	Put	New+1,500,000
Nautilus Biotechnology IncNAUT	COM	63909J108	21.8	0.3%	11,634,211		Reduced−960,000
Orchestra Biomed Holdings IncOBIO	COM	68572M106	21.7	0.3%	5,037,906		Unchanged
Intuitive Surgical IncISRG	COM NEW	46120E602	20.6	0.3%	51,884		Reduced−33,535
Adlai Nortye LtdANL	SPONSORED ADS	00704R109	20.6	0.3%	1,793,190		New+1,793,190
Contineum Therapeutics IncCTNM	CL A	21217B100	20.6	0.3%	1,255,592		Unchanged
Nuvectis Pharma IncNVCT	COM	67080T108	18.4	0.3%	1,000,000		New+1,000,000
Palisade Bio IncPALI	COM	696389402	17.6	0.3%	8,425,065		Reduced−503,084
Omada Health IncOMDA	COM	68170A108	17.3	0.3%	786,330		Unchanged
Leonabio IncLONA	COM	04746L203	17.1	0.3%	1,859,322		Unchanged
Evolus IncEOLS	COM	30052C107	17.1	0.3%	2,459,285		Added+1,172,423
Newamsterdam Pharma Company	ORDINARY SHARES	N62509109	16.9	0.3%	500,000	Put	New+500,000
Invivyd IncIVVD	COM	00534A102	16.1	0.2%	18,490,636		Reduced−2,368,667
Celcuity Inc	NOTE 2.750% 8/0	15102KAA8	14.6	0.2%	$6,500,000 principal		Unchanged
Mirum Pharmaceuticals IncMIRM	COM	604749101	13.5	0.2%	115,391		New+115,391
Surrozen IncSRZN	COM NEW	86889P208	13.1	0.2%	503,985		Added+274,592
Beta Bionics IncBBNX	COM	08659B102	13.1	0.2%	832,944		Reduced−10,000
Capricor Therapeutics IncCAPR	COM NEW	14070B309	12.0	0.2%	500,000	Put	New+500,000
Axogen IncAXGN	COM	05463X106	11.4	0.2%	247,312		Reduced−450,000
Oscar Health IncOSCR	CL A	687793109	11.4	0.2%	400,000		New+400,000
Oculis Holding AG	ORDINARY SHARES	H5870P102	11.2	0.2%	808,827		Added+315,000
Seaport Therapeutics IncSPTX	COMMON STOCK	81221K108	10.9	0.2%	500,000		New+500,000
Viridian Therapeutics IncVRDN	COM	92790C104	10.7	0.2%	581,980		Reduced−588,849
Boston Scientific CorpBSX	COM	101137107	10.7	0.2%	250,000		New+250,000
Billiontoone IncBLLN	CL A	090168105	10.4	0.2%	86,812		Reduced−5,000
Abivax SAABVX	SPONSORED ADS	00370M103	9.9	0.1%	74,000		Reduced−254,884
Natera IncNTRA	COM	632307104	9.4	0.1%	34,689		New+34,689
Engene Therapeutics IncENGN	COM	29286X101	8.3	0.1%	4,822,169		New+4,822,169
Research Alliance Corp III	ORD SHS CL A	G75226103	8.0	0.1%	750,000		New+750,000
Agomab Therapeutics NVAGMB	SPONSORED ADS	00860C102	7.8	0.1%	600,000		Unchanged
Cullinan Therapeutics IncCGEM	COM	230031106	7.8	0.1%	426,478		New+426,478
Uniqure NV	SHS	N90064101	7.7	0.1%	168,000		New+168,000
Mobia Med IncMOBI	COMMON STOCK	60705V103	7.0	0.1%	523,654		New+523,654
Adagio Med Holdings IncADGM	COM	00534B100	6.4	<0.1%	9,876,586		Added+10
Guardant Health IncGH	COM	40131M109	6.2	<0.1%	41,327		Reduced−258,673
Phathom Pharmaceuticals IncPHAT	COM	71722W107	5.8	<0.1%	532,000		Reduced−393,000
Outlook Therapeutics IncOTLK	COM	69012T305	5.0	<0.1%	3,139,216		New+3,139,216
Cogent Biosciences IncCOGT	COM	19240Q201	4.7	<0.1%	121,082		Unchanged
Edesa Biotech IncEDSA	COM NEW	27966L306	4.6	<0.1%	563,239		Unchanged
Avalo Therapeutics IncAVTX	COM NEW	05338F306	4.1	<0.1%	219,813		Added+80,146
Twist Bioscience CorpTWST	COM	90184D100	3.8	<0.1%	36,812		Reduced−113,188
Crescent Biopharma Inc.	COM	G2545C104	3.7	<0.1%	206,942		Unchanged
Xeris Biopharma Holdings IncXERS	COM	98422E103	3.7	<0.1%	467,013		New+467,013
Outset Med IncOM	COM NEW	690145206	3.6	<0.1%	833,333		Unchanged
Biodesix IncBDSX	COM	09075X207	2.5	<0.1%	108,694		New+108,694
Revolution Medicines IncRVMD	*W EXP 12/17/202	76155X118	2.3	<0.1%	250,000		Unchanged
Connect Biopharma Holdings Ltd	SHS	G23549101	1.9	<0.1%	792,696		Unchanged
Kiora Pharmaceuticals IncKPRX	COM	49721T507	1.2	<0.1%	438,471		New+438,471
Medline IncMDLN	COM CL A	58507V107	1.1	<0.1%	28,000		Unchanged
Adma Biologics IncADMA	COM	000899104	1.0	<0.1%	113,765		Reduced−353,468
Cumberland Pharmaceuticals ICPIX	COM	230770109	0.6	<0.1%	96,982		Reduced−99,996
Exagen IncXGN	COM	30068X103	0.5	<0.1%	114,893		Unchanged
Ensysce Biosciences IncENSC	COM NEW	293602504	0.0	<0.1%	86,666		Unchanged
Surrozen Inc	*W EXP 08/01/203	86889P117	0.0	<0.1%	166,666		Unchanged

Sold out: 14 positions

Held at the end of the quarter before and not reported this quarter.

PERCEPTIVE ADVISORS LLC, positions sold out
Issuer	Class	CUSIP	Weight	Put or call	Change on the quarter before
Apellis Pharmaceuticals Inc	COM	03753U106	0.0%		Sold out−80,956
Ascendis Pharma A/S	SPONSORED ADR	04351P101	0.0%		Sold out−1,531,421
Belite Bio IncBLTE	SPONSORED ADS	07782B104	0.0%		Sold out−151,979
Bright Minds Biosciences IncDRUG	COM NEW	10919W405	0.0%		Sold out−377,544
Centessa Pharmaceuticals plc	SPONSORED ADS	152309100	0.0%		Sold out−5,258,903
DAY One Biopharmaceuticals I	COM	23954D109	0.0%		Sold out−1,755,799
Engene Holdings Inc	COM	29286M105	0.0%		Sold out−5,827,506
Evommune IncEVMN	COM SHS	30054Y107	0.0%		Sold out−448,350
Inhibikase Therapeutics IncIKT	COM NEW	45719W205	0.0%		Sold out−2,315,000
Neumora Therapeutics Inc.NMRA	COM	640979100	0.0%		Sold out−5,104,097
Neurocrine Biosciences IncNBIX	COM	64125C109	0.0%		Sold out−65,050
Ocular Therapeutix IncOCUL	COM	67576A100	0.0%	Call	Sold out−500,000
Opus Genetics IncIRD	COM	67577R102	0.0%		Sold out−1,835,842
Palatin Technologies IncPTN	COM NEW	696077601	0.0%		Sold out−61,945

Source: SEC EDGAR, Form 13F-HR, accession 0001012975-26-000777 (on sec.gov). Last ingested by Listed: Oct 22, 2026, 05:26 ET. Listed shows no prices and gives no investment advice.