RA CAPITAL MANAGEMENT, L.P.

Name: RA CAPITAL MANAGEMENT, L.P.: Form 13F holdings for the quarter ended 2026-06-30
Creator: Listed

An institutional investment manager in BOSTON, MA. Its Form 13F for the quarter ended Jun 30, 2026, filed Aug 14, 2026. SEC CIK 1346824.

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Reported value$11.51bn
Positions84

Holdings: 84 positions

The filing on sec.gov

As filed, largest first. Reported value is what the manager stated for each position at the quarter end, in US dollars; it is filing data, not a price. Weight is the position's share of the total reported value. Changes compare with the 13F for the quarter ended 2026-03-31. The filing's table has 85 lines; lines for the same security and option type are added together here.

RA CAPITAL MANAGEMENT, L.P., holdings
Issuer	Class	CUSIP	Reported value$m	Weight	Shares	Change on the quarter before
Ascendis Pharma A/S	Common Stock	K08588103	2,742	23.8%	10,281,496	New+10,281,496
Parabilis Medicines IncPBLS	Common Stock	698955101	792	6.9%	28,933,371	New+28,933,371
Rhythm Pharmaceuticals IncRYTM	Common Stock	76243J105	740	6.4%	6,666,837	Unchanged
Vaxcyte IncPCVX	Common Stock	92243G108	667	5.8%	11,474,599	Unchanged
Sionna Therapeutics IncSION	Common Stock	829401108	436	3.8%	9,905,045	Unchanged
Tyra Biosciences IncTYRA	Common Stock	90240B106	390	3.4%	12,198,625	Unchanged
Edgewise Therapeutics IncEWTX	Common Stock	28036F105	341	3.0%	8,392,730	Reduced−2,035,707
Newamsterdam Pharma Co NV	Common Stock	N62509109	324	2.8%	9,550,191	Unchanged
Hemab Therapeutics HoldingsCOAG	Common Stock	423494103	287	2.5%	7,808,627	New+7,808,627
Septerna IncSEPN	Common Stock	81734D104	234	2.0%	6,995,858	Unchanged
Bicara Therapeutics IncBCAX	Common Stock	055477103	215	1.9%	7,255,993	Unchanged
Mineralys Therapeutics IncMLYS	Common Stock	603170101	208	1.8%	7,692,750	Unchanged
GH Research plc	Common Stock	G3855L106	205	1.8%	7,636,813	Reduced−39,884
Disc Medicine IncIRON	Common Stock	254604101	179	1.6%	2,450,221	Unchanged
Spyglass Pharma IncSGP	Common Stock	85220G109	179	1.6%	8,021,117	Unchanged
Artiva Biotherapeutics IncARTV	Common Stock	04317A107	174	1.5%	17,955,642	Added+8,102,340
Janux Therapeutics IncJANX	Common Stock	47103J105	172	1.5%	11,189,693	Unchanged
Taysha Gene Therapies IncTSHA	Common Stock	877619106	160	1.4%	23,555,648	Unchanged
Biocryst Pharmaceuticals IncBCRX	Common Stock	09058V103	158	1.4%	15,827,186	Unchanged
Wave Life Sciences Ltd	Common Stock	Y95308105	157	1.4%	26,975,505	Unchanged
Nuvalent Inc-A	Common Stock	670703107	154	1.3%	1,246,456	Reduced−1,287,689
Abivax Sa-AdrABVX	ADR	00370M103	151	1.3%	1,132,557	New+1,132,557
Oruka Therapeutics IncORKA	Common Stock	687604108	148	1.3%	1,554,597	New+1,554,597
Climb Bio IncCLYM	Common Stock	28658R106	147	1.3%	11,300,939	Unchanged
Solid Biosciences IncSLDB	Common Stock	83422E204	120	1.0%	12,036,126	Added+2,696,148
ZAI Lab Ltd-AdrZLAB	ADR	98887Q104	109	0.9%	5,743,533	Added+36,271
ARS Pharmaceuticals IncSPRY	Common Stock	82835W108	87.0	0.8%	10,860,977	Unchanged
Xencor IncXNCR	Common Stock	98401F105	84.9	0.7%	5,274,274	Added+377,037
Jade Biosciences IncJBIO	Common Stock	008064206	81.6	0.7%	3,671,083	Unchanged
Intellia Therapeutics IncNTLA	Common Stock	45826J105	76.6	0.7%	4,526,926	New+4,526,926
LB Pharmaceuticals IncLBRX	Common Stock	50180M108	71.7	0.6%	2,208,604	Unchanged
Definium Therapeutics IncDFTX	Common Stock	24477V105	70.6	0.6%	1,500,000	New+1,500,000
Aclaris Therapeutics IncACRS	Common Stock	00461U105	67.3	0.6%	12,723,026	Added+5,918,954
4D Molecular Therapeutics inFDMT	Common Stock	35104E100	67.2	0.6%	5,049,779	Unchanged
Sana Biotechnology IncSANA	Common Stock	799566104	65.4	0.6%	18,750,000	New+18,750,000
Damora Therapeutics Inc	Common Stock	36322Q206	62.4	0.5%	2,399,702	Added+392
Monopar Therapeutics IncMNPR	Common Stock	61023L207	61.8	0.5%	667,207	Unchanged
Acumen Pharmaceuticals IncABOS	Common Stock	00509G209	56.1	0.5%	20,992,669	Unchanged
Geron CorpGERN	Common Stock	374163103	54.8	0.5%	42,809,751	Reduced−20,961,615
Rezolute IncRZLT	Common Stock	76200L309	49.1	0.4%	9,445,039	Added+265,039
Evommune IncEVMN	Common Stock	30054Y107	46.4	0.4%	3,494,638	Unchanged
VOR Biopharma IncVOR	Common Stock	929033207	44.2	0.4%	2,402,095	Reduced−3,002,903
Century Therapeutics IncIPSC	Common Stock	15673T100	43.5	0.4%	17,754,430	Unchanged
Aktis Oncology IncAKTS	Common Stock	01021M104	42.4	0.4%	1,314,405	Reduced−188,679
Bioage Labs IncBIOA	Common Stock	09077V100	41.0	0.4%	1,671,648	Added+21,000
C4 Therapeutics IncCCCC	Common Stock	12529R107	37.4	0.3%	8,000,000	Unchanged
Mirum Pharmaceuticals IncMIRM	Common Stock	604749101	37.3	0.3%	318,554	Unchanged
Capricor Therapeutics IncCAPR	Common Stock	14070B309	36.3	0.3%	1,507,844	Unchanged
Pepgen IncPEPG	Common Stock	713317105	36.1	0.3%	20,064,545	Unchanged
Prelude Therapeutics IncPRLD	Common Stock	74065P101	34.5	0.3%	6,475,882	New+6,475,882
Nkarta IncNKTX	Common Stock	65487U108	30.6	0.3%	10,805,129	Unchanged
Q32 Bio IncQTTB	Common Stock	746964105	29.7	0.3%	2,332,457	New+2,332,457
Anteris Technologies GlobalAVR	Common Stock	03675P102	29.6	0.3%	3,000,000	Unchanged
Editas Medicine IncEDIT	Common Stock	28106W103	28.8	0.3%	8,889,000	New+8,889,000
Ovid Therapeutics IncOVID	Common Stock	690469101	28.2	0.2%	10,500,968	Reduced−213,032
Assembly Biosciences IncASMB	Common Stock	045396207	28.0	0.2%	1,020,410	Unchanged
ALX Oncology Holdings IncALXO	Common Stock	00166B105	26.9	0.2%	13,011,849	Unchanged
Benitec Biopharma IncBNTC	Common Stock	08205P209	24.8	0.2%	1,850,000	Unchanged
Lenz Therapeutics IncLENZ	Common Stock	52635N103	23.7	0.2%	4,178,823	Unchanged
Lexeo Therapeutics IncLXEO	Common Stock	52886X107	23.3	0.2%	5,000,000	Unchanged
Acrivon Therapeutics IncACRV	Common Stock	004890109	21.8	0.2%	12,229,396	Added+3,888,888
Altimmune IncALT	Common Stock	02155H200	19.8	0.2%	6,500,000	New+6,500,000
Karyopharm Therapeutics IncKPTI	Common Stock	48576U205	18.7	0.2%	1,917,354	Unchanged
Bright Minds Biosciences IncDRUG	Common Stock	10919W405	18.6	0.2%	265,000	Unchanged
Avalo Therapeutics IncAVTX	Common Stock	05338F306	18.5	0.2%	1,000,000	Added+337,032
Onkure Therapeutics Inc-AOKUR	Common Stock	68277Q105	18.2	0.2%	3,998,333	Unchanged
Faeth Therapeutics IncFTH	Common Stock	81728A207	18.1	0.2%	722,020	New+722,020
Aura Biosciences IncAURA	Common Stock	05153U107	17.8	0.2%	2,500,000	New+2,500,000
SAB Biotherapeutics IncSABS	Common Stock	78397T202	17.2	0.1%	4,401,500	Unchanged
Seaport Therapeutics IncSPTX	Common Stock	81221K108	15.2	0.1%	700,000	New+700,000
Palisade Bio IncPALI	Common Stock	696389402	14.9	0.1%	7,124,116	Unchanged
Helix Acquisition Corp-Cl a	Common Stock	G4444S107	13.3	0.1%	1,250,000	Unchanged
Waystar Holding CorpWAY	Common Stock	946784105	10.9	<0.1%	529,400	Unchanged
Equillium IncEQ	Common Stock	29446K106	9.9	<0.1%	3,096,336	Unchanged
Macrogenics IncMGNX	Common Stock	556099109	8.6	<0.1%	1,864,176	Unchanged
Perceptive Capital Solutions	Common Stock	G70077105	8.2	<0.1%	750,000	Unchanged
Adicet Bio IncACET	Common Stock	007002207	8.1	<0.1%	932,624	Reduced−250,000
Newamsterdam Pharma Co NV-27	WTS	N62509117	7.1	<0.1%	333,333	Unchanged
Corvus Pharmaceuticals IncCRVS	Common Stock	221015100	6.7	<0.1%	450,000	Unchanged
Rani Therapeutics Holdings-ARANI	Common Stock	753018100	6.5	<0.1%	8,500,000	Unchanged
Jatt II Acquisition Corp	Common Stock	G50765109	5.7	<0.1%	500,000	New+500,000
Amanat Acquisition Corp CL a	Common Stock	G0375M101	3.8	<0.1%	375,000	New+375,000
Werewolf Therapeutics IncHOWL	Common Stock	95075A107	0.9	<0.1%	2,387,744	Reduced−4,293,563
Palatin Technologies IncPTN	Common Stock	696077601	0.7	<0.1%	62,124	Reduced−7,876

Sold out: 18 positions

Held at the end of the quarter before and not reported this quarter.

RA CAPITAL MANAGEMENT, L.P., positions sold out
Issuer	Class	CUSIP	Weight	Change on the quarter before
Ascendis Pharma A/S - Adr	SPONSORED ADR	04351P101	0.0%	Sold out−10,281,496
Atrium Therapeutics IncRNA	COMMON STOCK	04965N104	0.0%	Sold out−864,102
Contineum Therapeutics Inc-ACTNM	COMMON STOCK	21217B100	0.0%	Sold out−1,296,012
Design Therapeutics IncDSGN	COMMON STOCK	25056L103	0.0%	Sold out−2,972,973
Dianthus Therapeutics IncDNTH	COMMON STOCK	252828108	0.0%	Sold out−2,611,733
Fulcrum Therapeutics IncFULC	COMMON STOCK	359616109	0.0%	Sold out−6,053,960
Genedx Holdings CorpWGS	COMMON STOCK	81663L200	0.0%	Sold out−209,887
Grail IncGRAL	COMMON STOCK	384747101	0.0%	Sold out−428,266
Hinge Health Inc-AHNGE	COMMON STOCK	433313103	0.0%	Sold out−364,613
Inspire Medical Systems IncINSP	COMMON STOCK	457730109	0.0%	Sold out−325,663
Maplight Therapeutics IncMPLT	COMMON STOCK	56565P103	0.0%	Sold out−248,294
Olema Pharmaceuticals IncOLMA	COMMON STOCK	68062P106	0.0%	Sold out−2,600,000
Praxis Precision Medicines IPRAX	COMMON STOCK	74006W207	0.0%	Sold out−373,787
Relmada Therapeutics IncRLMD	COMMON STOCK	75955J402	0.0%	Sold out−2,947,369
Sarepta Therapeutics IncSRPT	COMMON STOCK	803607100	0.0%	Sold out−3,902,596
Spyre Therapeutics IncSYRE	COMMON STOCK	00773J202	0.0%	Sold out−1,621,620
Sutro Biopharma IncSTRO	COMMON STOCK	869367201	0.0%	Sold out−715,307
Travere Therapeutics IncTVTX	COMMON STOCK	89422G107	0.0%	Sold out−746,841

Source: SEC EDGAR, Form 13F-HR, accession 0001104659-26-097251 (on sec.gov). Last ingested by Listed: Oct 22, 2026, 05:26 ET. Listed shows no prices and gives no investment advice.