DAFNA Capital Management LLC

Name: DAFNA Capital Management LLC: Form 13F holdings for the quarter ended 2026-06-30
Creator: Listed

An institutional investment manager in LOS ANGELES, CA. Its Form 13F for the quarter ended Jun 30, 2026, filed Aug 14, 2026. SEC CIK 1389933.

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Reported value$524.4m
Positions88

Holdings: 88 positions

The filing on sec.gov

As filed, largest first. Reported value is what the manager stated for each position at the quarter end, in US dollars; it is filing data, not a price. Weight is the position's share of the total reported value. Changes compare with the 13F for the quarter ended 2026-03-31.

DAFNA Capital Management LLC, holdings
Issuer	Class	CUSIP	Reported value$m	Weight	Shares	Change on the quarter before
Revolution Medicines IncRVMD	COM	76155X100	105	20.1%	562,630	Reduced−18,048
SPDR S&P Biotech ETF	ETF	78464A870	31.1	5.9%	196,505	Reduced−122,000
Compass Pathways plcCMPS	SPONSORED ADS	20451W101	28.5	5.4%	2,011,952	Reduced−406,930
Stereotaxis IncSTXS	COM NEW	85916J409	23.5	4.5%	13,680,554	Unchanged
Nektar TherapeuticsNKTR	COM NEW	640268306	22.2	4.2%	318,380	Added+153,202
Denali Therapeutics IncDNLI	COM	24823R105	19.0	3.6%	739,014	Added+420,514
Ideaya Biosciences IncIDYA	COM	45166A102	18.5	3.5%	497,240	Added+20,500
Atricure IncATRC	COM	04963C209	16.7	3.2%	597,431	Unchanged
Xenon Pharmaceuticals IncXENE	COM	98420N105	15.1	2.9%	250,772	Unchanged
Cytokinetics IncCYTK	COM NEW	23282W605	14.7	2.8%	171,998	Reduced−45,499
Arcus Biosciences IncRCUS	COM	03969F109	13.6	2.6%	441,829	Reduced−2,000
Ascendis Pharma A/S	ORD SHS	K08588103	12.9	2.5%	48,469	New+48,469
Neurocrine Biosciences IncNBIX	COM	64125C109	9.7	1.9%	57,769	Reduced−12,846
Axogen IncAXGN	COM	05463X106	9.7	1.8%	208,960	Reduced−41,000
Insulet CorpPODD	COM	45784P101	9.4	1.8%	61,870	Added+51,000
Edgewise Therapeutics IncEWTX	COM	28036F105	9.2	1.8%	226,819	Added+114,583
Bicara Therapeutics IncBCAX	COM	055477103	8.5	1.6%	284,955	Reduced−136,778
Ishares Nasdaq Biotech Indx	ETF	464287556	8.1	1.5%	42,595	Reduced−19,500
Syndax Pharmaceuticals IncSNDX	COM	87164F105	7.3	1.4%	335,255	Added+117,900
Maplight Therapeutics IncMPLT	COM	56565P103	6.1	1.2%	171,006	Unchanged
Larimar Therapeutics IncLRMR	COM	517125100	6.1	1.2%	2,008,164	Reduced−21,000
Century Therapeutics IncIPSC	COM	15673T100	5.9	1.1%	2,400,458	Reduced−33,895
Dexcom IncDXCM	COM	252131107	5.8	1.1%	86,279	Unchanged
Immunovant IncIMVT	COM	45258J102	5.8	1.1%	149,524	Reduced−1,000
Inogen IncINGN	COM	45780L104	5.5	1.0%	845,179	Unchanged
Tandem Diabetes Care IncTNDM	COM	875372203	5.4	1.0%	355,208	Unchanged
Alkermes plc	SHS	G01767105	5.3	1.0%	101,266	Reduced−38,216
Stoke Therapeutics IncSTOK	COM	86150R107	4.3	0.8%	130,875	Unchanged
Allogene Therapeutics IncALLO	COM	019770106	4.2	0.8%	2,000,000	Added+629,882
Biocryst Pharmaceuticals IncBCRX	COM	09058V103	4.0	0.8%	400,248	Reduced−30,000
Lakefront Biotherapeutics NVLKFT	SPON ADR	36315X101	3.9	0.7%	130,175	Unchanged
Orthopediatrics CorpKIDS	COM	68752L100	3.6	0.7%	189,130	Added+93,471
Cybin Inc	COM NEW	23256X407	3.4	0.6%	514,061	Added+15,700
Rapport Therapeutics IncRAPP	COM	75383L102	3.1	0.6%	75,000	Unchanged
Kymera Therapeutics IncKYMR	COM	501575104	3.1	0.6%	27,000	New+27,000
Proqr Therapeutics NV	SHS EURO	N71542109	2.8	0.5%	1,530,361	Reduced−37,200
Neurogene IncNGNE	COM	64135M105	2.8	0.5%	89,032	Added+32,397
Adlai Nortye LtdANL	SPONSORED ADS	00704R109	2.8	0.5%	239,553	New+239,553
Procept Biorobotics CorpPRCT	COM	74276L105	2.7	0.5%	120,000	Unchanged
Aquestive Therapeutics IncAQST	COM	03843E104	2.7	0.5%	645,915	Added+277,500
Celldex Therapeutics IncCLDX	COM NEW	15117B202	2.5	0.5%	68,518	Unchanged
Structure Therapeutics IncGPCR	SPONSORED ADS	86366E106	2.5	0.5%	46,500	Unchanged
Align Technology IncALGN	COM	016255101	2.4	0.5%	14,000	Reduced−1,000
Viking Therapeutics IncVKTX	COM	92686J106	2.3	0.4%	59,516	Unchanged
Nervgen Pharma CorpNGEN	COM	64082X203	2.2	0.4%	1,050,000	New+1,050,000
Biohaven Ltd	COM	G1110E107	2.0	0.4%	137,593	Reduced−708,142
Maze Therapeutics IncMAZE	COM	578784100	1.9	0.4%	65,000	Added+30,000
Alector IncALEC	COM	014442107	1.8	0.3%	908,351	Unchanged
Lexeo Therapeutics IncLXEO	COM	52886X107	1.8	0.3%	377,059	Unchanged
Profound Medical CorpPROF	COM NEW	74319B502	1.7	0.3%	260,360	Reduced−2,645
Atrium Therapeutics IncRNA	COM	04965N104	1.7	0.3%	128,000	New+128,000
Annexon IncANNX	COM	03589W102	1.7	0.3%	297,812	Added+180,000
Cytomx Therapeutics IncCTMX	COM	23284F105	1.6	0.3%	438,407	Added+208,407
Ultragenyx Pharmaceutical IncRARE	COM	90400D108	1.6	0.3%	47,100	Reduced−14,000
Eupraxia Pharmaceuticals IncEPRX	COM	29842P105	1.5	0.3%	225,600	New+225,600
Design Therapeutics IncDSGN	COM	25056L103	1.5	0.3%	102,600	New+102,600
Fate Therapeutics IncFATE	COM	31189P102	1.4	0.3%	525,000	Reduced−25,000
Mediwound Ltd	SHS NEW	M68830112	1.4	0.3%	94,405	Unchanged
Kura Oncology IncKURA	COM	50127T109	1.3	0.3%	120,568	Reduced−115,300
ARS Pharmaceuticals IncSPRY	COM	82835W108	1.3	0.3%	164,285	Added+25,000
Mineralys Therapeutics IncMLYS	COM	603170101	1.2	0.2%	44,490	Added+6,000
Immatics NV	SHS	N44445109	1.2	0.2%	116,960	Reduced−108,900
Tela Bio IncTELA	COM	872381108	1.1	0.2%	1,441,029	Unchanged
Polypid Ltd	COM	M8001Q126	1.1	0.2%	207,900	Unchanged
Corbus Pharmaceuticals HoldingsCRBP	COM NEW	21833P301	1.0	0.2%	107,773	New+107,773
Inspire Medical Systems IncINSP	COM	457730109	0.8	0.2%	18,200	Unchanged
Adicet Bio IncACET	COM NEW	007002207	0.8	0.2%	93,812	Unchanged
Seaport Therapeutics IncSPTX	COMMON STOCK	81221K108	0.7	0.1%	32,400	New+32,400
MBX Biosciences IncMBX	COM	55287L101	0.7	0.1%	11,809	Reduced−163,656
Biontech SEBNTX	SPONSORED ADS	09075V102	0.7	0.1%	7,000	Unchanged
Artiva Biotherapeutics IncARTV	COM	04317A107	0.7	0.1%	67,101	New+67,101
Pliant Therapeutics IncPLRX	COM	729139105	0.6	0.1%	487,000	Unchanged
Scynexis IncSCYX	COM	811292309	0.6	0.1%	135,868	New+135,868
Editas Medicine IncEDIT	COM	28106W103	0.6	0.1%	170,470	New+170,470
Orchestra Biomed Holdings IncOBIO	COM	68572M106	0.5	0.1%	126,841	Unchanged
Foghorn Therapeutics IncFHTX	COM	344174107	0.5	0.1%	111,859	Unchanged
Accuray IncARAY	COM	004397105	0.4	<0.1%	1,680,508	Unchanged
Q32 Bio IncQTTB	COM	746964105	0.4	<0.1%	32,896	New+32,896
Nuvectis Pharma IncNVCT	COM	67080T108	0.4	<0.1%	20,000	New+20,000
Compugen Ltd	ORD	M25722105	0.4	<0.1%	168,232	Reduced−89,551
Ibio IncIBIO	COM NEW	451033708	0.3	<0.1%	170,053	Reduced−23,585
Autolus Therapeutics LtdAUTL	SPON ADS	05280R100	0.3	<0.1%	179,316	Unchanged
Bicycle Therapeutics plcBCYC	SPONSORED ADS	088786108	0.3	<0.1%	64,492	Unchanged
Tenaya Therapeutics IncTNYA	COM	87990A106	0.2	<0.1%	300,000	New+300,000
Verrica Pharmaceuticals IncVRCA	COM SHS	92511W207	0.1	<0.1%	23,750	Reduced−129,962
Engene Therapeutics IncENGN	COM	29286X101	0.1	<0.1%	74,650	New+74,650
Kardigan IncKARD	COM	485925101	0.1	<0.1%	5,000	New+5,000
ADC Therapeutics SA	SHS	H0036K147	0.1	<0.1%	77,081	Added+5,000

Sold out: 12 positions

Held at the end of the quarter before and not reported this quarter.

DAFNA Capital Management LLC, positions sold out
Issuer	Class	CUSIP	Weight	Shares	Change on the quarter before
Ascendis Pharma A/S	SPONSORED ADR	04351P101	0.0%	0	Sold out−23,177
Ascendis Pharma A/S	NOTE 2.250% 4/0	04351PAD3	0.0%	$0 principal	Sold out−4,000,000
DAY One Biopharmaceuticals I	COM	23954D109	0.0%	0	Sold out−978,463
Engene Holdings Inc	COM	29286M105	0.0%	0	Sold out−187,353
Fulcrum Therapeutics IncFULC	COM	359616109	0.0%	0	Sold out−205,000
Kalvista Pharmaceuticals Inc	COM	483497103	0.0%	0	Sold out−267,402
Karyopharm Therapeutics IncKPTI	COM NEW	48576U205	0.0%	0	Sold out−45,800
Neumora Therapeutics IncNMRA	COM	640979100	0.0%	0	Sold out−70,000
Newamsterdam Pharma Co	ORDINARY SHARES	N62509109	0.0%	0	Sold out−20,000
Oric Pharmaceuticals IncORIC	COM	68622P109	0.0%	0	Sold out−98,724
Scynexis Inc	COM NEW	811292200	0.0%	0	Sold out−1,086,956
Zenas Biopharma IncZBIO	COM	98937L105	0.0%	0	Sold out−42,500

Source: SEC EDGAR, Form 13F-HR, accession 0001389933-26-000006 (on sec.gov). Last ingested by Listed: Oct 22, 2026, 05:26 ET. Listed shows no prices and gives no investment advice.