RTW INVESTMENTS, LP

Name: RTW INVESTMENTS, LP: Form 13F holdings for the quarter ended 2026-06-30
Creator: Listed

An institutional investment manager in NEW YORK, NY. Its Form 13F for the quarter ended Jun 30, 2026, filed Aug 14, 2026. SEC CIK 1493215.

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Reported value$11.71bn
Positions84

Holdings: 84 positions

The filing on sec.gov

As filed, largest first. Reported value is what the manager stated for each position at the quarter end, in US dollars; it is filing data, not a price. Weight is the position's share of the total reported value. Changes compare with the 13F for the quarter ended 2026-03-31.

RTW INVESTMENTS, LP, holdings
Issuer	Class	CUSIP	Reported value$m	Weight	Shares	Change on the quarter before
Madrigal Pharmaceuticals IncMDGL	COM	558868105	1,071	9.1%	1,993,687	Unchanged
Argenx SEARGX	SPONSORED ADR	04016X101	658	5.6%	709,446	Unchanged
PTC Therapeutics IncPTCT	COM	69366J200	632	5.4%	7,746,415	Unchanged
Protagonist Therapeutics IncPTGX	COM	74366E102	620	5.3%	5,061,175	Added+2,122
CG Oncology IncCGON	COM	156944100	605	5.2%	8,514,590	Added+1,529,782
Insmed IncINSM	COM PAR $.01	457669307	516	4.4%	4,842,880	Unchanged
Tango Therapeutics IncTNGX	COM	87583X109	435	3.7%	13,900,620	Added+600,000
Spyre Therapeutics IncSYRE	COM NEW	00773J202	377	3.2%	4,251,996	Added+80,000
Celcuity IncCELC	COM	15102K100	346	3.0%	3,304,903	Added+265,282
Erasca IncERAS	COM	29479A108	329	2.8%	17,946,754	Added+1,789,579
Radnet IncRDNT	COM	750491102	299	2.6%	4,846,958	Added+561,958
Oruka Therapeutics IncORKA	COM	687604108	299	2.6%	3,139,030	Added+1,080,882
Natera IncNTRA	COM	632307104	271	2.3%	1,000,000	Reduced−250,000
Ultragenyx Pharmaceutical inRARE	COM	90400D108	260	2.2%	7,796,895	Added+4,148,100
Irhythm Holdings IncIRTC	COM	450056106	260	2.2%	2,182,631	Added+514,131
Cytokinetics IncCYTK	COM NEW	23282W605	244	2.1%	2,862,003	Added+140,845
Kailera Therapeutics IncKLRA	COMMON STOCK	482931102	237	2.0%	10,776,820	New+10,776,820
Establishment Labs Holdings Inc	COM	G31249108	228	1.9%	2,655,695	Unchanged
Guardant Health IncGH	COM	40131M109	222	1.9%	1,481,033	Unchanged
Neurocrine Biosciences IncNBIX	COM	64125C109	214	1.8%	1,267,925	Added+205,853
Tarsus Pharmaceuticals IncTARS	COM	87650L103	211	1.8%	3,357,059	Added+11,034
Stoke Therapeutics IncSTOK	COM	86150R107	184	1.6%	5,623,525	Unchanged
Uniqure NV	SHS	N90064101	182	1.5%	3,941,572	Added+1,355,216
Acadia Pharmaceuticals IncACAD	COM	004225108	181	1.5%	7,144,524	Unchanged
Repligen CorpRGEN	COM	759916109	169	1.4%	1,240,637	Added+34,637
Urogen Pharma Ltd	COM	M96088105	167	1.4%	4,543,895	Unchanged
GH Research plc	ORDINARY SHARES	G3855L106	160	1.4%	5,933,815	Unchanged
Immunocore Holdings plcIMCR	ADS	45258D105	155	1.3%	4,869,798	Unchanged
Compass Pathways plcCMPS	SPONSORED ADS	20451W101	151	1.3%	10,700,974	Added+68,584
Immatics N.V	SHS	N44445109	131	1.1%	12,946,176	Added+76,836
ZAI Lab LtdZLAB	ADR	98887Q104	125	1.1%	6,574,032	Unchanged
Immunovant IncIMVT	COM	45258J102	122	1.0%	3,177,849	Unchanged
Belite Bio IncBLTE	SPONSORED ADS	07782B104	110	0.9%	715,332	Unchanged
Xencor IncXNCR	COM	98401F105	109	0.9%	6,777,461	Unchanged
Taysha Gene Therapies IncTSHA	COM SHS	877619106	92.3	0.8%	13,560,258	Reduced−119,990
Cogent Biosciences IncCOGT	COM	19240Q201	89.4	0.8%	2,309,021	Reduced−3,149,654
Alkermes plc	SHS	G01767105	87.6	0.7%	1,672,356	Unchanged
Structure Therapeutics IncGPCR	SPONSORED ADS	86366E106	86.3	0.7%	1,607,507	New+1,607,507
Replimune Group IncREPL	COM	76029N106	82.0	0.7%	7,411,581	Added+54,665
Castle Biosciences IncCSTL	COM	14843C105	66.3	0.6%	2,778,335	Added+20,000
Candel Therapeutics IncCADL	COM	137404109	66.1	0.6%	6,422,018	Unchanged
Rocket Pharmaceuticals IncRCKT	COM	77313F106	60.5	0.5%	17,687,772	Unchanged
Kodiak Sciences IncKOD	COM	50015M109	58.0	0.5%	1,487,934	Unchanged
Aktis Oncology IncAKTS	COM	01021M104	51.3	0.4%	1,592,043	Unchanged
Axogen IncAXGN	COM	05463X106	46.7	0.4%	1,011,576	New+1,011,576
Danaher Corp DelDHR	COM	235851102	43.8	0.4%	230,000	New+230,000
Cullinan Therapeutics IncCGEM	COM	230031106	43.1	0.4%	2,364,347	Added+658,387
Neurogene IncNGNE	COM	64135M105	42.8	0.4%	1,362,456	Unchanged
Hinge Health IncHNGE	CL A	433313103	41.5	0.4%	500,000	Reduced−1,430,000
Orchestra Biomed Holdings IncOBIO	COM	68572M106	41.2	0.4%	9,556,063	Added+1,250,000
Solid Biosciences IncSLDB	COM NEW	83422E204	38.9	0.3%	3,892,926	New+3,892,926
Savara IncSVRA	COM	805111101	36.7	0.3%	5,952,380	Unchanged
Aquestive Therapeutics IncAQST	COM	03843E104	30.9	0.3%	7,426,471	Unchanged
Kymera Therapeutics IncKYMR	COM	501575104	27.5	0.2%	240,000	Unchanged
Verastem IncVSTM	COM NEW	92337C203	25.3	0.2%	6,635,793	Added+59,487
Dianthus Therapeutics IncDNTH	COM	252828108	24.2	0.2%	248,063	Unchanged
Beta Bionics IncBBNX	COM	08659B102	23.5	0.2%	1,500,000	Reduced−500,000
Century Therapeutics IncIPSC	COM	15673T100	21.3	0.2%	8,695,652	Unchanged
Evommune IncEVMN	COM SHS	30054Y107	20.0	0.2%	1,502,235	Unchanged
Beam Therapeutics IncBEAM	COM	07373V105	19.6	0.2%	570,394	Unchanged
Definium Therapeutics IncDFTX	COM SHS	24477V105	18.8	0.2%	400,000	Added+100,000
Ideaya Biosciences IncIDYA	COM	45166A102	13.8	0.1%	370,370	New+370,370
Ataibeckley Inc	COM SHS	04650F101	10.5	<0.1%	2,000,000	Unchanged
Milestone Pharmaceuticals inMIST	COM	59935V107	10.5	<0.1%	7,833,336	Added+1,502,335
Ocugen IncOCGN	COM	67577C105	10.2	<0.1%	6,666,666	Unchanged
Tenax Therapeutics IncTENX	COM NEW	88032L605	10.1	<0.1%	696,570	Added+326,324
Heartflow IncHTFL	COM	42238D107	8.7	<0.1%	295,000	Reduced−200,000
Perceptive Cap Solutions Cor	CL A ORD SHS	G70077105	8.1	<0.1%	742,500	Unchanged
Wave Life Sciences Ltd	SHS	Y95308105	7.8	<0.1%	1,350,000	Unchanged
Larimar Therapeutics IncLRMR	COM	517125100	7.8	<0.1%	2,565,999	Added+1,065,999
Lumexa Imaging Holdings IncLMRI	COM	550249106	7.3	<0.1%	650,000	Unchanged
Allogene Therapeutics IncALLO	COM	019770106	6.8	<0.1%	3,250,000	New+3,250,000
Crescent Biopharma Inc.	COM	G2545C104	6.7	<0.1%	372,856	Unchanged
4D Molecular Therapeutics inFDMT	COM	35104E100	6.3	<0.1%	475,737	Unchanged
Maze Therapeutics IncMAZE	COM	578784100	6.3	<0.1%	212,000	New+212,000
Capricor Therapeutics IncCAPR	COM NEW	14070B309	6.0	<0.1%	250,000	Unchanged
Kalaris Therapeutics IncKLRS	COM	482929106	5.3	<0.1%	1,300,000	Unchanged
Abivax SAABVX	SPONSORED ADS	00370M103	3.5	<0.1%	26,400	New+26,400
Avalo Therapeutics IncAVTX	COM NEW	05338F306	3.2	<0.1%	175,000	Reduced−681,962
Medline IncMDLN	COM CL A	58507V107	2.8	<0.1%	70,000	Unchanged
Disc Medicine IncIRON	COM	254604101	2.2	<0.1%	30,000	Unchanged
Imagenebio IncIMA	COM	45175G207	2.0	<0.1%	334,445	Unchanged
Exagen IncXGN	COM	30068X103	0.9	<0.1%	195,000	Reduced−200,231
Rocket Pharmaceuticals Inc	*W EXP 09/02/202	77313F114	0.0	<0.1%	350,000	Unchanged

Sold out: 13 positions

Held at the end of the quarter before and not reported this quarter.

RTW INVESTMENTS, LP, positions sold out
Issuer	Class	CUSIP	Weight	Change on the quarter before
Apellis Pharmaceuticals Inc	COM	03753U106	0.0%	Sold out−3,685,045
Apogee Therapeutics Inc	COM	03770N101	0.0%	Sold out−2,782,097
Arrowhead Pharmaceuticals inARWR	COM	04280A100	0.0%	Sold out−585,682
Centessa Pharmaceuticals plc	SPONSORED ADS	152309100	0.0%	Sold out−2,054,175
Compass Therapeutics IncCMPX	COM	20454B104	0.0%	Sold out−4,186,599
Crinetics Pharmaceuticals in	COM	22663K107	0.0%	Sold out−1,451,326
Fulgent Genetics IncFLGT	COM	359664109	0.0%	Sold out−1,289,000
Intuitive Surgical IncISRG	COM NEW	46120E602	0.0%	Sold out−220,000
Inventiva SAIVA	ADS	46124U107	0.0%	Sold out−1,298,702
Jade Biosciences IncJBIO	COM NEW	008064206	0.0%	Sold out−573,205
Omada Health IncOMDA	COM	68170A108	0.0%	Sold out−200,000
Stryker CorporationSYK	COM	863667101	0.0%	Sold out−100,000
Waystar HLDG CorpWAY	COM	946784105	0.0%	Sold out−1,630,000

Source: SEC EDGAR, Form 13F-HR, accession 0001493215-26-000164 (on sec.gov). Last ingested by Listed: Oct 22, 2026, 05:26 ET. Listed shows no prices and gives no investment advice.