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Siren, L.L.C.

An institutional investment manager in New York, NY. Its Form 13F for the quarter ended Jun 30, 2026, filed Aug 13, 2026. SEC CIK 2005245.

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Holdings: 117 positions

The filing on sec.gov

As filed, largest first. Reported value is what the manager stated for each position at the quarter end, in US dollars; it is filing data, not a price. Weight is the position's share of the total reported value. Changes compare with the 13F for the quarter ended 2026-03-31. The filing's table has 119 lines; lines for the same security and option type are added together here.

IssuerClassCUSIPReported value$mWeightSharesPut or callChange on the quarter before
Scholar Rock Holding CorpSRRKCOM80706P10352710.7%9,575,013Reduced−1,250,000
Kymera Therapeutics IncKYMRCOM5015751043376.8%2,935,830Reduced−251,000
Erasca IncERASCOM29479A1082094.2%11,397,781Added+153,535
Veradermics IncMANECOMMON STOCK9229671042044.1%1,655,374Added+150,000
Tango Therapeutics IncTNGXCOM87583X1091933.9%6,179,364Added+522,259
Revolution Medicines IncRVMDCOM76155X1001693.4%900,000Reduced−210,980
Bicara Therapeutics IncBCAXCOM0554771031663.4%5,602,970Reduced−200,000
Arrowhead Pharmaceuticals IncARWRCOM04280A1001402.8%1,715,476Added+100,000
BeOne Medicines AGONCSPONSORED ADS07725L1021332.7%465,000Unchanged
Edgewise Therapeutics IncEWTXCOM28036F1051292.6%3,184,629Reduced−1,245,634
Rhythm Pharmaceuticals IncRYTMCOM76243J1051262.6%1,136,275Added+410,764
Lexicon Pharmaceuticals IncLXRXCOM NEW5288723021062.2%44,303,518Unchanged
Enliven Therapeutics IncELVNCOM29337E10290.11.8%1,774,411Added+1,028,185
Spyre Therapeutics IncSYRECOM NEW00773J20286.01.7%968,598Added+150,000
Parabilis Medicines IncPBLSCOM69895510181.91.7%2,992,259New+2,992,259
Xenon Pharmaceuticals IncXENECOM98420N10579.61.6%1,318,564Unchanged
Solid Biosciences IncSLDBCOM NEW83422E20476.81.6%7,690,405Unchanged
Abivax SAABVXSPONSORED ADS00370M10376.81.6%576,000New+576,000
Hemab Therapeutics Holdings IncCOAGCOM SHS42349410376.61.6%2,086,834New+2,086,834
Arcus Biosciences IncRCUSCOM03969F10974.61.5%2,420,430Reduced−586,647
Cogent Biosciences IncCOGTCOM19240Q20172.01.5%1,859,279Added+150,000
Relay Therapeutics IncRLAYCOM75943R10268.31.4%3,650,000New+3,650,000
Taysha Gene Therapies IncTSHACOM SHS87761910667.11.4%9,846,579Added+1,016,666
Definium Therapeutics IncDFTXCOM SHS24477V10566.81.4%1,419,493Added+500,000
Stoke Therapeutics IncSTOKCOM86150R10765.31.3%1,995,347Unchanged
Disc Medicine IncIRONCOM25460410165.01.3%888,401Reduced−100,000
Cytokinetics IncCYTKCOM NEW23282W60564.71.3%758,952Added+145,000
Septerna IncSEPNCOM81734D10463.61.3%1,900,000Reduced−100,000
Olema Pharmaceuticals IncOLMACOM68062P10660.81.2%4,856,949Added+100,000
Crinetics Pharmaceuticals IncCOM22663K10753.21.1%1,420,788Reduced−482,848
Kailera Therapeutics IncKLRACOMMON STOCK48293110248.81.0%2,214,286New+2,214,286
Dyne Therapeutics, IncDYNCOM26818M10847.31.0%2,129,125Reduced−100,000
Structure Therapeutics IncGPCRSPONSORED ADS86366E10646.90.9%872,967Reduced−455,731
Taboola.com LtdORD SHSM8744T10642.10.9%8,423,410Reduced−1,546,085
Palvella Therapeutics IncPVLACOM69794710939.30.8%257,485Unchanged
Silence Therapeutics PLCSLNADS82686Q10136.40.7%3,311,438Added+400,000
Denali Therapeutics IncDNLICOM24823R10535.90.7%1,396,513Unchanged
Remitly Global IncRELYCOM75960P10434.60.7%1,543,271Unchanged
Cullinan Therapeutics IncCGEMCOM23003110634.50.7%1,893,410Added+700,000
Capital One Finl CorpCOFCOM14040H10534.40.7%171,615New+171,615
Trevi Therapeutics IncTRVICOM89532M10133.30.7%1,786,867Unchanged
Oric Pharmaceuticals IncORICCOM68622P10932.50.7%2,998,192Unchanged
Alphabet IncGOOGLCAP STK CL A02079K30532.20.7%90,000Added+24,297
Dbv Technologies SADBVTSPONSORED ADS23306J30930.50.6%1,857,362Unchanged
Absci CorpABSICOM00091E10928.70.6%2,474,764Added+674,764
Sionna Therapeutics IncSIONCOM82940110826.90.5%610,515Added+310,515
Rapport Therapeutics IncRAPPCOM75383L10226.70.5%641,469Unchanged
Amylyx Pharmaceuticals IncAMLXCOM03237H10126.60.5%1,480,586Added+250,586
Annexon IncANNXCOM03589W10225.50.5%4,458,646Added+500,000
Monopar Therapeutics IncMNPRCOM NEW61023L20725.00.5%270,118Unchanged
Oruka Therapeutics IncORKACOM68760410823.80.5%250,000New+250,000
Seaport Therapeutics IncSPTXCOMMON STOCK81221K10823.80.5%1,095,316New+1,095,316
Damora Therapeutics IncCOM NEW36322Q20623.40.5%900,000Unchanged
Tyra Biosciences IncTYRACOM90240B10623.20.5%725,000New+725,000
Zura Bio LtdCLASS A ORD SHSG9TY5A10122.00.4%3,734,866Unchanged
Taiwan Semiconductor Manufacturing Co LtdTSMSPONSORED ADS87403910021.30.4%44,700Added+2,500
NVIDIA CorpNVDACOM67066G10419.00.4%95,000Added+5,915
Rezolute IncRZLTCOM NEW76200L30917.30.4%3,328,287Unchanged
MapLight Therapeutics IncMPLTCOM56565P10316.10.3%450,000Unchanged
Neumora Therapeutics IncNMRACOM64097910014.40.3%8,497,822Unchanged
Nebius Group NVSHS CLASS AN9728410814.40.3%52,000Reduced−61,614
Microsoft CorpMSFTCOM59491810414.00.3%37,500Reduced−3,880
CytomX Therapeutics IncCTMXCOM23284F10513.00.3%3,457,711Unchanged
Generate Biomedicines IncGENBCOM SHS37092010012.40.3%736,104Unchanged
Inhibikase Therapeutics IncIKTCOM NEW45719W20511.90.2%5,850,000Unchanged
Adagene IncADAGADS00532910711.20.2%2,666,666New+2,666,666
enGene Therapeutics IncENGNCOM29286X10110.80.2%6,256,662New+6,256,662
Whitehawk Therapeutics IncWHWKCOM00032Q10410.70.2%2,337,102Added+255,102
Datadog IncDDOGCL A COM23804L10310.40.2%40,000Reduced−14,300
ServiceNow IncNOWCOM81762P1029.90.2%100,000Added+12,910
Broadcom IncAVGOCOM11135F1019.40.2%25,000Added+10,000
IONQ IncIONQCOM46222L1089.10.2%170,000Unchanged
Microsoft CorpMSFTCOM5949181049.00.2%24,000CallNew+24,000
Jfrog LtdORD SHSM6191J1008.70.2%95,500Reduced−33,316
Oculis Holding AGORDINARY SHARESH5870P1028.70.2%625,000New+625,000
IREN LtdORDINARY SHARESQ4982L1098.00.2%175,000Added+131,900
Amazon.com IncAMZNCOM0231351067.70.2%32,500Reduced−14,141
CrowdStrike Holdings IncCRWDCL A22788C1057.60.2%10,000Reduced−13,070
Design Therapeutics IncDSGNCOM25056L1037.60.2%523,212New+523,212
PDD Holdings IncPDDSPONSORED ADS7223041027.20.1%95,000Added+11,599
Satellos Bioscience IncMSLECOM80401L8036.90.1%892,074Unchanged
Dynatrace, IncDTCOM NEW2681501096.80.1%155,000Added+5,000
Apple IncAAPLCOM0378331006.70.1%23,000CallNew+23,000
Tenax Therapeutics IncTENXCOM NEW88032L6056.20.1%427,141Unchanged
vTv Therapeutics IncVTVTCL A NEW9183852046.10.1%163,000Unchanged
Eloxx Pharmaceuticals IncELOXCOM NEW29014R3015.60.1%400,000New+400,000
Agomab Therapeutics NVAGMBSPONSORED ADS00860C1025.30.1%411,250Unchanged
Alibaba Group Holding LtdBABASPONSORED ADS01609W1024.8<0.1%50,000New+50,000
Korro Bio IncKRROCOM5009461084.6<0.1%347,718Unchanged
Cellebrite DI LtdORDINARY SHARESM2197Q1074.5<0.1%311,544Unchanged
Invivyd IncIVVDCOM00534A1024.4<0.1%5,000,000Added+1,000,000
Ouster IncOUSTCOM NEW68989M2024.2<0.1%67,500New+67,500
Palisade Bio IncPALICOM6963894024.2<0.1%2,000,000New+2,000,000
Aeva Technologies IncAEVACOM NEW00835Q2024.2<0.1%145,459Added+35,459
Seer IncSEERCOM CL A81578P1064.1<0.1%2,458,673Unchanged
NovaBridge BiosciencesNBPSPONSORED ADS44975P1033.9<0.1%2,004,739Reduced−995,261
GitLab IncGTLBCLASS A COM37637K1083.8<0.1%125,000Added+25,000
Odyssey Therapeutics IncODTXCOMMON STOCK67613T1043.7<0.1%200,000New+200,000
Foghorn Therapeutics IncFHTXCOM3441741073.5<0.1%720,720Unchanged
Agenus IncAGENCOM NEW00847G8043.3<0.1%1,064,250Unchanged
monday.com LtdSHSM7S64H1063.1<0.1%42,500Added+17,500
Zoetis IncZTSCL A98978V1032.5<0.1%35,000New+35,000
Workiva IncWKCOM CL A98139A1052.2<0.1%45,000Reduced−47,500
Netflix IncNFLXCOM64110L1061.8<0.1%25,000New+25,000
Kalaris Therapeutics IncKLRSCOM4829291061.8<0.1%435,798Unchanged
Quantinuum IncQNTCL A COM74768A1041.6<0.1%20,000New+20,000
Rani Therapeutics Holdings IncRANICOM CL A7530181001.5<0.1%2,000,000Unchanged
Tesla IncTSLACOM88160R1011.5<0.1%3,500Reduced−18,000
KE Holdings IncBEKESPONSORED ADS4824971041.5<0.1%100,000Unchanged
Entera Bio LtdSHSM405271091.3<0.1%736,457New+736,457
Medline IncMDLNCOM CL A58507V1071.0<0.1%25,000Unchanged
Lumentum Holdings IncLITECOM55024U1090.9<0.1%1,055New+1,055
Figma IncFIGCLASS A COM STK3168411050.9<0.1%50,000Unchanged
Gossamer Bio IncCOM38341P1020.9<0.1%5,208,968Unchanged
Fox CorpFOXACL A COM35137L1050.5<0.1%10,000New+10,000
AT&T IncTCOM00206R1020.5<0.1%25,000New+25,000
Nu Holdings Ltd.ORD SHS CL AG6683N1030.3<0.1%25,000Unchanged

Sold out: 10 positions

Held at the end of the quarter before and not reported this quarter.

IssuerClassCUSIPReported value$WeightSharesPut or callChange on the quarter before
Amer Sports IncCOM SHSG0260P1020.00.0%0Sold out−50,000
Bicycle Therapeutics PLCBCYCSPONSORED ADS0887861080.00.0%0Sold out−1,560,882
Centessa Pharmaceuticals PLCSPONSORED ADS1523091000.00.0%0Sold out−1,053,464
enGene Holdings IncCOM29286M1050.00.0%0Sold out−5,253,159
Forgent Power Solutions, IncFPSCOM SHS CL A34631F1020.00.0%0Sold out−100,000
Fulcrum Therapeutics IncFULCCOM3596161090.00.0%0Sold out−2,350,000
Micron Technology IncMUCOM5951121030.00.0%0Sold out−6,000
Primo Brands CorpPRMBCLASS A COM SHS7416231020.00.0%0Sold out−50,000
Uniqure NVSHSN900641010.00.0%0Sold out−1,000,000
WAVE Life Sciences LtdSHSY953081050.00.0%0Sold out−2,450,000

Source: SEC EDGAR, Form 13F-HR, accession 0002005245-26-000008 (on sec.gov). Last ingested by Listed: Oct 22, 2026, 05:26 ET. Listed shows no prices and gives no investment advice.