Listed

Upstream Bio, Inc.

UPBNasdaqCIK 2022626HealthcareFiscal year ends Dec 31

Standardized line items from XBRL company facts, the last twelve quarters. Negative values are in parentheses. A figure marked d is derived from year-to-date figures.

Income statement

Revenue$773.0k, Q2 FY2026
Operating income−$42.4m, Q2 FY2026
Net income−$39.7m, Q2 FY2026
Upstream Bio, Inc., income statement, quarterly
Line itemUnitperiod not labelled2023-09-30period not labelled2023-12-31period not labelled2024-03-31period not labelled2024-06-30Q3 FY20242024-09-30Q4 FY20242024-12-31Q1 FY20252025-03-31Q2 FY20252025-06-30Q3 FY20252025-09-30Q4 FY20252025-12-31Q1 FY20262026-03-31Q2 FY20262026-06-30
Revenue$m0.6Revenue, period not labelled, three months to 2023-09-30$621.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure0.5Revenue, period not labelled, three months to 2023-12-31$450.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-K filed 2025-03-12, accession 0000950170-25-037621. Derived: 12-month figure less the 9-month figure.Report this figure0.6Revenue, period not labelled, three months to 2024-03-31$640.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure0.5Revenue, period not labelled, three months to 2024-06-30$510.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure0.6Revenue, Q3 FY2024, three months to 2024-09-30$607.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure0.6Revenue, Q4 FY2024, three months to 2024-12-31$613.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure0.6Revenue, Q1 FY2025, three months to 2025-03-31$566.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure0.9Revenue, Q2 FY2025, three months to 2025-06-30$937.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure0.7Revenue, Q3 FY2025, three months to 2025-09-30$683.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure0.7Revenue, Q4 FY2025, three months to 2025-12-31$668.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure1.0Revenue, Q1 FY2026, three months to 2026-03-31$1.0m. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure0.8Revenue, Q2 FY2026, three months to 2026-06-30$773.0k. XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Research and development$m7.8Research and development, period not labelled, three months to 2023-09-30$7.8m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure11.6Research and development, period not labelled, three months to 2023-12-31$11.6m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-K filed 2025-03-12, accession 0000950170-25-037621. Derived: 12-month figure less the 9-month figure.Report this figure11.7Research and development, period not labelled, three months to 2024-03-31$11.7m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure14.1Research and development, period not labelled, three months to 2024-06-30$14.1m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure15.4Research and development, Q3 FY2024, three months to 2024-09-30$15.4m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure21.8Research and development, Q4 FY2024, three months to 2024-12-31$21.8m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure25.8Research and development, Q1 FY2025, three months to 2025-03-31$25.8m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure37.9Research and development, Q2 FY2025, three months to 2025-06-30$37.9m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure33.0Research and development, Q3 FY2025, three months to 2025-09-30$33.0m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure40.2Research and development, Q4 FY2025, three months to 2025-12-31$40.2m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure36.6Research and development, Q1 FY2026, three months to 2026-03-31$36.6m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure36.1Research and development, Q2 FY2026, three months to 2026-06-30$36.1m. XBRL concept us-gaap:ResearchAndDevelopmentExpense. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Operating income$m(9.4)Operating income, period not labelled, three months to 2023-09-30−$9.4m. XBRL concept us-gaap:OperatingIncomeLoss. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure(14.3)Operating income, period not labelled, three months to 2023-12-31−$14.3m. XBRL concept us-gaap:OperatingIncomeLoss. 10-K filed 2025-03-12, accession 0000950170-25-037621. Derived: 12-month figure less the 9-month figure.Report this figure(15.0)Operating income, period not labelled, three months to 2024-03-31−$15.0m. XBRL concept us-gaap:OperatingIncomeLoss. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure(17.5)Operating income, period not labelled, three months to 2024-06-30−$17.5m. XBRL concept us-gaap:OperatingIncomeLoss. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure(18.9)Operating income, Q3 FY2024, three months to 2024-09-30−$18.9m. XBRL concept us-gaap:OperatingIncomeLoss. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure(26.3)Operating income, Q4 FY2024, three months to 2024-12-31−$26.3m. XBRL concept us-gaap:OperatingIncomeLoss. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure(32.0)Operating income, Q1 FY2025, three months to 2025-03-31−$32.0m. XBRL concept us-gaap:OperatingIncomeLoss. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure(44.3)Operating income, Q2 FY2025, three months to 2025-06-30−$44.3m. XBRL concept us-gaap:OperatingIncomeLoss. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure(37.8)Operating income, Q3 FY2025, three months to 2025-09-30−$37.8m. XBRL concept us-gaap:OperatingIncomeLoss. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure(46.2)Operating income, Q4 FY2025, three months to 2025-12-31−$46.2m. XBRL concept us-gaap:OperatingIncomeLoss. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure(43.6)Operating income, Q1 FY2026, three months to 2026-03-31−$43.6m. XBRL concept us-gaap:OperatingIncomeLoss. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure(42.4)Operating income, Q2 FY2026, three months to 2026-06-30−$42.4m. XBRL concept us-gaap:OperatingIncomeLoss. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Income tax$mnot reported0.0Income tax, period not labelled, three months to 2023-12-31$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-K filed 2025-03-12, accession 0000950170-25-037621. Derived: 12-month figure less the 9-month figure.Report this figure0.0Income tax, period not labelled, three months to 2024-03-31$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure0.0Income tax, period not labelled, three months to 2024-06-30$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-Q filed 2025-08-06, accession 0000950170-25-103534. Derived: 6-month figure less the 3-month figure.Report this figure0.0Income tax, Q3 FY2024, three months to 2024-09-30$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-Q filed 2025-11-05, accession 0001193125-25-265713. Derived: 9-month figure less the 6-month figure.Report this figure0.0Income tax, Q4 FY2024, three months to 2024-12-31$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure0.0Income tax, Q1 FY2025, three months to 2025-03-31$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure0.0Income tax, Q2 FY2025, three months to 2025-06-30$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-Q filed 2026-08-11, accession 0001193125-26-343417. Derived: 6-month figure less the 3-month figure.Report this figure0.0Income tax, Q3 FY2025, three months to 2025-09-30$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-Q filed 2025-11-05, accession 0001193125-25-265713. Derived: 9-month figure less the 6-month figure.Report this figure0.0Income tax, Q4 FY2025, three months to 2025-12-31$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure0.0Income tax, Q1 FY2026, three months to 2026-03-31$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure0.0Income tax, Q2 FY2026, three months to 2026-06-30$0. XBRL concept us-gaap:IncomeTaxExpenseBenefit. 10-Q filed 2026-08-11, accession 0001193125-26-343417. Derived: 6-month figure less the 3-month figure.Report this figure
Net income$m(3.1)Net income, period not labelled, three months to 2023-09-30−$3.1m. XBRL concept us-gaap:NetIncomeLoss. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure(11.8)Net income, period not labelled, three months to 2023-12-31−$11.8m. XBRL concept us-gaap:NetIncomeLoss. 10-K filed 2025-03-12, accession 0000950170-25-037621. Derived: 12-month figure less the 9-month figure.Report this figure(10.9)Net income, period not labelled, three months to 2024-03-31−$10.9m. XBRL concept us-gaap:NetIncomeLoss. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure(14.7)Net income, period not labelled, three months to 2024-06-30−$14.7m. XBRL concept us-gaap:NetIncomeLoss. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure(16.0)Net income, Q3 FY2024, three months to 2024-09-30−$16.0m. XBRL concept us-gaap:NetIncomeLoss. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure(21.2)Net income, Q4 FY2024, three months to 2024-12-31−$21.2m. XBRL concept us-gaap:NetIncomeLoss. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure(27.3)Net income, Q1 FY2025, three months to 2025-03-31−$27.3m. XBRL concept us-gaap:NetIncomeLoss. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure(40.0)Net income, Q2 FY2025, three months to 2025-06-30−$40.0m. XBRL concept us-gaap:NetIncomeLoss. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure(33.7)Net income, Q3 FY2025, three months to 2025-09-30−$33.7m. XBRL concept us-gaap:NetIncomeLoss. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure(42.5)Net income, Q4 FY2025, three months to 2025-12-31−$42.5m. XBRL concept us-gaap:NetIncomeLoss. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure(40.6)Net income, Q1 FY2026, three months to 2026-03-31−$40.6m. XBRL concept us-gaap:NetIncomeLoss. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure(39.7)Net income, Q2 FY2026, three months to 2026-06-30−$39.7m. XBRL concept us-gaap:NetIncomeLoss. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Diluted EPS$ per share(2.11)Diluted EPS, period not labelled, three months to 2023-09-30−$2.11 per share. XBRL concept us-gaap:EarningsPerShareDiluted. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figurenot reported(4.68)Diluted EPS, period not labelled, three months to 2024-03-31−$4.68 per share. XBRL concept us-gaap:EarningsPerShareDiluted. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure(6.50)Diluted EPS, period not labelled, three months to 2024-06-30−$6.50 per share. XBRL concept us-gaap:EarningsPerShareDiluted. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure(6.96)Diluted EPS, Q3 FY2024, three months to 2024-09-30−$6.96 per share. XBRL concept us-gaap:EarningsPerShareDiluted. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figurenot reported(0.51)Diluted EPS, Q1 FY2025, three months to 2025-03-31−$0.51 per share. XBRL concept us-gaap:EarningsPerShareDiluted. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure(0.74)Diluted EPS, Q2 FY2025, three months to 2025-06-30−$0.74 per share. XBRL concept us-gaap:EarningsPerShareDiluted. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure(0.63)Diluted EPS, Q3 FY2025, three months to 2025-09-30−$0.63 per share. XBRL concept us-gaap:EarningsPerShareDiluted. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figurenot reported(0.75)Diluted EPS, Q1 FY2026, three months to 2026-03-31−$0.75 per share. XBRL concept us-gaap:EarningsPerShareDiluted. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure(0.73)Diluted EPS, Q2 FY2026, three months to 2026-06-30−$0.73 per share. XBRL concept us-gaap:EarningsPerShareDiluted. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Basic EPS$ per share(2.11)Basic EPS, period not labelled, three months to 2023-09-30−$2.11 per share. XBRL concept us-gaap:EarningsPerShareBasic. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figurenot reported(4.68)Basic EPS, period not labelled, three months to 2024-03-31−$4.68 per share. XBRL concept us-gaap:EarningsPerShareBasic. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure(6.50)Basic EPS, period not labelled, three months to 2024-06-30−$6.50 per share. XBRL concept us-gaap:EarningsPerShareBasic. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure(6.96)Basic EPS, Q3 FY2024, three months to 2024-09-30−$6.96 per share. XBRL concept us-gaap:EarningsPerShareBasic. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figurenot reported(0.51)Basic EPS, Q1 FY2025, three months to 2025-03-31−$0.51 per share. XBRL concept us-gaap:EarningsPerShareBasic. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure(0.74)Basic EPS, Q2 FY2025, three months to 2025-06-30−$0.74 per share. XBRL concept us-gaap:EarningsPerShareBasic. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure(0.63)Basic EPS, Q3 FY2025, three months to 2025-09-30−$0.63 per share. XBRL concept us-gaap:EarningsPerShareBasic. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figurenot reported(0.75)Basic EPS, Q1 FY2026, three months to 2026-03-31−$0.75 per share. XBRL concept us-gaap:EarningsPerShareBasic. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure(0.73)Basic EPS, Q2 FY2026, three months to 2026-06-30−$0.73 per share. XBRL concept us-gaap:EarningsPerShareBasic. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure

Balance sheet

Cash and equivalents$79.4m, Q2 FY2026
Shareholders' equity$271.0m, Q2 FY2026
Upstream Bio, Inc., balance sheet, quarterly
Line itemUnitperiod not labelled2023-09-30period not labelled2023-12-31period not labelled2024-03-31period not labelled2024-06-30Q3 FY20242024-09-30FY20242024-12-31Q1 FY20252025-03-31Q2 FY20252025-06-30Q3 FY20252025-09-30FY20252025-12-31Q1 FY20262026-03-31Q2 FY20262026-06-30
Cash and equivalents$m47.3Cash and equivalents, period not labelled, at 2023-09-30$47.3m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure25.8Cash and equivalents, period not labelled, at 2023-12-31$25.8m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-K filed 2025-03-12, accession 0000950170-25-037621.Report this figure31.5Cash and equivalents, period not labelled, at 2024-03-31$31.5m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure47.3Cash and equivalents, period not labelled, at 2024-06-30$47.3m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure32.9Cash and equivalents, Q3 FY2024, at 2024-09-30$32.9m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure326Cash and equivalents, FY2024, at 2024-12-31$325.9m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-K filed 2026-03-26, accession 0001193125-26-126188.Report this figure71.3Cash and equivalents, Q1 FY2025, at 2025-03-31$71.3m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure45.5Cash and equivalents, Q2 FY2025, at 2025-06-30$45.5m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure72.2Cash and equivalents, Q3 FY2025, at 2025-09-30$72.2m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure102Cash and equivalents, FY2025, at 2025-12-31$101.6m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure96.7Cash and equivalents, Q1 FY2026, at 2026-03-31$96.7m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure79.4Cash and equivalents, Q2 FY2026, at 2026-06-30$79.4m. XBRL concept us-gaap:CashAndCashEquivalentsAtCarryingValue. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Current assets$mnot reported117Current assets, period not labelled, at 2023-12-31$117.0m. XBRL concept us-gaap:AssetsCurrent. 10-K filed 2025-03-12, accession 0000950170-25-037621.Report this figurenot reportednot reported227Current assets, Q3 FY2024, at 2024-09-30$227.3m. XBRL concept us-gaap:AssetsCurrent. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure479Current assets, FY2024, at 2024-12-31$479.2m. XBRL concept us-gaap:AssetsCurrent. 10-K filed 2026-03-26, accession 0001193125-26-126188.Report this figure454Current assets, Q1 FY2025, at 2025-03-31$453.8m. XBRL concept us-gaap:AssetsCurrent. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure418Current assets, Q2 FY2025, at 2025-06-30$418.3m. XBRL concept us-gaap:AssetsCurrent. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure389Current assets, Q3 FY2025, at 2025-09-30$389.0m. XBRL concept us-gaap:AssetsCurrent. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure352Current assets, FY2025, at 2025-12-31$351.8m. XBRL concept us-gaap:AssetsCurrent. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure316Current assets, Q1 FY2026, at 2026-03-31$316.3m. XBRL concept us-gaap:AssetsCurrent. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure280Current assets, Q2 FY2026, at 2026-06-30$279.6m. XBRL concept us-gaap:AssetsCurrent. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Total assets$mnot reported117Total assets, period not labelled, at 2023-12-31$117.2m. XBRL concept us-gaap:Assets. 10-K filed 2025-03-12, accession 0000950170-25-037621.Report this figurenot reportednot reported233Total assets, Q3 FY2024, at 2024-09-30$232.7m. XBRL concept us-gaap:Assets. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure482Total assets, FY2024, at 2024-12-31$481.7m. XBRL concept us-gaap:Assets. 10-K filed 2026-03-26, accession 0001193125-26-126188.Report this figure456Total assets, Q1 FY2025, at 2025-03-31$456.2m. XBRL concept us-gaap:Assets. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure421Total assets, Q2 FY2025, at 2025-06-30$420.5m. XBRL concept us-gaap:Assets. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure391Total assets, Q3 FY2025, at 2025-09-30$391.2m. XBRL concept us-gaap:Assets. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure354Total assets, FY2025, at 2025-12-31$353.8m. XBRL concept us-gaap:Assets. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure318Total assets, Q1 FY2026, at 2026-03-31$318.1m. XBRL concept us-gaap:Assets. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure281Total assets, Q2 FY2026, at 2026-06-30$281.2m. XBRL concept us-gaap:Assets. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Current liabilities$mnot reported6.5Current liabilities, period not labelled, at 2023-12-31$6.5m. XBRL concept us-gaap:LiabilitiesCurrent. 10-K filed 2025-03-12, accession 0000950170-25-037621.Report this figurenot reportednot reported10.9Current liabilities, Q3 FY2024, at 2024-09-30$10.9m. XBRL concept us-gaap:LiabilitiesCurrent. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure10.7Current liabilities, FY2024, at 2024-12-31$10.7m. XBRL concept us-gaap:LiabilitiesCurrent. 10-K filed 2026-03-26, accession 0001193125-26-126188.Report this figure9.6Current liabilities, Q1 FY2025, at 2025-03-31$9.6m. XBRL concept us-gaap:LiabilitiesCurrent. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure10.9Current liabilities, Q2 FY2025, at 2025-06-30$10.9m. XBRL concept us-gaap:LiabilitiesCurrent. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure11.9Current liabilities, Q3 FY2025, at 2025-09-30$11.9m. XBRL concept us-gaap:LiabilitiesCurrent. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure13.5Current liabilities, FY2025, at 2025-12-31$13.5m. XBRL concept us-gaap:LiabilitiesCurrent. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure13.7Current liabilities, Q1 FY2026, at 2026-03-31$13.7m. XBRL concept us-gaap:LiabilitiesCurrent. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure10.0Current liabilities, Q2 FY2026, at 2026-06-30$10.0m. XBRL concept us-gaap:LiabilitiesCurrent. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Total liabilities$mnot reported9.4Total liabilities, period not labelled, at 2023-12-31$9.4m. XBRL concept us-gaap:Liabilities. 10-K filed 2025-03-12, accession 0000950170-25-037621.Report this figurenot reportednot reported12.1Total liabilities, Q3 FY2024, at 2024-09-30$12.1m. XBRL concept us-gaap:Liabilities. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure11.9Total liabilities, FY2024, at 2024-12-31$11.9m. XBRL concept us-gaap:Liabilities. 10-K filed 2026-03-26, accession 0001193125-26-126188.Report this figure10.6Total liabilities, Q1 FY2025, at 2025-03-31$10.6m. XBRL concept us-gaap:Liabilities. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure11.8Total liabilities, Q2 FY2025, at 2025-06-30$11.8m. XBRL concept us-gaap:Liabilities. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure12.6Total liabilities, Q3 FY2025, at 2025-09-30$12.6m. XBRL concept us-gaap:Liabilities. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure14.0Total liabilities, FY2025, at 2025-12-31$14.0m. XBRL concept us-gaap:Liabilities. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure14.1Total liabilities, Q1 FY2026, at 2026-03-31$14.1m. XBRL concept us-gaap:Liabilities. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure10.2Total liabilities, Q2 FY2026, at 2026-06-30$10.2m. XBRL concept us-gaap:Liabilities. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure
Shareholders' equity$m(112)Shareholders' equity, period not labelled, at 2023-09-30−$112.2m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure(123)Shareholders' equity, period not labelled, at 2023-12-31−$123.1m. XBRL concept us-gaap:StockholdersEquity. 10-K filed 2026-03-26, accession 0001193125-26-126188.Report this figure(133)Shareholders' equity, period not labelled, at 2024-03-31−$133.4m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure(147)Shareholders' equity, period not labelled, at 2024-06-30−$146.6m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure(160)Shareholders' equity, Q3 FY2024, at 2024-09-30−$160.3m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure470Shareholders' equity, FY2024, at 2024-12-31$469.9m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure446Shareholders' equity, Q1 FY2025, at 2025-03-31$445.6m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure409Shareholders' equity, Q2 FY2025, at 2025-06-30$408.7m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure379Shareholders' equity, Q3 FY2025, at 2025-09-30$378.6m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure340Shareholders' equity, FY2025, at 2025-12-31$339.8m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure304Shareholders' equity, Q1 FY2026, at 2026-03-31$304.0m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure271Shareholders' equity, Q2 FY2026, at 2026-06-30$271.0m. XBRL concept us-gaap:StockholdersEquity. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure

Cash flow

Operating cash flow−$35.6m, Q2 FY2026
Capital expenditure$54.0k, Q4 FY2025
Upstream Bio, Inc., cash flow, quarterly
Line itemUnitperiod not labelled2023-12-31period not labelled2024-03-31period not labelled2024-06-30Q3 FY20242024-09-30Q4 FY20242024-12-31Q1 FY20252025-03-31Q2 FY20252025-06-30Q3 FY20252025-09-30Q4 FY20252025-12-31Q1 FY20262026-03-31Q2 FY20262026-06-30
Operating cash flow$m(16.1)Operating cash flow, period not labelled, three months to 2023-12-31−$16.1m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-K filed 2025-03-12, accession 0000950170-25-037621. Derived: 12-month figure less the 9-month figure.Report this figure(17.6)Operating cash flow, period not labelled, three months to 2024-03-31−$17.6m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure(8.0)Operating cash flow, period not labelled, three months to 2024-06-30−$8.0m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-Q filed 2025-08-06, accession 0000950170-25-103534. Derived: 6-month figure less the 3-month figure.Report this figure(14.0)Operating cash flow, Q3 FY2024, three months to 2024-09-30−$14.0m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-Q filed 2025-11-05, accession 0001193125-25-265713. Derived: 9-month figure less the 6-month figure.Report this figure(19.6)Operating cash flow, Q4 FY2024, three months to 2024-12-31−$19.6m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure(41.2)Operating cash flow, Q1 FY2025, three months to 2025-03-31−$41.2m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure(39.2)Operating cash flow, Q2 FY2025, three months to 2025-06-30−$39.2m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-Q filed 2026-08-11, accession 0001193125-26-343417. Derived: 6-month figure less the 3-month figure.Report this figure(22.2)Operating cash flow, Q3 FY2025, three months to 2025-09-30−$22.2m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-Q filed 2025-11-05, accession 0001193125-25-265713. Derived: 9-month figure less the 6-month figure.Report this figure(30.6)Operating cash flow, Q4 FY2025, three months to 2025-12-31−$30.6m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figure(47.9)Operating cash flow, Q1 FY2026, three months to 2026-03-31−$47.9m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure(35.6)Operating cash flow, Q2 FY2026, three months to 2026-06-30−$35.6m. XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities. 10-Q filed 2026-08-11, accession 0001193125-26-343417. Derived: 6-month figure less the 3-month figure.Report this figure
Capital expenditure$m0.0Capital expenditure, period not labelled, three months to 2023-12-31$0. XBRL concept us-gaap:PaymentsToAcquirePropertyPlantAndEquipment. 10-K filed 2025-03-12, accession 0000950170-25-037621. Derived: 12-month figure less the 9-month figure.Report this figurenot reportednot reportednot reported0.2Capital expenditure, Q4 FY2024, three months to 2024-12-31$185.0k. XBRL concept us-gaap:PaymentsToAcquirePropertyPlantAndEquipment. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figurenot reportednot reported0.1Capital expenditure, Q3 FY2025, three months to 2025-09-30$64.0k. XBRL concept us-gaap:PaymentsToAcquirePropertyPlantAndEquipment. 10-Q filed 2025-11-05, accession 0001193125-25-265713. Derived: 9-month figure less the 6-month figure.Report this figure0.1Capital expenditure, Q4 FY2025, three months to 2025-12-31$54.0k. XBRL concept us-gaap:PaymentsToAcquirePropertyPlantAndEquipment. 10-K filed 2026-03-26, accession 0001193125-26-126188. Derived: 12-month figure less the 9-month figure.Report this figurenot reportednot reported

Shares

Diluted shares (weighted)54.57m, Q2 FY2026
Upstream Bio, Inc., shares, quarterly
Line itemUnitperiod not labelled2023-09-30period not labelled2024-03-31period not labelled2024-06-30Q3 FY20242024-09-30Q1 FY20252025-03-31Q2 FY20252025-06-30Q3 FY20252025-09-30Q1 FY20262026-03-31Q2 FY20262026-06-30
Diluted shares (weighted)m shares3.0Diluted shares (weighted), period not labelled, three months to 2023-09-302,958,727 shares. XBRL concept us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding. 10-Q filed 2024-11-07, accession 0000950170-24-122793.Report this figure3.0Diluted shares (weighted), period not labelled, three months to 2024-03-312,995,607 shares. XBRL concept us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding. 10-Q filed 2025-05-06, accession 0000950170-25-063957.Report this figure3.0Diluted shares (weighted), period not labelled, three months to 2024-06-303,008,807 shares. XBRL concept us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding. 10-Q filed 2025-08-06, accession 0000950170-25-103534.Report this figure3.0Diluted shares (weighted), Q3 FY2024, three months to 2024-09-303,023,155 shares. XBRL concept us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure53.6Diluted shares (weighted), Q1 FY2025, three months to 2025-03-3153,617,723 shares. XBRL concept us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure53.8Diluted shares (weighted), Q2 FY2025, three months to 2025-06-3053,770,868 shares. XBRL concept us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure53.9Diluted shares (weighted), Q3 FY2025, three months to 2025-09-3053,930,946 shares. XBRL concept us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding. 10-Q filed 2025-11-05, accession 0001193125-25-265713.Report this figure54.3Diluted shares (weighted), Q1 FY2026, three months to 2026-03-3154,332,319 shares. XBRL concept us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding. 10-Q filed 2026-05-13, accession 0001193125-26-220584.Report this figure54.6Diluted shares (weighted), Q2 FY2026, three months to 2026-06-3054,567,976 shares. XBRL concept us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure

Shares outstanding: 54.77mShares outstanding, period not labelled, at 2026-08-0454,771,041 shares. XBRL concept dei:EntityCommonStockSharesOutstanding. 10-Q filed 2026-08-11, accession 0001193125-26-343417.Report this figure at Aug 4, 2026, from the cover of the 10-Q filed Aug 11, 2026.

Source: SEC EDGAR, XBRL company facts. Last ingested by Listed: Oct 24, 2026, 15:50 ET. Listed shows no prices and gives no investment advice.