HighVista Strategies LLC

Name: HighVista Strategies LLC: Form 13F holdings for the quarter ended 2026-06-30
Creator: Listed

An institutional investment manager in BOSTON, MA. Its Form 13F for the quarter ended Jun 30, 2026, filed Aug 14, 2026. SEC CIK 1335325.

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Reported value$438.6m
Positions147

Holdings: 147 positions

The filing on sec.gov

As filed, largest first. Reported value is what the manager stated for each position at the quarter end, in US dollars; it is filing data, not a price. Weight is the position's share of the total reported value. Changes compare with the 13F for the quarter ended 2026-03-31.

HighVista Strategies LLC, holdings
Issuer	Class	CUSIP	Reported value$m	Weight	Shares	Change on the quarter before
Invesco DB Commdy Indx TRCKDBC	UNIT	46138B103	28.2	6.4%	1,057,238	Unchanged
Abivax SAABVX	SPONSORED ADS	00370M103	15.1	3.4%	113,031	Reduced−223
Revolution Medicines IncRVMD	COM	76155X100	12.5	2.9%	66,983	Reduced−2,326
Definium Therapeutics IncDFTX	COM SHS	24477V105	11.4	2.6%	242,884	Added+57,028
Immunovant IncIMVT	COM	45258J102	10.7	2.4%	277,873	Added+52,734
Praxis Precision Medicines IPRAX	COM NEW	74006W207	10.1	2.3%	30,210	Added+3,887
Relay Therapeutics IncRLAY	COM	75943R102	9.5	2.2%	506,235	Added+84,354
Alkermes plc	SHS	G01767105	9.4	2.1%	179,256	Added+106,067
Vaxcyte IncPCVX	COM	92243G108	8.7	2.0%	149,739	Added+25,092
Tango Therapeutics IncTNGX	COM	87583X109	8.1	1.9%	260,070	Added+155,877
Liquidia CorporationLQDA	COM NEW	53635D202	7.8	1.8%	97,896	Reduced−1,848
Cogent Biosciences IncCOGT	COM	19240Q201	7.3	1.7%	188,780	Reduced−8,271
Structure Therapeutics IncGPCR	SPONSORED ADS	86366E106	7.0	1.6%	130,784	Added+6,875
Enliven Therapeutics IncELVN	COM	29337E102	7.0	1.6%	137,866	Added+64,764
Amylyx Pharmaceuticals IncAMLX	COM	03237H101	6.9	1.6%	386,080	Added+33,995
Spyre Therapeutics IncSYRE	COM NEW	00773J202	6.9	1.6%	77,807	Reduced−68,457
LB Pharmaceuticals IncLBRX	COM SHS	50180M108	6.9	1.6%	211,511	Added+37,916
Cytokinetics IncCYTK	COM NEW	23282W605	6.6	1.5%	78,003	Added+19,360
C4 Therapeutics IncCCCC	COM STK	12529R107	6.3	1.4%	1,348,136	New+1,348,136
Tyra Biosciences IncTYRA	COM	90240B106	5.9	1.3%	184,774	Added+53,470
Alumis IncALMS	COM	022307102	5.6	1.3%	199,968	Added+87,039
Pharvaris N V	COM	N69605108	5.5	1.3%	160,494	Added+62,628
Tarsus Pharmaceuticals IncTARS	COM	87650L103	5.5	1.2%	87,060	Added+34,596
Compass Pathways plcCMPS	SPONSORED ADS	20451W101	5.3	1.2%	371,120	Added+6,760
Dianthus Therapeutics IncDNTH	COM	252828108	5.0	1.1%	51,125	Added+15,538
Nurix Therapeutics IncNRIX	COM	67080M103	4.9	1.1%	203,739	Reduced−22,807
Axsome Therapeutics Inc.AXSM	COM	05464T104	4.9	1.1%	20,183	Reduced−254
Travere Therapeutics IncTVTX	COM	89422G107	4.9	1.1%	86,233	Added+49,908
Vera Therapeutics IncVERA	CL A	92337R101	4.5	1.0%	105,907	Added+36,666
Nvidia CorporationNVDA	COM	67066G104	4.4	1.0%	21,792	Reduced−628
GH Research plc	ORDINARY SHARES	G3855L106	4.3	1.0%	158,770	Reduced−54,442
Palisade Bio IncPALI	COM	696389402	4.2	1.0%	2,030,927	Added+11,601
Argenx SEARGX	SPONSORED ADR	04016X101	4.2	1.0%	4,561	Reduced−357
Maze Therapeutics IncMAZE	COM	578784100	4.1	0.9%	136,572	Added+36,722
Ocular Therapeutix IncOCUL	COM	67576A100	4.0	0.9%	408,534	Reduced−33,039
Oruka Therapeutics IncORKA	COM	687604108	4.0	0.9%	41,902	Reduced−37,009
Dyne Therapeutics IncDYN	COM	26818M108	3.8	0.9%	171,961	Reduced−10,968
Edgewise Therapeutics IncEWTX	COM	28036F105	3.7	0.8%	90,996	Reduced−935
Moonlake ImmunotherapeuticsMLTX	CLASS A ORD	61559X104	3.7	0.8%	187,946	Reduced−6,009
Insmed IncINSM	COM PAR $.01	457669307	3.3	0.8%	31,256	Added+6,940
Celldex Therapeutics Inc NewCLDX	COM NEW	15117B202	3.2	0.7%	86,964	Reduced−2,433
Amazon Com IncAMZN	COM	023135106	3.2	0.7%	13,397	Reduced−9,000
Inventiva SAIVA	ADS	46124U107	3.1	0.7%	831,442	Added+215,776
Talen Energy CorpTLN	COM	87422Q109	3.1	0.7%	8,148	Added+5,030
Relmada Therapeutics IncRLMD	COM	75955J402	3.1	0.7%	445,799	New+445,799
Protagonist Therapeutics IncPTGX	COM	74366E102	3.0	0.7%	24,460	Reduced−9,392
Erasca IncERAS	COM	29479A108	2.9	0.7%	160,328	Reduced−20,741
Viridian Therapeutics IncVRDN	COM	92790C104	2.9	0.7%	159,885	Added+25,656
Hewlett Packard Enterprise CHPE	COM	42824C109	2.7	0.6%	59,081	Reduced−30,900
Mineralys Therapeutics IncMLYS	COM	603170101	2.3	0.5%	86,085	Added+39,307
Guardant Health IncGH	COM	40131M109	2.3	0.5%	15,419	Reduced−7,938
Avalo Therapeutics IncAVTX	COM NEW	05338F306	2.3	0.5%	122,610	Added+63,988
James Hardie Inds plc	ORD SHS	G4253H101	2.2	0.5%	85,198	Added+19,600
Eyepoint IncEYPT	COM NEW	30233G209	2.2	0.5%	155,704	Reduced−27,333
Mastec IncMTZ	COM	576323109	2.1	0.5%	5,137	Added+1,510
Xenon Pharmaceuticals IncXENE	COM	98420N105	2.1	0.5%	35,318	Reduced−13,732
RBC Bearings IncRBC	COM	75524B104	2.1	0.5%	3,223	Added+560
Visa IncV	COM CL A	92826C839	2.0	0.5%	5,961	Reduced−1,180
Assembly Biosciences IncASMB	COM NEW	045396207	2.0	0.5%	73,405	Reduced−1,330
Stoke Therapeutics IncSTOK	COM	86150R107	2.0	0.5%	61,316	Reduced−1,301
Olema Pharmaceuticals IncOLMA	COM	68062P106	2.0	0.5%	160,167	Added+42,566
Rocket Cos IncRKT	COM CL A	77311W101	2.0	0.5%	125,530	Added+33,100
XPO IncXPO	COM	983793100	2.0	0.5%	9,623	Added+700
Western Digital CorpWDC	COM	958102105	1.9	0.4%	3,050	Reduced−1,050
Core Scientific Inc NewCORZ	COM	21874A106	1.9	0.4%	75,712	Reduced−27,700
Texas Instrs IncTXN	COM	882508104	1.9	0.4%	6,500	New+6,500
KBR IncKBR	COM	48242W106	1.9	0.4%	54,206	Added+14,800
Flowserve CorpFLS	COM	34354P105	1.9	0.4%	24,958	Unchanged
Alphabet IncGOOGL	CAP STK CL C	02079K107	1.8	0.4%	5,127	Reduced−350
Seagate Technology HLDNGS PL	ORD SHS	G7997R103	1.8	0.4%	1,870	Reduced−1,030
Mirum Pharmaceuticals IncMIRM	COM	604749101	1.7	0.4%	14,892	Reduced−671
Dnow IncDNOW	COM	67011P100	1.7	0.4%	132,900	New+132,900
On Semiconductor CorpON	COM	682189105	1.7	0.4%	18,200	Reduced−9,800
Nucor CorpNUE	COM	670346105	1.7	0.4%	7,600	New+7,600
USA Today Co IncTDAY	COM	36472T109	1.6	0.4%	188,500	New+188,500
Broadcom IncAVGO	COM	11135F101	1.6	0.4%	4,199	Reduced−1,400
Calumet IncCLMT	COM	131428104	1.6	0.4%	44,000	New+44,000
Qnity Electronics IncQ	COMMON STOCK	74743L100	1.6	0.4%	9,700	New+9,700
Kodiak Sciences IncKOD	COM	50015M109	1.6	0.4%	40,590	Reduced−2,979
Credo Technology Group Holdi	ORDINARY SHARES	G25457105	1.6	0.4%	5,800	New+5,800
Knight-Swift Transn Holdings inKNX	CL A	499049104	1.6	0.4%	20,100	Reduced−2,800
Brinks CoBCO	COM	109696104	1.6	0.4%	16,414	New+16,414
Astera Labs IncALAB	COM	04626A103	1.5	0.4%	3,198	New+3,198
S&P Global IncSPGI	COM	78409V104	1.5	0.4%	3,782	New+3,782
Madrigal Pharmaceuticals IncMDGL	COM	558868105	1.5	0.3%	2,852	Added+254
Equifax IncEFX	COM	294429105	1.5	0.3%	9,572	New+9,572
Rhythm Pharmaceuticals IncRYTM	COM	76243J105	1.5	0.3%	13,657	Reduced−3,139
Savara IncSVRA	COM	805111101	1.5	0.3%	242,379	Reduced−8,620
Dominos Pizza IncDPZ	COM	25754A201	1.5	0.3%	4,991	New+4,991
Belite Bio IncBLTE	SPONSORED ADS	07782B104	1.5	0.3%	9,554	Added+1,521
Micron Technology IncMU	COM	595112103	1.5	0.3%	1,260	Reduced−2,540
Ciena CorpCIEN	COM NEW	171779309	1.4	0.3%	2,925	Reduced−2,360
Celcuity IncCELC	COM	15102K100	1.4	0.3%	13,472	Added+367
QXO IncQXO	COM NEW	82846H405	1.4	0.3%	81,420	Added+55,100
Immunocore Holdings plcIMCR	ADS	45258D105	1.4	0.3%	43,185	Reduced−15,512
CG Oncology IncCGON	COM	156944100	1.3	0.3%	18,867	Reduced−1,047
US Foods HLDG CorpUSFD	COM	912008109	1.3	0.3%	13,000	New+13,000
Transdigm Group IncTDG	COM	893641100	1.3	0.3%	985	Reduced−160
Lumentum Holdings IncLITE	COM	55024U109	1.3	0.3%	1,517	Reduced−1,600
Firstenergy CorpFE	COM	337932107	1.2	0.3%	26,100	New+26,100
Mastercard IncorporatedMA	CL A	57636Q104	1.2	0.3%	2,384	Reduced−540
Entergy Corp NewETR	COM	29364G103	1.2	0.3%	10,628	Reduced−2,900
Krystal Biotech IncKRYS	COM	501147102	1.2	0.3%	3,260	Added+1,436
Moodys CorpMCO	COM	615369105	1.2	0.3%	2,670	New+2,670
Applied Matls IncAMAT	COM	038222105	1.2	0.3%	1,640	New+1,640
Xcel Energy IncXEL	COM	98389B100	1.2	0.3%	14,758	Added+2,200
Nextera Energy IncNEE	COM	65339F101	1.2	0.3%	13,338	Added+2,253
United Therapeutics Corp DelUTHR	COM	91307C102	1.1	0.3%	2,095	Added+581
Golar LNG Ltd	SHS	G9456A100	1.1	0.3%	22,100	New+22,100
Doordash IncDASH	CL A	25809K105	1.1	0.2%	5,810	Reduced−900
Icici Bank LimitedIBN	ADR	45104G104	1.0	0.2%	35,884	Added+8,000
Disc Medicine IncIRON	COM	254604101	1.0	0.2%	14,219	New+14,219
Amphenol CorpAPH	CL A	032095101	1.0	0.2%	5,781	Reduced−4,000
Unity Software IncU	COM	91332U101	1.0	0.2%	35,163	Reduced−27,600
Ferguson Enterprises IncFERG	COMMON STOCK NEW	31488V107	1.0	0.2%	4,173	Reduced−500
Trevi Therapeutics IncTRVI	COM	89532M101	1.0	0.2%	53,033	Reduced−492
Stmicroelectronics N VSTM	NY REGISTRY	861012102	1.0	0.2%	13,200	New+13,200
Septerna IncSEPN	COM	81734D104	1.0	0.2%	29,337	New+29,337
Full Truck Alliance Co LtdYMM	SPONSORED ADS	35969L108	1.0	0.2%	120,847	Added+43,656
Bridgebio Pharma IncBBIO	COM	10806X102	1.0	0.2%	13,156	Reduced−36,404
ARM Holdings plcARM	SPONSORED ADS	042068205	1.0	0.2%	2,700	New+2,700
Tapestry IncTPR	COM	876030107	1.0	0.2%	6,500	New+6,500
New Oriental Ed & TechnologyEDU	SPON ADR	647581206	0.9	0.2%	20,537	Added+8,220
Silicon Motion Technology CoSIMO	SPONSORED ADR	82706C108	0.9	0.2%	2,800	New+2,800
API Group CorpAPG	COM STK	00187Y100	0.9	0.2%	21,958	Reduced−4,700
Urogen Pharma Ltd	COM	M96088105	0.9	0.2%	24,968	Reduced−1,542
Microsoft CorpMSFT	COM	594918104	0.9	0.2%	2,413	Reduced−4,044
Zymeworks IncZYME	COM	98985Y108	0.9	0.2%	34,013	Reduced−72
Advanced Energy IndsAEIS	COM	007973100	0.8	0.2%	2,240	New+2,240
Kaspi KZ JSCKSPI	SPONSORED ADS	48581R205	0.8	0.2%	9,400	New+9,400
HDFC Bank LtdHDB	SPONSORED ADS	40415F101	0.8	0.2%	30,927	Added+4,800
Vistra CorpVST	COM	92840M102	0.8	0.2%	4,900	New+4,900
Janux Therapeutics IncJANX	COM	47103J105	0.7	0.2%	48,376	Reduced−1,007
Newamsterdam Pharma Company	ORDINARY SHARES	N62509109	0.7	0.2%	20,905	Added+838
Meta Platforms IncMETA	CL A	30303M102	0.7	0.1%	1,162	Reduced−580
MBX Biosciences IncMBX	COM	55287L101	0.6	0.1%	11,634	Added+162
NU Holdings Ltd	ORD SHS CL A	G6683N103	0.6	0.1%	47,970	Reduced−1,600
Cytomx Therapeutics Inc.CTMX	COM	23284F105	0.6	0.1%	169,831	Reduced−118,226
Mercadolibre IncMELI	COM	58733R102	0.6	0.1%	375	Reduced−60
Constellation Energy CorpCEG	COM	21037T109	0.6	0.1%	2,490	Reduced−3,262
Nektar TherapeuticsNKTR	COM NEW	640268306	0.6	0.1%	8,708	Reduced−5,847
Akamai Technologies IncAKAM	COM	00971T101	0.6	0.1%	4,900	New+4,900
Xencor IncXNCR	COM	98401F105	0.4	<0.1%	26,822	Reduced−26,223
Kymera Therapeutics IncKYMR	COM	501575104	0.4	<0.1%	3,731	Reduced−54
PDD Holdings IncPDD	SPONSORED ADS	722304102	0.4	<0.1%	5,500	Reduced−1,400
Jd.Com IncJD	SPON ADS CL A	47215P106	0.4	<0.1%	14,163	Added+700
Banco Bradesco S aBBD	SP ADR PFD NEW	059460303	0.4	<0.1%	103,132	Reduced−105,132

Sold out: 38 positions

Held at the end of the quarter before and not reported this quarter.

HighVista Strategies LLC, positions sold out
Issuer	Class	CUSIP	Weight	Change on the quarter before
3M CoMMM	COM	88579Y101	0.0%	Sold out−6,150
Amrize Ltd	SHS	H2927K103	0.0%	Sold out−17,068
Apogee Therapeutics Inc	COM	03770N101	0.0%	Sold out−35,761
Argan IncAGX	COM	04010E109	0.0%	Sold out−1,896
Ascendis Pharma A/S	SPONSORED ADR	04351P101	0.0%	Sold out−5,781
Avantor IncAVTR	COM	05352A100	0.0%	Sold out−186,500
Booking Holdings IncBKNG	COM	09857L108	0.0%	Sold out−283
Bridgebio Oncology TherapeutBBOT	COM NEW	107924102	0.0%	Sold out−78,187
Centessa Pharmaceuticals plc	SPONSORED ADS	152309100	0.0%	Sold out−5,964
Clean Harbors IncCLH	COM	184496107	0.0%	Sold out−5,543
Cleveland-Cliffs Inc NewCLF	COM	185899101	0.0%	Sold out−102,474
Corporacion Amer Arpts S a	COM	L1995B107	0.0%	Sold out−29,745
Coupang IncCPNG	CL A	22266T109	0.0%	Sold out−46,036
EQT CorpEQT	COM	26884L109	0.0%	Sold out−18,290
Everpure IncP	CL A	74624M102	0.0%	Sold out−14,009
GE Vernova IncGEV	COM	36828A101	0.0%	Sold out−1,218
IntuitINTU	COM	461202103	0.0%	Sold out−3,003
Jazz Pharmaceuticals plc	SHS USD	G50871105	0.0%	Sold out−10,838
Kanzhun LimitedBZ	SPONSORED ADS	48553T106	0.0%	Sold out−21,298
Kilroy Realty CorpKRC	COM	49427F108	0.0%	Sold out−41,997
NCR Atleos CorporationNATL	COM SHS	63001N106	0.0%	Sold out−40,100
Nokia CorpNOK	SPONSORED ADR	654902204	0.0%	Sold out−70,824
Nuvalent Inc	COM	670703107	0.0%	Sold out−56,602
Palvella Therapeutics Inc NePVLA	COM	697947109	0.0%	Sold out−5,903
Pennymac Finl SVCS Inc NewPFSI	COM	70932M107	0.0%	Sold out−7,306
Petroleo Brasileiro S aPBR	SP ADR NON VTG	71654V101	0.0%	Sold out−59,400
PTC IncPTC	COM	69370C100	0.0%	Sold out−7,474
Reddit IncRDDT	CL A	75734B100	0.0%	Sold out−6,900
RLX Technology IncRLX	SPONSORED ADS	74969N103	0.0%	Sold out−311,700
RXO IncRXO	COMMON STOCK	74982T103	0.0%	Sold out−43,038
Salesforce IncCRM	COM	79466L302	0.0%	Sold out−8,313
Sea LtdSE	SPONSORD ADS	81141R100	0.0%	Sold out−7,450
Soleno Therapeutics Inc	COM	834203309	0.0%	Sold out−165,227
Terns Pharmaceuticals Inc	COM	880881107	0.0%	Sold out−114,307
Trip Com Group LtdTCOM	ADS	89677Q107	0.0%	Sold out−5,484
Union Pac CorpUNP	COM	907818108	0.0%	Sold out−3,658
Workday IncWDAY	CL A	98138H101	0.0%	Sold out−8,286
Xoma Royalty Corporation	COM NEW	98419J206	0.0%	Sold out−46,814

Source: SEC EDGAR, Form 13F-HR, accession 0001172661-26-003470 (on sec.gov). Last ingested by Listed: Oct 22, 2026, 05:26 ET. Listed shows no prices and gives no investment advice.