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Rock Springs Capital Management LP

An institutional investment manager in Baltimore, MD. Its Form 13F for the quarter ended Jun 30, 2026, filed Aug 14, 2026. SEC CIK 1595725.

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Holdings: 104 positions

The filing on sec.gov

As filed, largest first. Reported value is what the manager stated for each position at the quarter end, in US dollars; it is filing data, not a price. Weight is the position's share of the total reported value. Changes compare with the 13F for the quarter ended 2026-03-31.

IssuerClassCUSIPReported value$mWeightSharesPut or callChange on the quarter before
Revolution Medicines IncRVMDCOM76155X10020710.1%1,105,210Reduced−104,255
Travere Therapeutics IncTVTXCOM89422G1071246.0%2,179,069Added+701,115
ELI Lilly & CoLLYCOM5324571081185.8%98,700Unchanged
Madrigal Pharmaceuticals IncMDGLCOM55886810594.04.6%174,999Added+4,000
Mirum Pharmaceuticals IncMIRMCOM60474910193.44.6%798,145Reduced−13,149
Rhythm Pharmaceuticals IncRYTMCOM76243J10576.93.8%692,598Added+2,850
Kymera Therapeutics IncKYMRCOM50157510452.02.5%453,156Reduced−43,715
Argenx SEARGXSPONSORED ADR04016X10148.92.4%52,750Reduced−45,750
Ascendis Pharma A/SORD SHSK0858810345.02.2%168,750New+168,750
Xenon Pharmaceuticals IncXENECOM98420N10541.32.0%683,907Reduced−79,113
Scholar Rock HLDG CorpSRRKCOM80706P10339.31.9%715,452Reduced−24,364
Insmed IncINSMCOM PAR $.0145766930738.61.9%362,150Added+47,850
Penumbra IncPENCOM70975L10736.51.8%115,750Reduced−4,750
Structure Therapeutics IncGPCRSPONSORED ADS86366E10634.41.7%640,317Added+100
Ultragenyx Pharmaceutical inRARECOM90400D10832.31.6%967,855Reduced−250,918
Irhythm Holdings IncIRTCCOM45005610632.11.6%269,650Added+7,900
Intuitive Surgical IncISRGCOM NEW46120E60230.41.5%76,460Reduced−5,540
Agilon Health IncAGLCOM NEW00857U20628.11.4%262,600Added+2,600
Unitedhealth Group IncUNHCOM91324P10226.51.3%63,750Added+10,750
Celldex Therapeutics Inc NewCLDXCOM NEW15117B20226.01.3%699,146Added+48,876
Erasca IncERASCOM29479A10825.71.3%1,402,150Added+298,681
Neurocrine Biosciences IncNBIXCOM64125C10924.41.2%144,750Reduced−5,700
Enliven Therapeutics IncELVNCOM29337E10223.61.2%464,625Reduced−361,875
Tenet Healthcare CorpTHCCOM NEW88033G40723.41.1%125,000Unchanged
Dexcom IncDXCMCOM25213110723.11.1%343,000Reduced−12,600
Aclaris Therapeutics IncACRSCOM00461U10522.91.1%4,330,532Reduced−142,118
Minimed Group IncMMEDCOM60365F10922.71.1%1,520,000Added+465,000
Boston Scientific CorpBSXCOM10113710722.61.1%528,500Added+13,200
Pharvaris N VCOMN6960510822.41.1%648,333Added+2,800
Avalyn Pharmaceuticals IncAVLNCOM SHS05348Y10521.81.1%662,918New+662,918
Hemab Therapeutics Holdings IncCOAGCOM SHS42349410321.11.0%575,432New+575,432
Dyne Therapeutics IncDYNCOM26818M10820.91.0%942,154Reduced−30,044
Alnylam Pharmaceuticals IncALNYCOM02043Q10720.11.0%66,750Reduced−7,250
Cogent Biosciences IncCOGTCOM19240Q20120.01.0%515,917Reduced−108,238
Agios Pharmaceuticals IncAGIOCOM00847X10419.81.0%532,563Reduced−266,600
Newamsterdam Pharma CompanyORDINARY SHARESN6250910919.71.0%582,744Reduced−6,050
Vera Therapeutics IncVERACL A92337R10118.30.9%427,584Reduced−76,001
Tarsus Pharmaceuticals IncTARSCOM87650L10317.40.9%277,087Added+51,908
Heartflow IncHTFLCOM42238D10716.80.8%573,500Added+1,000
MBX Biosciences IncMBXCOM55287L10116.50.8%298,218Added+10,251
Cytokinetics IncCYTKCOM NEW23282W60516.00.8%187,980Added+142,616
Bicara Therapeutics IncBCAXCOM05547710315.90.8%535,286Added+46,191
Parabilis Medicines IncPBLSCOM69895510115.80.8%578,028New+578,028
ZAI Lab LtdZLABADR98887Q10415.50.8%814,707Unchanged
Danaher Corp DelDHRCOM23585110214.50.7%76,300Added+14,800
Tango Therapeutics IncTNGXCOM87583X10914.30.7%456,551Added+69,636
Evolent Health IncEVHCL A30050B10113.60.7%2,500,000Reduced−175,000
PTC Therapeutics IncPTCTCOM69366J20013.20.6%162,298Added+500
Mineralys Therapeutics IncMLYSCOM60317010113.10.6%484,951Added+45,200
Zenas Biopharma IncZBIOCOM98937L10512.70.6%502,077Unchanged
Ardelyx IncARDXCOM03969710711.40.6%2,241,769Reduced−57,704
Inspire Med Sys IncINSPCOM45773010910.90.5%244,000Added+112,200
Bridgebio Pharma IncBBIOCOM10806X10210.80.5%144,750Added+16,500
Alkermes plcSHSG0176710510.50.5%199,811Added+15,825
Summit Therapeutics IncSMMTCOM86627T10810.40.5%715,000Added+5,000
Azenta IncAZTACOM11434010210.30.5%403,000Reduced−166,100
Indivior Pharmaceuticals IncINDVCOM45579U10910.10.5%245,500Added+45,500
Stryker CorporationSYKCOM8636671019.10.4%29,000Added+14,200
Amylyx Pharmaceuticals IncAMLXCOM03237H1019.00.4%499,764Unchanged
Caris Life Sciences IncCAICOM1421521078.70.4%487,500Reduced−75,500
Omada Health IncOMDACOM68170A1088.20.4%373,000Reduced−168,000
Compass Therapeutics IncCMPXCOM20454B1047.70.4%3,524,929Added+219,621
Immunome IncIMNMCOM45257U1087.40.4%347,666Unchanged
Edap TMS S aFOCLSPONSORED ADR2683111077.20.4%1,386,000Added+8,000
Phreesia IncPHRCOM71944F1067.20.4%696,900Added+96,500
Omeros CorpOMERCOM6821431026.80.3%718,499New+718,499
Definium Therapeutics IncDFTXCOM SHS24477V1056.70.3%143,187New+143,187
Corcept Therapeutics IncCORTCOM2183521026.30.3%72,000Added+21,750
Janux Therapeutics IncJANXCOM47103J1055.60.3%367,009Unchanged
Mobia Med IncMOBICOMMON STOCK60705V1035.60.3%418,200New+418,200
Arcus Biosciences IncRCUSCOM03969F1095.50.3%180,000Unchanged
Thermo Fisher Scientific IncTMOCOM8835561025.00.2%10,000Unchanged
Trevi Therapeutics IncTRVICOM89532M1014.80.2%260,000New+260,000
Sionna Therapeutics IncSIONCOM8294011084.40.2%99,429Unchanged
CVS Health CorpCVSCOM1266501004.10.2%40,000Unchanged
Eyepoint IncEYPTCOM NEW30233G2093.80.2%268,519Added+9,780
Ocular Therapeutix IncOCULCOM67576A1003.80.2%383,716Unchanged
Spyre Therapeutics IncSYRECOM NEW00773J2023.80.2%42,254New+42,254
Talphera IncTLPHCOM NEW00444T2093.70.2%3,589,186Unchanged
Roivant Sciences LtdSHSG762791013.60.2%101,000Added+4,000
Vaxcyte IncPCVXCOM92243G1083.50.2%60,250Unchanged
Neurogene IncNGNECOM64135M1053.40.2%106,750Added+2,411
Century Therapeutics IncIPSCCOM15673T1003.20.2%1,304,347Unchanged
Alphatec Holdings IncATECCOM NEW02081G2013.10.2%360,000Added+10,000
Novo-Nordisk a SNVOADR6701002053.00.1%63,500Reduced−26,500
Olema Pharmaceuticals IncOLMACOM68062P1062.90.1%235,178Added+64,800
Nervgen Pharma CorpNGENCOM64082X2032.50.1%1,208,231New+1,208,231
Medtronic plcSHSG5960L1032.40.1%30,900New+30,900
Teva Pharmaceutical Inds LtdSPONSORED ADS8816242092.0<0.1%59,000Added+13,500
Dianthus Therapeutics IncDNTHCOM2528281082.0<0.1%20,326Reduced−6,431
Sagimet Biosciences IncSGMTCOM SER A7867001041.9<0.1%250,000New+250,000
Capricor Therapeutics IncCAPRCOM NEW14070B3091.8<0.1%74,448New+74,448
Lenz Therapeutics IncLENZCOM52635N1031.5<0.1%257,460Unchanged
Altimmune IncALTCOM NEW02155H2001.4<0.1%471,465New+471,465
Kailera Therapeutics IncKLRACOMMON STOCK4829311021.4<0.1%65,000New+65,000
Surgery Partners IncSGRYCOM86881A1001.4<0.1%84,000Reduced−124,000
Axsome Therapeutics Inc.AXSMCOM05464T1041.3<0.1%5,500New+5,500
Oruka Therapeutics IncORKACOM6876041081.1<0.1%12,051Added+7,928
Viking Therapeutics IncVKTXCOM92686J1061.0<0.1%25,500Reduced−70,500
Legend Biotech CorpLEGNSPONSORED ADS52490G1021.0<0.1%33,500Reduced−7,000
Glaukos CorpGKOSCOM3773221020.7<0.1%4,750New+4,750
Jasper Therapeutics IncJSPRCOM NEW4718712020.5<0.1%1,100,726Unchanged
Biocryst Pharmaceuticals IncBCRXCOM09058V1030.2<0.1%22,124Added+9,524
Moonlake ImmunotherapeuticsMLTXCLASS A ORD61559X1040.2<0.1%10,696Reduced−51,004

Sold out: 13 positions

Held at the end of the quarter before and not reported this quarter.

IssuerClassCUSIPReported value$WeightSharesPut or callChange on the quarter before
Acadia Healthcare Company inACHCCOM00404A1090.00.0%0Sold out−75,500
Amicus TherapeuticCOM03152W1090.00.0%0Sold out−21,062
Apellis Pharmaceuticals IncCOM03753U1060.00.0%0Sold out−162,750
Arcellx IncCOMMON STOCK03940C1000.00.0%0Sold out−169,859
Ascendis Pharma A/SSPONSORED ADR04351P1010.00.0%0Sold out−194,000
Centessa Pharmaceuticals plcSPONSORED ADS1523091000.00.0%0Sold out−351,828
Edwards Lifesciences CorpEWCOM28176E1080.00.0%0Sold out−28,900
Gossamer Bio IncCOM38341P1020.00.0%0Sold out−1,609,492
Jazz Pharmaceuticals plcSHS USDG508711050.00.0%0Sold out−5,750
Regeneron PharmaceuticalsREGNCOM75886F1070.00.0%0Sold out−10,100
Soleno Therapeutics IncCOM8342033090.00.0%0Sold out−257,253
SPDR Series TrustSTATE STREET SPD78464A8700.00.0%0Sold out−30,000
Terns Pharmaceuticals IncCOM8808811070.00.0%0Sold out−113,748

Source: SEC EDGAR, Form 13F-HR, accession 0001172661-26-003527 (on sec.gov). Last ingested by Listed: Oct 22, 2026, 05:26 ET. Listed shows no prices and gives no investment advice.