Paradigm Biocapital Advisors LP
An institutional investment manager in NEW YORK, NY. Its Form 13F for the quarter ended Jun 30, 2026, filed Aug 14, 2026. SEC CIK 1855655.
- Reported value$5.34bn
- Positions28
Holdings: 28 positions
The filing on sec.govAs filed, largest first. Reported value is what the manager stated for each position at the quarter end, in US dollars; it is filing data, not a price. Weight is the position's share of the total reported value. Changes compare with the 13F for the quarter ended 2026-03-31.
| Issuer | Class | CUSIP | Reported value$m | Weight | Shares | Put or call | Change on the quarter before |
|---|---|---|---|---|---|---|---|
| Revolution Medicines IncRVMD | COM | 76155X100 | 1,191 | 22.3% | 6,361,323 | Reduced−294,380 | |
| Nuvalent Inc | COM | 670703107 | 732 | 13.7% | 5,924,433 | Added+600,000 | |
| Edgewise Therapeutics IncEWTX | COM | 28036F105 | 415 | 7.8% | 10,215,455 | Added+2,850,417 | |
| Genmab A/SGMAB | SPONSORED ADS | 372303206 | 361 | 6.8% | 13,133,131 | Added+5,165,295 | |
| Spyre Therapeutics IncSYRE | COM NEW | 00773J202 | 341 | 6.4% | 3,840,778 | Added+1,883,512 | |
| Apogee Therapeutics Inc | COM | 03770N101 | 209 | 3.9% | 1,576,385 | Added+228,142 | |
| Oruka Therapeutics IncORKA | COM | 687604108 | 204 | 3.8% | 2,144,526 | Reduced−175,790 | |
| Tango Therapeutics IncTNGX | COM | 87583X109 | 199 | 3.7% | 6,357,523 | Added+2,347,844 | |
| Belite Bio IncBLTE | SPONSORED ADS | 07782B104 | 190 | 3.6% | 1,232,877 | Added+118,093 | |
| Erasca IncERAS | COM | 29479A108 | 175 | 3.3% | 9,550,000 | Reduced−842,702 | |
| Tarsus Pharmaceuticals IncTARS | COM | 87650L103 | 175 | 3.3% | 2,775,649 | Added+213,495 | |
| Alnylam Pharmaceuticals IncALNY | COM | 02043Q107 | 144 | 2.7% | 480,000 | New+480,000 | |
| Insmed IncINSM | COM PAR $.01 | 457669307 | 141 | 2.6% | 1,325,977 | Added+71,489 | |
| MBX Biosciences IncMBX | COM | 55287L101 | 138 | 2.6% | 2,508,015 | New+2,508,015 | |
| Vaxcyte IncPCVX | COM | 92243G108 | 124 | 2.3% | 2,127,852 | Reduced−2,665,168 | |
| Viridian Therapeutics IncVRDN | COM | 92790C104 | 124 | 2.3% | 6,723,788 | Added+3,574,895 | |
| Olema Pharmaceuticals IncOLMA | COM | 68062P106 | 108 | 2.0% | 8,670,576 | Added+650,000 | |
| Jade Biosciences IncJBIO | COM NEW | 008064206 | 63.5 | 1.2% | 2,857,405 | New+2,857,405 | |
| Tyra Biosciences IncTYRA | COM | 90240B106 | 58.4 | 1.1% | 1,828,607 | Reduced−226,384 | |
| Assembly Biosciences IncASMB | COM NEW | 045396207 | 42.7 | 0.8% | 1,553,748 | Added+888,497 | |
| Eyepoint IncEYPT | COM NEW | 30233G209 | 41.3 | 0.8% | 2,890,397 | Reduced−252,040 | |
| Achieve Life Science IncACHV | COM | 004468500 | 32.3 | 0.6% | 4,951,856 | New+4,951,856 | |
| VOR Biopharma IncVOR | COM NEW | 929033207 | 32.2 | 0.6% | 1,750,000 | Unchanged | |
| Maplight Therapeutics IncMPLT | COM | 56565P103 | 24.6 | 0.5% | 685,852 | New+685,852 | |
| Kardigan IncKARD | COM | 485925101 | 21.5 | 0.4% | 900,000 | New+900,000 | |
| Lexeo Therapeutics IncLXEO | COM | 52886X107 | 19.4 | 0.4% | 4,175,382 | Reduced−2,008,752 | |
| Editas Medicine IncEDIT | COM | 28106W103 | 18.1 | 0.3% | 5,586,625 | New+5,586,625 | |
| Inventiva SAIVA | ADS | 46124U107 | 15.1 | 0.3% | 4,000,000 | Unchanged |
Sold out: 14 positions
Held at the end of the quarter before and not reported this quarter.
| Issuer | Class | CUSIP | Reported value$ | Weight | Shares | Put or call | Change on the quarter before |
|---|---|---|---|---|---|---|---|
| Abivax SAABVX | SPONSORED ADS | 00370M103 | 0.0 | 0.0% | 0 | Sold out−772,473 | |
| Arcellx Inc | COMMON STOCK | 03940C100 | 0.0 | 0.0% | 0 | Sold out−5,774,016 | |
| Bridgebio Oncology TherapeutBBOT | COM NEW | 107924102 | 0.0 | 0.0% | 0 | Sold out−868,213 | |
| Centessa Pharmaceuticals plc | SPONSORED ADS | 152309100 | 0.0 | 0.0% | 0 | Sold out−3,574,048 | |
| Cytokinetics IncCYTK | COM NEW | 23282W605 | 0.0 | 0.0% | 0 | Sold out−1,480,857 | |
| Kalaris Therapeutics IncKLRS | COM | 482929106 | 0.0 | 0.0% | 0 | Sold out−700,000 | |
| Maze Therapeutics IncMAZE | COM | 578784100 | 0.0 | 0.0% | 0 | Sold out−2,744,399 | |
| Mirum Pharmaceuticals IncMIRM | COM | 604749101 | 0.0 | 0.0% | 0 | Sold out−625,000 | |
| Oric Pharmaceuticals IncORIC | COM | 68622P109 | 0.0 | 0.0% | 0 | Sold out−1,701,217 | |
| Scholar Rock HLDG CorpSRRK | COM | 80706P103 | 0.0 | 0.0% | 0 | Sold out−1,226,080 | |
| Structure Therapeutics IncGPCR | SPONSORED ADS | 86366E106 | 0.0 | 0.0% | 0 | Sold out−545,287 | |
| Terns Pharmaceuticals Inc | COM | 880881107 | 0.0 | 0.0% | 0 | Sold out−2,216,499 | |
| Urogen Pharma Ltd | COM | M96088105 | 0.0 | 0.0% | 0 | Sold out−1,703,949 | |
| Veradermics IncMANE | COMMON STOCK | 922967104 | 0.0 | 0.0% | 0 | Sold out−525,000 |
Source: SEC EDGAR, Form 13F-HR, accession 0001855655-26-000014 (on sec.gov). Last ingested by Listed: Oct 22, 2026, 05:26 ET. Listed shows no prices and gives no investment advice.